Application of Scanning Electrochemical Microscopy in Bioanalytical Chemistry

Nagy, Lı́via; Nagy, Géza

doi:10.1007/11663_2016_5

Cited by 5 publications

(4 citation statements)

References 144 publications

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“…The tip interacts with the surface under investigation and physical quantities such as current or potential are determined. SEPM has been employed for electrochemical studies in corrosion, − single-cells, − batteries, − bioelectrocatalysis, − and electrocatalysis. , Generally, the working principle of all SEPM techniques hinges on the precise positioning of a localized probe (the SEPM tip) to interact with a surface under interrogation, allowing one to image and manipulate the surface with submicron, nanometer and/or atomic scale precision. − To this end, the SEPM tip plays a central role in SEPM measurements because its properties (size and shape) define the resolution and applicability of the particular SEPM technique . Note, millimeter resolution and nonscanning techniques such as the scanning vibrating electrode technique (SVET) − and single nanoparticle electrochemical impact (SNEI) measurements, − which, although powerful tools used to investigate corrosion and electron-transfer processes, are not included in this review.…”

Section: Backstage: Principles and Applicability Of Operando Sepmmentioning

confidence: 99%

Operando Scanning Electrochemical Probe Microscopy during Electrocatalysis

et al. 2023

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Scanning electrochemical probe microscopy (SEPM) techniques can disclose the local electrochemical reactivity of interfaces in single-entity and sub-entity studies. Operando SEPM measurements consist of using a SEPM tip to investigate the performance of electrocatalysts, while the reactivity of the interface is simultaneously modulated. This powerful combination can correlate electrochemical activity with changes in surface properties, e.g., topography and structure, as well as provide insight into reaction mechanisms. The focus of this review is to reveal the recent progress in local SEPM measurements of the catalytic activity of a surface toward the reduction and evolution of O2 and H2 and electrochemical conversion of CO2. The capabilities of SEPMs are showcased, and the possibility of coupling other techniques to SEPMs is presented. Emphasis is given to scanning electrochemical microscopy (SECM), scanning ion conductance microscopy (SICM), electrochemical scanning tunneling microscopy (EC-STM), and scanning electrochemical cell microscopy (SECCM).

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Section: Backstage: Principles and Applicability Of Operando Sepmmentioning

confidence: 99%

Operando Scanning Electrochemical Probe Microscopy during Electrocatalysis

et al. 2023

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“…71 Even staunch supporters of more robust forms of transitional justice acknowledge the inherent difficulty of attaching the transitional justice label to efforts aimed at addressing historical injustices in established democracies. 72 Padraig McAuliffe calls established democracies 'far removed from that of a paradigmatic transition.' 73 He advocates for the retention of an orthodox conception of transition, one that excludes peaceful, liberal democracies.…”

Section: The Mmiwg Inquiry: a Transitional Justice Response?mentioning

confidence: 99%

Closing the cultural rights gap in transitional justice: Developments from Canada’s National Inquiry into Missing and Murdered Indigenous Women and Girls

Luoma

2021

Netherlands Quarterly of Human Rights

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Canada’s National Inquiry into Missing and Murdered Indigenous Women and Girls (the ‘MMIWG Inquiry’) is the latest truth-seeking body to grapple with legacies of violence against indigenous peoples in settler colonial states. While the name, Missing and Murdered, ostensibly limits its scope of application to bodily integrity crimes, the MMIWG Inquiry instead embraced an expansive understanding of violence to encompass gross violations of indigenous cultural rights and cultural harm more generally. This article argues that this holistic approach represents a stark departure from mainstream transitional justice models which have overwhelmingly prioritised the redress of a limited set of civil and political rights violations, while neglecting the underlying structural violence and cultural harm that permeates divided societies. This article advances a case to understand the MMIWG Inquiry as a transitional justice mechanism and draws upon its Final Report to analyse how truth commissions can engage with cultural rights violations in more meaningful ways. By directly and robustly accounting for indigenous cultural harm, the MMIWG Inquiry challenged the conventional parameters of the field and demonstrated the opportunity and utility of addressing cultural rights violations through a transitional justice framework.

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“…Scanning electrochemical microscopy (SECM) is an attractive technique for localized measurements [ [11] , [12] , [13] , [14] , [15] ], and has been used to investigate enzymatic and cellular activity, respiration activity in bovine embryonic cells, tumors, and bacteria, and oxidative imbalance effects on cells [ [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] ], among other biological applications [ 26 , 27 ]. We have also shown that SECM images can be employed as a tool to qualitatively map oxygen consumption in the vicinity of single human cells, revealing heterogeneous mitochondrial respiratory activity within a population of cells [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Unveiling the contribution of the reproductive system of individual Caenorhabditis elegans on oxygen consumption by single-point scanning electrochemical microscopy measurements

Santos

Macedo

Kowaltowski

et al. 2021

Analytica Chimica Acta

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Metabolic analysis in animals is usually either evaluated as whole-body measurements or in isolated tissue samples. To reveal tissue specificities in vivo , this study uses scanning electrochemical microscopy (SECM) to provide localized oxygen consumption rates (OCRs) in different regions of single adult Caenorhabditis elegans individuals. This is achieved by measuring the oxygen reduction current at the SECM tip electrode and using a finite element method model of the experiment that defines oxygen concentration and flux at the surface of the organism. SECM mapping measurements uncover a marked heterogeneity of OCR along the worm, with high respiration rates at the reproductive system region. To enable sensitive and quantitative measurements, a self-referencing approach is adopted, whereby the oxygen reduction current at the SECM tip is measured at a selected point on the worm and in bulk solution (calibration). Using genetic and pharmacological approaches, our SECM measurements indicate that viable eggs in the reproductive system are the main contributors in the total oxygen consumption of adult Caenorhabditis elegans . The finding that large regional differences in OCR exist within the animal provides a new understanding of oxygen consumption and metabolic measurements, paving the way for tissue-specific metabolic analyses and toxicity evaluation within single organisms.

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Application of Scanning Electrochemical Microscopy in Bioanalytical Chemistry

Cited by 5 publications

References 144 publications

Operando Scanning Electrochemical Probe Microscopy during Electrocatalysis

Operando Scanning Electrochemical Probe Microscopy during Electrocatalysis

Closing the cultural rights gap in transitional justice: Developments from Canada’s National Inquiry into Missing and Murdered Indigenous Women and Girls

Unveiling the contribution of the reproductive system of individual Caenorhabditis elegans on oxygen consumption by single-point scanning electrochemical microscopy measurements

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