Application of stimuli responsive polymers for sustainable ion exchange chromatography

Terefe, Netsanet Shiferaw; Glagovskaia, O.; Silva, Kirthi De; Stockmann, Regine

doi:10.1016/j.fbp.2014.02.003

Cited by 29 publications

(10 citation statements)

References 147 publications

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“…Currently the most prevalent use for smart polymers in biomedicine is specifically related to targeted drug delivery systems [86]- [88]. However, other biomedical applications such as gene and tissue engineering, chemotherapy, biochromatography, and biomembrane technology have also been reported [89]- [93]. The most relevant inconvenient with the use of smart polymers in biomedicine is related to the toxicity or incompatibility of artificial substances with the human body.…”

Section: Smart Polymersmentioning

confidence: 99%

Smart Polymers and Coatings Obtained by Ionizing Radiation: Synthesis and Biomedical Applications

Meléndez‐Ortiz¹,

Varca²,

Lugão³

et al. 2015

OJPChem

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Gamma radiation has been shown particularly useful for the functionalization of surfaces with stimuli-responsive polymers. This method involves the formation of active sites (free radicals) onto the polymeric backbone as a result of the exposition to high-energy radiation, in which a proper microenvironment for the reaction among monomer and/or polymer and the active sites takes place, thus leading to propagation which forms side chain grafts. The modification of polymers using high-energy irradiation may be performed by the following methods: direct or simultaneous, pre-irradiation oxidative and pre-irradiation. The most frequent ones correspond to the pre-irradiation oxidative method and the direct one. Radiation-grafting has many advantages over conventional methods considering that it does not require catalyst nor additives to initiate the reaction, and in general, no changes on the mechanical properties with respect to the pristine polymeric matrix are observed. This chapter focused on the synthesis of smart polymers and coatings obtained by the use of gamma radiation. In addition, diverse applications of these materials in the biomedical field are also reported.

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Section: Smart Polymersmentioning

confidence: 99%

Smart Polymers and Coatings Obtained by Ionizing Radiation: Synthesis and Biomedical Applications

Meléndez‐Ortiz¹,

Varca²,

Lugão³

et al. 2015

OJPChem

View full text Add to dashboard Cite

show abstract

“…Most of this has involved modification of small pored inorganic or hydrophobic (polystyrene based) chromatography supports for use in analytical separations of small biomolecules (especially steroids). In stark contrast, very little has been done on the modification of softer macroporous media for preparative separations of much larger macromolecules, such as proteins [22][23][24]. Maharjan et al [22] and subsequently we [23] grafted lightly cross-linked networks of poly(N-isopropylacrylamide-co-N-tertbutylacrylamide-co-acrylic acid) onto the surfaces of cross-linked agarose supports to produce thermoresponsive cation exchangers (hereafter abbreviated to thermoCEX).…”

Section: Introductionmentioning

confidence: 95%

“…A large body of work on endowing chromatographic packing materials with temperature switchable behavior, through their modification with e.g. pNIPAAm or pNIPAAm copolymers, has appeared since the 1990s [19][20][21][22][23][24]. Most of this has involved modification of small pored inorganic or hydrophobic (polystyrene based) chromatography supports for use in analytical separations of small biomolecules (especially steroids).…”

Section: Introductionmentioning

confidence: 99%

Integrated system for temperature-controlled fast protein liquid chromatography. II. Optimized adsorbents and ‘single column continuous operation’

Cao

Müller

Ketterer

et al. 2015

Journal of Chromatography A

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“…Smart polymers that are capable of conformational changes in their network structure and swelling properties in response to one or two external stimuli, have recently become interesting materials in many research areas such as drug delivery, optical and electrical devices, sensors, and separation science [1][2][3][4][5][6][7]. Among them, those containing metal nanoparticles have received particular attention since they not only simply combine the advantageous properties of both metal complexes and polymers, but also show new attractive properties that do not appear in either [8,9].…”

Section: Introductionmentioning

confidence: 99%

Laser-assisted triggered-drug release from silver nanoparticles-grafted dual-responsive polymer

Amoli‐Diva

Sadighi‐Bonabi

Pourghazi³

2017

Materials Science and Engineering: C

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Laser assisted drug release from a synthesized plain polymer composed of poly (butyl methacrylate-co-acrylamide-co-methacrylic acid) [P(BMA-co-AAm-co-MAA)] and a metallo-polymer composed of silver nanoparticles (Ag NPs) grafted plain polymer (the nanocomposite) were studied to investigate their capability to serve as drug carriers. Positive temperature dependent swelling changes were observed for both carriers and their thermal sensitivity and thermal and optical switching properties were investigated in two buffered solutions. An acidic solution with pH=1.2 to simulate stomach body condition and a neutral solution with pH=7.4 to simulate intestine condition. Reversible phase transition (collapsing/swelling) with fast response time in the order of few seconds were observed by applying heat or by applying light radiation at the surface plasmon resonance wavelength of the attached NPs. Finally, cumulative release (%) of ofloxacin antibiotic as a model drug was investigated for both thermal and optical switching conditions. Based on these results, pulsatile release was observed which have the "on" and "off" states at higher and lower temperatures with respect to their volume-phase transition temperatures respectively.

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Application of stimuli responsive polymers for sustainable ion exchange chromatography

Cited by 29 publications

References 147 publications

Smart Polymers and Coatings Obtained by Ionizing Radiation: Synthesis and Biomedical Applications

Smart Polymers and Coatings Obtained by Ionizing Radiation: Synthesis and Biomedical Applications

Integrated system for temperature-controlled fast protein liquid chromatography. II. Optimized adsorbents and ‘single column continuous operation’

Laser-assisted triggered-drug release from silver nanoparticles-grafted dual-responsive polymer

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