Application of Rapid Dual Tracer Dilution Techniques for the Study of Endothelial Cell Amino Acid Transport in Perfused Microcarrier Cultures

Mann, Giovanni E.; Sheriff, C. J.; Toothill, Valerie J.; Jd, Pearson

doi:10.1007/978-1-4757-9601-8_23

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“…Endothelial cells take up L-arginine by the y + saturable transport system, which is inhibited competitively by L-NMMA, ADMA, SDMA and other cationic amino acids [10,[44][45][46]. However, only L-NMMA and ADMA exert a potent inhibitory action upon NOS; SDMA has no effect.…”

Section: Discussionmentioning

confidence: 99%

Nitric oxide synthase inhibitors and hypertension in children and adolescents

Goonasekera

Rees

Woolard

et al. 1997

Journal of Hypertension

139

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Section: Discussionmentioning

confidence: 99%

Nitric oxide synthase inhibitors and hypertension in children and adolescents

Goonasekera

Rees

Woolard

et al. 1997

Journal of Hypertension

139

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show abstract

Identification of inhibitors of nitric oxide synthase that do not interact with the endothelial cell l‐arginine transporter

Bogle

Moncada

Pearson

et al. 1992

British J Pharmacology

170

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The effects of inhibitors of nitric oxide (NO) synthase and other cationic amino acids on unidirectional L-arginine transport were studied in porcine aortic endothelial cells cultured in microwell plates or perfused in microcarrier columns. L-Homoarginine, L-lysine and L-ornithine inhibited transport of L-arginine. The NO synthase inhibitors NG-monomethyl-L-arginine and N0-iminoethyl-L-ornithine also reduced L-arginine uptake, whereas NG-nitro-L-arginine and its methyl-ester had no inhibitory effect. The ability to modulate selectively endothelial cell L-arginine transport or NO synthase activity will allow further characterization of the arginine transporter and its role in regulating NO biosynthesis.

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Application of Rapid Dual Tracer Dilution Techniques for the Study of Endothelial Cell Amino Acid Transport in Perfused Microcarrier Cultures

Cited by 2 publications

References 54 publications

Nitric oxide synthase inhibitors and hypertension in children and adolescents

Nitric oxide synthase inhibitors and hypertension in children and adolescents

Identification of inhibitors of nitric oxide synthase that do not interact with the endothelial cell l‐arginine transporter

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