Abstract:The present study deals with the formulation of mucoadhesive bilayered buccal film of lidocaine hydrochloride and benzydamine hydrochloride for treatment of oral ulcers (aphthous stomatitis). Eudragit-RLPO and Ethyl cellulose were used as film forming polymers and low viscosity grade hydroxyl propyl cellulose as a mucoadhesive agent. Solvent casting method was adopted for film formation. The film was evaluated for content uniformity, tensile strength, folding endurance, swelling, mucoadhesive strength, ex vivo… Show more
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