Application of synthetic alkyl glycoside vesicles as drug carriers. I. Preparation and physical properties.

Kojima, Hiroshi; Niimura, Hitoshi; Fujisaki, Yuichi; Yamada, Sunju; Kato, Yuriko

doi:10.1248/cpb.33.753

Cited by 90 publications

(34 citation statements)

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“…Multilamellar liposomes were prepared as described previously (Kiwada et al, 1985). In brief, 58.72 mg of phosphatidylcholine (Nihon Seika, Hyogo, Japan), 8.75 mg of dehexadecyl phosphate (Nacalai Tesque, Kyouto, Japan), and 24.75 mg of cholesterol (Wako Pure Chemicals, Tokyo, Japan) were dissolved in chloroform in a round-bottom flask and dried under reduced pressure.…”

Section: Methodsmentioning

confidence: 99%

Glycyrrhizin Prevents Liver Injury by Inhibition of High-Mobility Group Box 1 Production by Kupffer Cells after Ischemia-Reperfusion in Rats

Ogiku

Kono²,

Hara³

et al. 2011

J Pharmacol Exp Ther

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High-mobility group box 1 (HMGB1) acts as an early mediator of inflammation and organ damage in hepatic ischemia-reperfusion (I/R) injury. Glycyrrhizin is a natural anti-inflammatory and antiviral triterpene in clinical use. The purpose of this study was to investigate the effect of glycyrrhizin on liver injury caused by I/R and production of HMGB1 by Kupffer cells in rats. In the first test period, rats were given saline or glycyrrhizin 20 min before segmental hepatic warm I/R. Serum alanine aminotransferase and HMGB1 levels and hepatic histopathological findings were evaluated after I/R. Furthermore, expression of HMGB1 in the liver was assessed by immunohistochemical staining after I/R. Kupffer cells were isolated by collagenase digestion and differential centrifugation, and production of HMGB1 was assessed. In another set of experiments, the effect of inhibition of Kupffer cells by injection of liposome-entrapped dichloromethylene diphosphonate (lipo-MDP) on liver injury and expression of HMGB1 were investigated after I/R. Liver injury was prevented in the glycyrrhizin group compared with the control group. Furthermore, serum HMGB1 levels were also significantly blunted in the glycyrrhizin group compared with the control group. Cells expressing HMGB1 were detected in the hepatic sinusoid by immunohistochemistry and recognized morphologically as Kupffer cells. Furthermore, the expression of HMGB1 was reduced in the glycyrrhizin group compared with the control group. Production of HMGB1 was reduced in Kupffer cells isolated from the glycyrrhizin group compared with the control group. It is noteworthy that treatment with lipo-MDP significantly blunted serum HMGB1 levels and prevented liver injury after I/R. These results suggest that glycyrrhizin has the therapeutic potential to prevent warm I/R-induced injury during hepato-biliary surgery.

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Section: Methodsmentioning

confidence: 99%

Glycyrrhizin Prevents Liver Injury by Inhibition of High-Mobility Group Box 1 Production by Kupffer Cells after Ischemia-Reperfusion in Rats

Ogiku

Kono²,

Hara³

et al. 2011

J Pharmacol Exp Ther

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“…The organic solvent is then slowly evaporated to leave niosomes dispersed in the aqueous phase. In some cases, a gel results which must be further hydrated to yield niosomes [reverse phase evaporation (REV)] (Szoka & Papahadjopoulos, 1978;Kiwada et al, 1985). The vesicles generated by the REV method are unilamellar or oligolamellar and are relatively more uniform in size compared with the TFH method (Szoka & Papahadjopoulos, 1978;Abdelkader et al, 2011).…”

Section: Vesicle Preparationmentioning

confidence: 99%

Recent advances in non-ionic surfactant vesicles (niosomes): self-assembly, fabrication, characterization, drug delivery applications and limitations

2013

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Non-ionic surfactant vesicles, simply known as niosomes are synthetic vesicles with potential technological applications. Niosomes have the same potential advantages of phospholipid vesicles (liposomes) of being able to accommodate both water soluble and lipid soluble drug molecules control their release and as such serve as versatile drug delivery devices of numerous applications. Additionally, niosomes can be considered as more economically, chemically, and occasionally physically stable alternatives to liposomes. Niosomes can be fabricated using simple methods of preparations and from widely used surfactants in pharmaceutical technology. Many reports have discussed niosomes in terms of physicochemical properties and their applications as drug delivery systems. In this report, a brief and simplified summary of different theories of self-assembly will be given. Furthermore manufacturing methods, physical characterization techniques, bilayer membrane additives, unconventional niosomes (discomes, proniosomes, elastic and polyhedral niosomes), their recent applications as drug delivery systems, limitations and directions for future research will be discussed.

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“…Other than alkyl glycerol, alkyl glycosides and alkyl ethers bearing polyhydroxyl head groups are also used in formulation of niosomes. 4,6,7) 2.1.2. Alkyl Esters Sorbitan esters are most preferred surfactant used for the preparation of niosomes amongst this category of surfactants.…”

Section: Components Of Niosomesmentioning

confidence: 99%

“…6,24,37) Volume of hydration medium and time of hydration of niosomes are also critical factors which affects the niosomal assembly along with the above mentioned factors. Improper selection of these factors may result in formation of fragile niosomes or creation of drug leakage problems.…”

Section: Resistance To Osmotic Stressmentioning

confidence: 99%

Niosomes: A Controlled and Novel Drug Delivery System

Rajera

Nagpal

Singh

et al. 2011

Biological & Pharmaceutical Bulletin

283

162

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During the past decade formulation of vesicles as a tool to improve drug delivery, has created a lot of interest amongst the scientist working in the area of drug delivery systems. Vesicular system such as liposomes, niosomes, transferosomes, pharmacosomes and ethosomes provide an alternative to improve the drug delivery. Niosomes play an important role owing to their nonionic properties, in such drug delivery system. Design and development of novel drug delivery system (NDDS) has two prerequisites. First, it should deliver the drug in accordance with a predetermined rate and second it should release therapeutically effective amount of drug at the site of action. Conventional dosage forms are unable to meet these requisites. Niosomes are essentially non-ionic surfactant based multilamellar or unilamellar vesicles in which an aqueous solution of solute is entirely enclosed by a membrane resulting from the organization of surfactant macromolecules as bilayer. Niosomes are formed on hydration of non-ionic surfactant film which eventually hydrates imbibing or encapsulating the hydrating aqueous solution. The main aim of development of niosomes is to control the release of drug in a sustained way, modification of distribution profile of drug and for targeting the drug to the specific body site. This paper deals with composition, characterization/evaluation, merits, demerits and applications of niosomes.

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Application of synthetic alkyl glycoside vesicles as drug carriers. I. Preparation and physical properties.

Cited by 90 publications

References 0 publications

Glycyrrhizin Prevents Liver Injury by Inhibition of High-Mobility Group Box 1 Production by Kupffer Cells after Ischemia-Reperfusion in Rats

Glycyrrhizin Prevents Liver Injury by Inhibition of High-Mobility Group Box 1 Production by Kupffer Cells after Ischemia-Reperfusion in Rats

Recent advances in non-ionic surfactant vesicles (niosomes): self-assembly, fabrication, characterization, drug delivery applications and limitations

Niosomes: A Controlled and Novel Drug Delivery System

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