Application of PVP/HPMC miscible blends with enhanced mucoadhesive properties for adjusting drug release in predictable pulsatile chronotherapeutics

Karavas, Evangelos; Georgarakis, E.; Bikiaris, Dimitrios N.

doi:10.1016/j.ejpb.2005.12.013

Cited by 129 publications

(71 citation statements)

References 42 publications

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“…PVP is remarkable due to its ability to interact with a wide variety of hydrophilic and hydrophobic materials and has properties similar to those of a protein due to its pyrrolidone structure. This material exhibits low immunogenicity, antigenicity and very low toxicity [27][28][29] . This material is used in a wide variety of applications and it is interesting from a biological point of view, since it has structural features similar to those of proteins, and has great potential for applications in the medical field [28][29][30] .…”

Section: Introductionmentioning

confidence: 99%

Electrospinning of Gelatin/Poly (Vinyl Pyrrolidone) Blends from Water/Acetic Acid Solutions

2015

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Electrospinning is a versatile and efficient technique for obtaining polymeric microfibers and nanofibers with great potential for applications in tissue engineering, biosensors, filtration, wound dressings, controlled drug release and enzyme immobilization. Electrospun fibers are obtained by applying an electric field in a polymer solution resulting in non-woven fibrous mats with high surface area relative to volume and high porosity. In this work, the electrospinning of gelatin/poly(vinyl pyrrolidone) (PVP) blends was investigated. The polymers were electrospun from solutions containing different concentrations of water and acetic acid. Solutions were characterized by measuring the pH, electrical conductivity, surface tension and viscosity. The influence of acetic acid concentration in solution properties and its influence in the spinnability were investigated. The resulting non-woven membranes were characterized by using scanning electron microscopy (SEM), thermogravimetric analysis (TG) and cytotoxicity.

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Section: Introductionmentioning

confidence: 99%

Electrospinning of Gelatin/Poly (Vinyl Pyrrolidone) Blends from Water/Acetic Acid Solutions

2015

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“…In a previous study, HPMC showed a slow drug-release behavior 19) . Therefore, we added various concentrations of PVP in the pilot test and, finally, 90% of PVP was considered the most appropriate for application in this study 14) . For the mucoadhesion property, we added 10% of HPMC in the FA group.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, we have selected a specially designed buccal film. Ethyl cellulose (EC) was used as the backing layer and hydroxypropyl methylcellulose (HPMC) and polyvinylpyrrolidone (PVP) were used as the drug-containing layer [10][11][12][13][14] . Therefore, the aim of this study was to develop a bi-layered strip consisting of a tooth-adhesive layer and a non-adhesive protective layer to deliver lidocaine.…”

Section: Introductionmentioning

confidence: 99%

The <i>in vitro</i> and <i>in vivo</i> effects of a fast-dissolving mucoadhesive bi-layered strip as topical anesthetics

et al. 2016

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To overcome pain on injection, the dentist can apply a topical anesthetic spray. Despite the convenience, it is not easy to apply it locally. So, we developed an oral mucoadhesive bi-layer film containing an anesthetic. We used polyvinylpyrrolidone (PVP)/ hydroxypropyl methylcellulose (HPMC) and HPMC-only layer as the drug-containing layer and ethyl cellulose (EC) as the backing layer. The lidocaine released was tested in vitro together with the adhesion time and cytotoxicity of the film. Mucosa permeability was tested in vivo. Statistical analysis was performed, with p at 0.05 taken to be significant. The lidocaine was released significantly faster in the PVP/HPMC than HPMC-only group and 80% of the drug was released within 1 min (p<0.05) and they attached at least 3 h. The test groups showed no toxicity and the drug effectively permeated the mucosa (p<0.05). We suggest this new mucoadhesive anesthetic may reduce dental phobia.

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“…The morning BP surge was reported to be associated with high risk of cardiac death, and ischemic and hemorrhagic stroke (Nayak et al, 2009;Cohen et al, 1997;Behrens et al, 1997). Blood pressure which arises notably just before waking up is usually responsible for these attacks and deaths (Karavas et al, 2006). Therefore, the chronotherapeutic drug delivery approach should be the ideal remedy for the treatment of hypertension in order to tackle the early morning mortality associated with such disease state.…”

Section: Introductionmentioning

confidence: 99%

Design and optimization of self-microemulsifying drug delivery system (SMEDDS) of felodipine for chronotherapeutic application

Storti-Filho

Damke

Carrara

et al. 2014

Braz. J. Pharm. Sci.

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The objective of this research work was to design, develop and optimize the self micro-emulsifying drug delivery system (SMEDDS) of Felodipine (FL) filled in hard gelatine capsule coated with polymer in order to achieve rapid drug release after a desired time lag in the management of hypertension. Microemulsion is composed of a FL, Lauroglycol FCC, Transcutol P and Cremophor EL. The optimum surfactant to co-surfactant ratio was found to be 2:1. The resultant microemulsions have a particle size in the range of 65-85 nm and zeta potential value of -13.71 mV. FL release was adequately adjusted by using pH independent polymer i.e. ethyl cellulose along with dibutyl phthalate as plasticizer. Influence of formulation variables like viscosity of polymer, type of plasticizer and percent coating weight gain was investigated to characterize the time lag. The developed formulation of FL SMEDDS capsules coated with ethyl cellulose showed time lag of 5-7 h which is desirable for chronotherapeutic application.Uniterms: Felodipine/self-microemulsifying delivery. Felodipine/chronotherapeutic application. Selfmicroemulsifying drug delivery system/development. Drugs/controlled release. Ethyl cellulose/drugs coated. Hypertension/treatment. Chronotherapeutics/hypertension treatment.O objetivo desse trabalho de pesquisa foi planejar, desenvolver e otimizar sistema de liberação de fármaco auto-microemulsificante(SMEDDS) de felodipino (FL) em cápsulas de gelatina dura revestidas com polímero, a fim de obter liberação rápida após tempo desejado no manejo da hipertensão. A microemulsão é composta de FL, lauroglilcol FCC, Transcutol P e Cremophor EL. A proporção ótima de tensoativo e de co-tensoativo foi de 2:1. As microemulsões resultantes têm tamanho de partícula na faixa de 65-85 nm com potencial zeta de -13,71 mV. A liberação de FL foi ajustada adequadamente, utilizando-se polímero independente de pH, como etilcelulose com ftalato de dibutila como plastificante. A influência das variáveis da formulação, como viscosidade do polímero, tipo de plastificante e ganho percentual de peso do revestimento foi investigada para caracterizar o intervalo de tempo de liberação. A formulação de cápsulas de FL SMEDDS revestidas com etilcelulose mostrou intervalo de tempo de liberação de 5 a 7 horas, o que é desejável para uma aplicação cronoterapêutica.Uniterms: Felodipino/liberação de fármaco auto-emulsificante. Felodipino/aplicação cronoterapêutica. Sistema de liberação de fármaco auto-emulsificante/desenvolvimento. Fármacos/liberação controlada. Etilcelulose/revestimento de fármacos. Hipertensão/tratamento. Cronoterapia/tratamento da hipertensão.

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Application of PVP/HPMC miscible blends with enhanced mucoadhesive properties for adjusting drug release in predictable pulsatile chronotherapeutics

Cited by 129 publications

References 42 publications

Electrospinning of Gelatin/Poly (Vinyl Pyrrolidone) Blends from Water/Acetic Acid Solutions

Electrospinning of Gelatin/Poly (Vinyl Pyrrolidone) Blends from Water/Acetic Acid Solutions

The <i>in vitro</i> and <i>in vivo</i> effects of a fast-dissolving mucoadhesive bi-layered strip as topical anesthetics

Design and optimization of self-microemulsifying drug delivery system (SMEDDS) of felodipine for chronotherapeutic application

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