Application of single-cell sequencing to the research of tumor microenvironment

Chen, Sijie; Zhou, Zhiqing; Li, Yu; Du, Yuhui; Chen, Guoan

doi:10.3389/fimmu.2023.1285540

Cited by 6 publications

(3 citation statements)

References 206 publications

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“…There has been a persistent rising trend in article numbers within such a niche since this topic emerged in 2005. Especially in recent years, the volume of publications has surged, which may be attributed to the technological innovations in this field, such as single-cell sequencing ( 21 ). This new appreciation of the biology of TNBC has already led to the development of novel targeted agents, including PARP inhibitors, antibody-drug conjugates and immune-checkpoint inhibitors, which are revolutionizing the therapeutic landscape and providing new opportunities both for patients with early-stage TNBC and for those with advanced-stage disease ( 22 ).…”

Section: Discussionmentioning

confidence: 99%

Global research trends and prospects related to tumor microenvironment within Triple Negative Breast Cancer: a bibliometric analysis

Li,

Tong

et al. 2023

Front. Immunol.

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Background and aimsThe tumor microenvironment (TME) has pivotal parts within multiple tumor models of onset/progression, such as triple-negative breast cancer (TNBC). This bibliometric analysis was developed to explore trends and research niches revolving around TME in TNBC.MethodsWeb of Science Core Collection was queried for identifying studies linked with TME in TNBC, after which the VOSviewer, CiteSpace, and R software programs were used to conduct bibliometric analyses and to generate corresponding visualizations.ResultsIn total, this study included 1,604 studies published from 2005-2023. The USA and China exhibited the highest numbers of citations, and the research institutions with the greatest output in this field included Harvard University, the University of Texas System, and Fudan University. Ying Wang from Sun Yat-Sen University was the most published and most cited author in this space. The highest number of articles were published in Cancer, while the greatest co-citation number was evident in Breast Cancer Research. Important keywords related to this research topic included metastasis, tumor-infiltrating lymphocytes, immunotherapy, chemotherapy, and nanoparticles. In particular, pembrolizumab, immunotherapy, nanoparticles, combination treatment, and biomarkers were topics of marked interest in recent reports.ConclusionThe TME in TNBC is an area of rapidly growing and evolving research interest, with extensive global collaboration helping to drive this field forward. Antitumor therapies targeting the TME in TNBC patients represent an emerging topic of future research, providing opportunities for translational findings. The results of this analysis may provide additional guidance for work focused on the TME in TNBC.

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Section: Discussionmentioning

confidence: 99%

Global research trends and prospects related to tumor microenvironment within Triple Negative Breast Cancer: a bibliometric analysis

Li,

Tong

et al. 2023

Front. Immunol.

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“…Furthermore, SCS requires a small sample size, thus making it suitable for analyzing circulating tumor cells in liquid biopsy specimens [ 68 ]. However, these techniques have not yet been implemented in clinical routine and require technical refinement, standardization, and cost reduction to have a practical impact [ 69 , 70 ]. In GC, research in this area is in its early stages, but promising results have been obtained [ 71 , 72 , 73 ].…”

Section: Gastric Cancer Characterization Prognosis and Management In ...mentioning

confidence: 99%

Molecular Classifications in Gastric Cancer: A Call for Interdisciplinary Collaboration

Díaz del Arco,

Fernández Aceñero,

Ortega Medina

2024

IJMS

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Gastric cancer (GC) is a heterogeneous disease, often diagnosed at advanced stages, with a 5-year survival rate of approximately 20%. Despite notable technological advancements in cancer research over the past decades, their impact on GC management and outcomes has been limited. Numerous molecular alterations have been identified in GC, leading to various molecular classifications, such as those developed by The Cancer Genome Atlas (TCGA) and the Asian Cancer Research Group (ACRG). Other authors have proposed alternative perspectives, including immune, proteomic, or epigenetic-based classifications. However, molecular stratification has not yet transitioned into clinical practice for GC, and little attention has been paid to alternative molecular classifications. In this review, we explore diverse molecular classifications in GC from a practical point of view, emphasizing their relationships with clinicopathological factors, prognosis, and therapeutic approaches. We have focused on classifications beyond those of TCGA and the ACRG, which have been less extensively reviewed previously. Additionally, we discuss the challenges that must be overcome to ensure their impact on patient treatment and prognosis. This review aims to serve as a practical framework to understand the molecular landscape of GC, facilitate the development of consensus molecular categories, and guide the design of innovative molecular studies in the field.

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“…Importantly, such an approach has shown promising results in clinical trials [113]. Furthermore, although studies have been performed to describe the transcriptomic profiles of APCs interacting with T cells in the TME [228,229], there remains to elucidate the expression profile of NKTs in this context, thereby allowing for new strategies focused on tackling particular features of the diverse types of tumor cells to boost NKTs anti-tumoral capacity [230][231][232][233].…”

Section: Challenges and Future Prospects Of Inkt-based Immunotherapymentioning

confidence: 99%

Natural Killer T Cell Diversity and Immunotherapy

Tognarelli,

Gutiérrez-Vera,

Palacios

et al. 2023

Cancers

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Invariant natural killer T cells (iNKTs), a type of unconventional T cells, share features with NK cells and have an invariant T cell receptor (TCR), which recognizes lipid antigens loaded on CD1d molecules, a major histocompatibility complex class I (MHC-I)-like protein. This interaction produces the secretion of a wide array of cytokines by these cells, including interferon gamma (IFN-γ) and interleukin 4 (IL-4), allowing iNKTs to link innate with adaptive responses. Interestingly, molecules that bind CD1d have been identified that enable the modulation of these cells, highlighting their potential pro-inflammatory and immunosuppressive capacities, as required in different clinical settings. In this review, we summarize key features of iNKTs and current understandings of modulatory α-galactosylceramide (α-GalCer) variants, a model iNKT cell activator that can shift the outcome of adaptive immune responses. Furthermore, we discuss advances in the development of strategies that modulate these cells to target pathologies that are considerable healthcare burdens. Finally, we recapitulate findings supporting a role for iNKTs in infectious diseases and tumor immunotherapy.

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Application of single-cell sequencing to the research of tumor microenvironment

Cited by 6 publications

References 206 publications

Global research trends and prospects related to tumor microenvironment within Triple Negative Breast Cancer: a bibliometric analysis

Global research trends and prospects related to tumor microenvironment within Triple Negative Breast Cancer: a bibliometric analysis

Molecular Classifications in Gastric Cancer: A Call for Interdisciplinary Collaboration

Natural Killer T Cell Diversity and Immunotherapy

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