Application of quantitative analysis of multi-component system approach for determination of ginsenosides in different mass-spectrometric conditions

Stekolshchikova, Elena; Turova, Polina; Шпигун, О. А.; Родин, И. А.; Ставрианиди, А. Н.

doi:10.1016/j.chroma.2018.09.005

Cited by 19 publications

(16 citation statements)

References 15 publications

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“…In recent years, interest in the contributions of bioactive compounds (such as phenolic acids, ginsenosides, rutin, and flavonoids) to human well-being has increased dramatically. − In addition to reported anti-inflammatory, antimicrobial, and anti-enzymatic benefits, bioactive compounds are vital for the development of new medicines . Organic solvents have previously been used to extract bioactive compounds from various sample matrices .…”

Section: Introductionmentioning

confidence: 99%

Investigation of Deep Eutectic Solvent-Based Microwave-Assisted Extraction and Efficient Recovery of Natural Products

Wang

Jing

Tian

et al. 2020

ACS Sustainable Chem. Eng.

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A systematic study of the principles of deep eutectic solvent-based microwave-assisted extraction (DES-MAE) was performed. It was found that the heating rates of most DESs decreased (heat capacity increased) under microwave irradiation with increasing water content, allowing high-efficiency extraction for thermally sensitive compounds. In addition, DESs containing carboxylic acids reacted with hydroxyl groups of sugar and choline chloride, resulting in cell wall destruction and inhibition of cellulose, hemicellulose, and lignin reconnection in cell walls through hydrogen bonds, thus leading to better extraction performance. This was verified by extracting anthraquinones from Rheum palmatum using DES-MAE and optimizing extraction conditions. DES with citric acid as the hydrogen bonding donor gave the highest extraction efficiency under the optimized conditions. In addition, anthraquinones in the DES extract were recovered using three kinds of silica modified by different functional groups. The results showed that material containing a phenyl group is beneficial to the recovery of anthraquinones in acid-based DESs because it can facilitate strong hydrophobic and π−π interactions. This study showcases the green chemistry applications of DES-MAE in a laboratory and industry alike, and demonstrates the recovery of natural products from DES extracts. The findings also provide valuable information for green extraction, modification, and application of cellulose, hemicellulose, and lignin.

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Section: Introductionmentioning

confidence: 99%

Investigation of Deep Eutectic Solvent-Based Microwave-Assisted Extraction and Efficient Recovery of Natural Products

Wang

Jing

Tian

et al. 2020

ACS Sustainable Chem. Eng.

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“…The latest research evaluated and discussed the volatility and stability of RCFs by using 19 kinds of ginsenosides as reference standards under different MS conditions (different HPLC-MS instruments and different de-aggregation potentials). This study found that the RCF had enough reproducibility under a wide range of changes to verify the rationality of simultaneous determination of 19 ginsenosides using a single test and multiple evaluation methods [126]. Another study used a relative response factor method and a UV-MS gradient elution method to determine the content of ginsenosides in ginseng extract and ginseng products.…”

Section: Qamsmentioning

confidence: 80%

Recent Advances in Separation and Analysis of Saponins in Natural Products

Wang

et al. 2022

Separations

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To better control the quality of saponins, ensure their biological activity and clinical therapeutic effect, and expand the development and application of saponins, this paper systematically and comprehensively reviews the separation and analytical methods of saponins in the past decade. Since 2010, the electronic databases of PubMed, Google Scholar, ISI Web of Science, Science Direct, Wiley, Springer, CNKI (National Knowledge Infrastructure, CNKI), Wanfang Med online, and other databases have been searched systematically. As a result, it is found that ionic liquids and high-performance countercurrent chromatography are the most popular extraction and separation techniques for saponins, and the combined chromatography technique is the most widely used method for the analysis of saponins. Liquid chromatography can be used in combination with different detectors to achieve qualitative or quantitative analysis and quality control of saponin compounds in medicinal materials and their preparations. This paper provides the latest valuable insights and references for the analytical methods and continued development and application of saponins.

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“…In this approach, one or several reference substances are used as standards to control other components using established relative response factors and relative retention times 8 . QAMS has been successfully applied in HPLC‐MS measurements; however, the stability of such relative response factors highly depends on the instrument and detection conditions 13–15 . Previously, we have demonstrated that relative response factors could be different depending on ion source and other MS conditions; therefore, they should be established for a particular instrument 15 .…”

Section: Introductionmentioning

confidence: 99%

An application of the standardised reference extract quantification strategy in the quality control of ginseng infusions by liquid chromatography with mass spectrometric detection

Semenova

Bryskina

Cvetanović

et al. 2022

Phytochemical Analysis

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Introduction Limited availability of individual standards is a bottleneck for quality control of functional foods and natural medicines. The use of standard mixtures or secondary standards is a possible alternative in this case. Earlier, an approach known as standardised reference extract (RE) strategy was introduced for HPLC‐UV analysis of different plant materials; however, its application in HPLC‐MS analysis has not been investigated. Objective To establish an HPLC‐MS‐based RE method for determination of ginsenoside content in ginseng infusions using commercially available extract reference material of Panax quinquefolius L. Results The developed HPLC‐MS method was validated as precise (1.1%–9.4% intra‐day variation; 1.6%–12.8% inter‐day variation) and highly sensitive [limit of detection (LOD): 1–40 ng/mL; limit of quantification (LOQ): 4–120 ng/mL]. The stability of samples was satisfactory (5.7%–16.3%). The RE quantification method was compared with the external standard method, and the obtained difference was not significant, mostly in the range of 5%–10%. Matrix effects for the diluted samples of RE and ginseng infusions, determined via the standard addition method, were in the range of 85%–115% and 80%–126%, respectively, and were also positively correlated with the ginsenoside concentration. Eleven batches of ginseng infusions from different manufacturers were analysed using the established method. Conclusion The method for HPLC‐MS‐based ginsenoside quantification using RE as a secondary standard was established for the first time. The results of this study demonstrate that the application of the standardised RE strategy in HPLC‐MS can minimise the matrix effect‐related error in addition to the cost‐effective quality control of herbal products, foods, and traditional medicines.

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Application of quantitative analysis of multi-component system approach for determination of ginsenosides in different mass-spectrometric conditions

Cited by 19 publications

References 15 publications

Investigation of Deep Eutectic Solvent-Based Microwave-Assisted Extraction and Efficient Recovery of Natural Products

Investigation of Deep Eutectic Solvent-Based Microwave-Assisted Extraction and Efficient Recovery of Natural Products

Recent Advances in Separation and Analysis of Saponins in Natural Products

An application of the standardised reference extract quantification strategy in the quality control of ginseng infusions by liquid chromatography with mass spectrometric detection

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