Application of Statistical Methods in Physiology

Dunn, Halbert L.

doi:10.1152/physrev.1929.9.2.275

Cited by 83 publications

(35 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Having calculated the correlations for the three interlocking relationships: oxygen consumption and body surface area, cardiac output and oxygen consumption, and cardiac output and surface area for the normal circulation group, it is possible to make use of the statistical device known as partial correlation (8). This permits holding one of the variables constant by mathematical means and studying the resulting effect on the relationship between the other two.…”

Section: Discussion Of Relationshipsmentioning

confidence: 99%

See 1 more Smart Citation

Studies of the Heart and Circulation in Disease; Estimations of Basal Cardiac Output, Metabolism, Heart Size, and Blood Pressure in 235 Subjects

Starr

Donal²,

Margolies³

et al. 1934

J. Clin. Invest.

View full text Add to dashboard Cite

In a previous communication the results of duplicate estimations of cardiac output on 50 persons, the majority hospital patients in the basal condition, have been ret)orted (1). The opportunity to extend this investigation rapidly was provided by the development, by Donal and Gamble, of a physical method for the estimation of ethyl iodide by means of its thermal conductivity in a katharometer (2). This improvement so increased the rapidity with which the cardiac output could be estimated, that about two hundred hospital cases, four hundred estimations of cardiac output, were added to the series with the expenditure of less time and effort than had been required to secure the results in the first fifty cases by the chemical technique. When the new series was combined with the old, over 200 cases were secured in which satisfactory estimations of basal cardiac output, metabolism, blood pressure, and pulse rate, had been made on resting patients 15 or more hours after the last meal; and in which orthodiagrams had been secured also. The analysis of these results forms the subject of this paper.As soon as results, secured by any cardiac output method, are examined a difficulty appears which can best be set forth by an example. The average cardiac output of 31 healthy persons is 2.9 liters per minute per 100 pounds, that of 8 cases of anemia 3.2 liters; should the difference be considered significant or not? An estimation of the validity of differences is based on knowledge of the relative accuracy of the methods involved. One may try to ascertain the accuracy of a cardiac output method, when applied to man, by the agreement of duplicate estimations, and by comparison of the results with those obtained by other methods, preferably based on different physiological principles. But it should be emphasized that cardiac output procedures have not attained the position of those methods the accuracy of which can be tested by estimation of known quantities. Therefore, we have fallen back on another way of approaching the problem and have estimated the significance of our differences by statistical procedures. 561

show abstract

Section: Discussion Of Relationshipsmentioning

confidence: 99%

“…The katharometer was tested 25 times, usually at intervals of 10 (8) proved most useful, and the methods there described have been followed.…”

mentioning

confidence: 99%

Studies of the Heart and Circulation in Disease; Estimations of Basal Cardiac Output, Metabolism, Heart Size, and Blood Pressure in 235 Subjects

Starr

Donal²,

Margolies³

et al. 1934

J. Clin. Invest.

View full text Add to dashboard Cite

show abstract

“…10 Dunn may have been the first person to publish the findings of a review of an explicit sample of journal publications. 5 His unfortunately brief summary of his observations about the 200 articles he examined was as follows:…”

Section: Evaluating the Quality Of Medical Researchmentioning

confidence: 99%

A history of the evolution of guidelines for reporting medical research: the long road to the EQUATOR Network

2016

View full text Add to dashboard Cite

“…The statistical analysis followed that described by Dunn (11). The standard error was obtained by the formula where a is the standard deviation and n, the number of observations.…”

Section: Calculationsmentioning

confidence: 99%

The Effect of Hyperthermia on the Distribution of Water and Electrolytes in Brain, Muscle and Liver 1

Yannet¹,

Darrow²

1938

J. Clin. Invest.

View full text Add to dashboard Cite

Application of Statistical Methods in Physiology

Cited by 83 publications

References 0 publications

Studies of the Heart and Circulation in Disease; Estimations of Basal Cardiac Output, Metabolism, Heart Size, and Blood Pressure in 235 Subjects

Studies of the Heart and Circulation in Disease; Estimations of Basal Cardiac Output, Metabolism, Heart Size, and Blood Pressure in 235 Subjects

A history of the evolution of guidelines for reporting medical research: the long road to the EQUATOR Network

The Effect of Hyperthermia on the Distribution of Water and Electrolytes in Brain, Muscle and Liver 1

Contact Info

Product

Resources

About