Application of purified bone morphogenetic protein (BMP) preparations in cranio-maxillo-facial surgery

Functional and aesthetic reconstruction of extensive oral ablative defects using temporalis muscle flap: A case report and a sort review

“…This material is extensively used in orthopaedic surgery for many years with an extremely high success rate. It represents a nearly ideal material for this application, as it is biocompatible, maintains its volume and position after its placement in the long-term, is readily available in large quantities, easily carved in a three-dimensional shape and carries no risk of rejection and a low chance of infection (Sailer and Kolb, 1994). Compared with other temporal implants, cold-cure acrylic is at an advantage as it is not prefabricated (Miloro, 2004) (so it can be custommoulded to reconstruct three-dimensional temporal defects of any shape and size), can be permanently fixed in the recipient area without using titanium miniscrews or sutures, contains gentamicin, is radio-opaque and inexpensive.…”

Measurement of total and local bone morphogenetic protein concentration in bone tumours

“…In this study we used a purified mixed bBMP as antigen in producing antiserum. The reason for using bovine rather than human bone as a source of crude BMP is mainly ethical; recent clinical studies with bBMP have produced satisfactory results in human experiments [18,19], and the antiserum of bBMP and hBMP crossreact 100% [26]. As the bone-inductive activity and importance of various BMPs remain unresolved [29,31], an antiserum against a crude BMP mixture is closer to the normal state when total amounts of BMP are measured.…”

“…BMPs have been shown to contribute to abnormal bone formation and its occurrence in malignant tissues can be used to determine prognosis [13,33,34], in addition to other factors such as sex [5,16,18], its site [2,5,6], its size [2,5,16], the duration of symptoms and histological subtype [5,16,17]. Yoshikawa et al detected BMP in only some samples of osteosarcoma; their patients with BMP-producing osteosarcoma had lung metastases more often than those with osteosarcoma which did not produce BMP [33,34].…”

Bone Morphogenetic Proteins in Craniofacial Surgery: Current Techniques, Clinical Experiences, and the Future of Personalized Stem Cell Therapy

“…Some of the earliest reports of the clinical use of BMPs partially purified from bovine bone describe successful application of these BMPs along with titanium implants or lyophilized cartilage in the reconstruction of various craniofacial deformities found the in Apert and Crouzon syndrome [124, 125]. Commercially available rhBMP-2 is only FDA approved for intraoral applications in the craniofacial skeleton; however, off-label use of rhBMP-2 and rhBMP-7 has been attempted in some cases to solve other particularly significant reconstructive challenges in the craniomaxillofacial skeleton [29, 48, 126, 127].…”