Application of⁶²Cu-Diacetyl-Bis (N⁴-Methylthiosemicarbazone) PET Imaging to Predict Highly Malignant Tumor Grades and Hypoxia-Inducible Factor-1α Expression in Patients with Glioma

Positron emission tomography to assess hypoxia and perfusion in lung cancer

“…The short-lived radionuclides can be used for sequential measurements, whereas radionuclides with longer half lives do Table 2 for full names. Lewis et al [133] , Yuan et al [134] , Kersemans et al [135] , Matsumoto et al [136] Ballegeer et al [137] , Bowen et al [138] , Lewis et al [133] , Myerson et al [139] , O'Donoghue et al [72] Ballegeer et al [137] , Hansen et al [140] , Matsumoto et al [136] , McCall et al [66] , O'Donoghue et al [72] , Oh et al [74] , Yuan et al [134] Grigsby et al [141] , Tateishi et al [142] , Valtorta et al [143] , Weeks et al [144] Dence et al [145] , Kersemans et al [135] , Lewis et al [146] , Matsumoto et al [136] , O'Donoghue et al [72] Dehdashti et al [86] , Lohith et al [67] , Wong et al [80] , Zhang et al [81] Chao et al [147] , Dehdashti et al [148] , Dehdashti et al [149] , Dietz et al [150] , Grassi et al [151] , Grigsby et al [141] , Kositwattanarerk et al [152] , Laforest et al [153] , Lewis et al [154] , Minagawa et al [155] , Nyflot et al [156] [ Mahy et al [158] , Mahy et al …”

62Cu-Diacetyl-Bis (N4-Methylthiosemicarbazone) PET in Human Gliomas: Comparative Study with [18F]Fluorodeoxyglucose and L-Methyl-[11C]Methionine PET

“…9 In our current study, MET-PET revealed a significant difference between GBM and non-GBM despite the high frequency of oligodendroglial tumors. However, these oligodendroglial tumors are reported to show relatively high uptake of MET irrespective of their grade on MET-PET, 3,4 19 Our preliminary clinical study also showed that 62 Cu-ATSM uptake values correlated highly with hypoxia-inducible factor-1␣ expression, which is a biomarker of tissue hypoxia, 14 and the optimal cutoff threshold to predict hypoxia-inducible factor-1␣ expression (T/B ratio, 1.8) was similar to that of our present study in the prediction of GBM (T/B ratio, 1.9). It has been well established that overexpression of hypoxia-inducible factor-1␣, a transcription factor that is part of the stress response mechanism, is initiated in the presence of low oxygen tensions and induces hypoxia-regulated molecules, such as vascular endothelial growth factor, glucose transporters, and carbonic anhydrase IX, 21 which correlate with treatment resistance and are highly expressed in GBM.…”

“…To evaluate volumetric analysis, we extracted the uptake regions of the 62 Cu-ATSM images on the basis of the optimal T/B ratio thresholds of Ն1.8, a cutoff value for predicting hypoxiainducible factor-1␣ expression in our previous study. 14 The uptake regions of the FDG and MET images were extracted on the basis of the T/B ratio thresholds of Ն1.5 and Ն1.3, respectively, in accordance with previous reports. 5,9 These uptake regions were rated as metabolically active volumes.…”

“…The uptake values of the 62 Cu-ATSM, FDG, and MET tracers were determined by assessment of the maximum standardized uptake value (SUV max ) values and T/B ratios. Dr. View version R 2.5 for LINUX (Infocom, Tokyo, Japan) software was used to merge the PET images with the MR images, 4,13,14 and each PET and MR image was volumetrically compared. To evaluate volumetric analysis, we extracted the uptake regions of the 62 Cu-ATSM images on the basis of the optimal T/B ratio thresholds of Ն1.8, a cutoff value for predicting hypoxiainducible factor-1␣ expression in our previous study.…”

Hypoxia Imaging with 18F-FMISO PET for Brain Tumors

“…Here, autoradiography showed a strong correlation between the Cu-ATSM and FMISO distributions [53]. Tateishi et al acquired Cu-ATSM PET for glioma patients and demonstrated a correlation between Cu-ATSM uptake and glioma grades [54]. Despite evidence, it is still not substantiated whether Cu-ATSM represents hypoxia.…”