Application of solid lipid nanoparticles as a long-term drug delivery platform for intramuscular and subcutaneous administration: In vitro and in vivo evaluation

Rat synovial tissue and blood rapamycin pharmacokinetics after intra-articular injection of free solution or nanoparticles vs free rapamycin intravenous shot

“…Our study observed a tenfold lower synovial membrane kel for NPs than for free rapamycin. Thus, the ability of NPs to release rapamycin in a prolonged manner at the site of action of rapamycin NPs allows them to be defined as long-acting systems (Elbrink et al, 2021). These T1/2 agree with the literature since specific sustained-release systems increase the half-life by 10 to 30 times compared to the free form (Rahimi et al, 2021).…”

Recent Progress of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers as Ocular Drug Delivery Platforms

“…An excellent review summarizing the feasibility of all the aforementioned lipid-based nanocarriers in ophthalmology is provided here [ 109 ]. Emerging initially as an alternative to liposomes in terms of their superior physical stability, cost-effective process and materials, as well as being alternatives to polymeric nanoparticles, due to the absence of toxic degradation products, [ 37 ] SLNs have been explored as drug delivery systems for various routes of application—dermal [ 110 , 111 ], ocular [ 112 , 113 ], pulmonary [ 114 ], parenteral [ 115 ], nasal [ 116 ], and oral [ 117 ]. Another advantageous characteristic of the lipid nanocarriers is the possibility of encapsulating more than one therapeutic agent, leading to the elaboration of dual or multidrug lipid nanoparticles, characterized by a synergetic effect and improved therapeutic performance [ 118 ].…”

Effects of Microencapsulated Ferulic Acid or Its Prodrug Methyl Ferulate on Neuroinflammation Induced by Muramyl Dipeptide

“…In particular, tristearin based SLMs can be proposed for intramuscular administration against neuroinflammation related to peripheral neuropathic pain. Solid lipid particulate systems are indeed known as a drug delivery platform for intramuscular and subcutaneous administration, to optimize the therapeutic effects of drugs, both at local and systemic levels [ 55 , 56 , 57 ]. Therefore, the intramuscular administration of the tristearin based SLMs loaded with Fer or Fer-Me may be proposed against neuroinflammation related to peripheral neuropathic pain, which currently requires the targeting of the neuroimmune interface for its management [ 5 ].…”