Application of quantum cascade lasers to trace gas analysis

Kosterev, Anatoliy A.; Wysocki, Gerard; Bakhirkin, Yury A.; So, Stephen; Lewicki, R.; Fraser, Matthew P.; Tittel, Frank K.; Curl, R. F.

doi:10.1007/s00340-007-2846-9

Cited by 337 publications

(172 citation statements)

References 60 publications

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“…Because they require relatively low power and are so small, QCL-based systems may eventually replace larger and slower FTIR and other spectroscopy systems for laboratory work and may thus, with further development, have a more applicable role in a clinical-based setting. Such clinical application requires extremely fast sampling times, relatively small size (i.e., volume or mass), and accurate results in order to avoid misdiagnosis [75]. QCL mechanisms are based on intersubband-transitions of electrons inside a quantum-well structure.…”

Section: Diabetesmentioning

confidence: 99%

Vibrational spectroscopy of biofluids for disease screening or diagnosis: translation from the laboratory to a clinical setting

Mitchell

Gajjar

Theophilou

et al. 2014

Journal of Biophotonics

136

108

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There remains a need for objective and cost‐effective approaches capable of diagnosing early‐stage disease in point‐of‐care clinical settings. Given an increasingly ageing population resulting in a rising prevalence of chronic diseases, the need for screening to facilitate the personalising of therapies to prevent or slow down pathology development will increase. Such a tool needs to be robust but simple enough to be implemented into clinical practice. There is interest in extracting biomarkers from biofluids (e.g., plasma or serum); techniques based on vibrational spectroscopy provide an option. Sample preparation is minimal, techniques involved are relatively low‐cost, and data frameworks are available. This review explores the evidence supporting the applicability of vibrational spectroscopy to generate spectral biomarkers of disease in biofluids. We extend the inter‐disciplinary nature of this approach to hypothesise a microfluidic platform that could allow such measurements. With an appropriate lightsource, such engineering could revolutionize screening in the 21st century. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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Section: Diabetesmentioning

confidence: 99%

Vibrational spectroscopy of biofluids for disease screening or diagnosis: translation from the laboratory to a clinical setting

Mitchell

Gajjar

Theophilou

et al. 2014

Journal of Biophotonics

136

108

View full text Add to dashboard Cite

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“…Although even better detection limit is expected with longer exposure duration in low temperature TPD, much better detection limit (pptv) has already been established by other recent techniques. These are the case of, for example, trace gas analysis using quantum cascade lasers 23 and cavity ringdown spectroscopy (CRDS). 24 These are absorption spectroscopy-based techniques, and therefore, analytes are limited by the availability of probe laser light at the appropriate wavelength.…”

Section: Comparison With Other Gas Analytical Techniquesmentioning

confidence: 99%

Temperature Programmed Desorption of Quench-condensed Krypton and Acetone in Air; Selective Concentration of Ultra-trace Gas Components

Suzuki

Sakaguchi

2016

ANAL. SCI.

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Selective concentration of ultra-trace components in air-like gases has an important application in analyzing volatile organic compounds in the gas. In the present study, we examined quench-condensation of the sample gas on a ZnO substrate below 50 K followed by temperature programmed desorption (TPD) (low temperature TPD) as a selective gas concentration technique. We studied two specific gases in the normal air; krypton as an inert gas and acetone as a reactive gas. We evaluated the relationship between the operating condition of low temperature TPD and the lowest detection limit. In the case of krypton, we observed the selective concentration by exposing at 6 K followed by thermal desorption at about 60 K. On the other hand, no selectivity appeared for acetone although trace acetone was successfully concentrated. This is likely due to the solvent effect by a major component in the air, which is suggested to be water. We suggest that pre-condensation to remove the water component may improve the selectivity in the trace acetone analysis by low temperature TPD.

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“…Optical sources in the mid-infrared (mid-IR) wavelength range are important for applications including trace gas sensing, explosive detections, spectroscopy and free space communications [1][2][3][4]. Mid-IR quantum cascade laser (QCL) is in unique position to be utilized for these applications.…”

Section: Introductionmentioning

confidence: 99%

Widely Tunable Monolithic Mid-Infrared Quantum Cascade Lasers Using Super-Structure Grating Reflectors

Guo

Cheng

et al. 2016

Photonics

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Abstract:A monolithic, three-section, and widely tunable mid-infrared (mid-IR) quantum cascade laser (QCL) is demonstrated. This electrically tuned laser consists of a gain section placed between two super structure grating (SSG) distributed Bragg reflectors (DBRs). By varying the injection currents to the two grating sections of this device, its emission wavelength can be tuned from 4.58 µm to 4.77 µm (90 cm´1) with a supermode spacing of 30 nm. This type of SSG-DBR QCLs can be a compact replacement for the external cavity QCL. It has great potential to achieve gap-free and even further tuning ranges for sensor applications.

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Application of quantum cascade lasers to trace gas analysis

Cited by 337 publications

References 60 publications

Vibrational spectroscopy of biofluids for disease screening or diagnosis: translation from the laboratory to a clinical setting

Vibrational spectroscopy of biofluids for disease screening or diagnosis: translation from the laboratory to a clinical setting

Temperature Programmed Desorption of Quench-condensed Krypton and Acetone in Air; Selective Concentration of Ultra-trace Gas Components

Widely Tunable Monolithic Mid-Infrared Quantum Cascade Lasers Using Super-Structure Grating Reflectors

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