Application of Proteomics in Diagnosis of ADHD, Schizophrenia, Major Depression, and Suicidal Behavior

Alawam, Khaled

doi:10.1016/b978-0-12-800453-1.00009-9

Cited by 11 publications

(6 citation statements)

References 97 publications

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“…Recent evidence has suggested an important role of lipids in the aetiology and treatment of depression [48,49]. Modern analytical platforms have also been applied in depression biomarker research [50][51][52][53].…”

Section: Affective Disordersmentioning

confidence: 99%

Application of fatty acid and lipid measurements in neuropsychiatry

Grela

Rachel

Cole

et al. 2016

Clinical Chemistry and Laboratory Medicine (CCLM)

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Abstract:The importance of lipids in the understanding of disease states is constantly increasing. Whilst the link between metabolic disorders and lipids seems to be clear, interpreting lipid regulation in the context of neuropsychiatric disorders is a new approach. Mental disorders account for almost 15% of the total global disease burden with Alzheimer's disease, depression or schizophrenia being amongst the most widespread mental disorders in the general population. For this reason rapid and early diagnosis is crucial and finding the right biomarkers is of great importance. Lipids appear to be essential in learning the aetiopathology of neuropsychiatric diseases as well as in biomarker research as they are most abundantly present in the brain. This study discusses recent findings in neuropsychiatry in the context of lipid analysis.

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Section: Affective Disordersmentioning

confidence: 99%

Application of fatty acid and lipid measurements in neuropsychiatry

Grela

Rachel

Cole

et al. 2016

Clinical Chemistry and Laboratory Medicine (CCLM)

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“…In autism research, proteomics and metabolomics are leading towards new diagnostic and therapeutic perspectives [80][81][82]. The same is occurring for schizophrenia [83,84] or fibromyalgia [85,86]. Application of -omics strategies in these diseases have also involved the therapeutic monitoring of pharmacological response [87], nutritional aspects and microbioma evaluation [88].…”

Section: Sulfur Metabolism and -Omics Techniques In Asds Schizophrenia And Fibromyalgiamentioning

confidence: 99%

Sulfur Metabolism and Sulfur-Containing Amino Acids Derivatives Â– II: Autism Spectrum Disorders, Schizophrenia and Fibromyalgia

Palego

Betti²,

Giannaccini³

2015

Biochem Pharmacol (Los Angel)

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The metabolism of sulfur (S) compounds concurs to the maintain of cell homeostasis and tissue integrity in the human body. Sulfur chemical species act in all cells as anti-oxidant/scavenging agents or regulators of membrane stability/excitability. At the same time, they also exert tissue-dependent functions behaving as protective molecules of the liver and cardiovascular system, as modulators of the immune response, gut activity and CNS neurotransmitter signaling. The involvement of S compounds in human complex, chronic, disabling diseases at multifaceted pathogenesis is actually under investigation: altered levels of S metabolites could be in fact bio-indicators of impaired oxidation state in the body and their unbalance could be risk factors for disease onset. By the present review, we will discuss data from the literature which unearth an altered S biochemistry in human complex illnesses, taking as an example highly invalidating neuropsychiatry and pain perception diseases as autism spectrum disorders (ASD), schizophrenia and fibromyalgia. As well, we will depict herein the utility at applying to this area of the clinical research high resolving -omics strategies in combination with methodological tools which specifically explore S metabolism in patients. The perspectives of these kind of analyses would be the adoption of more valuable, personalized therapeutics protocols and, possibly, an improved bio-monitoring of patients, also including their response to treatments.

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“…Proteomic biomarkers can be used for distinguishing between comorbid psychiatric disorders in clinical setup as well as their potential for understanding mechanisms underlying the disorders and in discovery of new treatment strategies. Metabolomics, a highthroughput investigatory strategy developed in recent years, can offer comprehensive metabolite-level insights that complement protein and genetic findings [28][29][30].…”

Section: Proteomics and Metabolomicsmentioning

confidence: 99%

New Insights into the Pathogenesis and Pharmacogenomics of Attention Deficit Hyperactivity Disorder

2015

Metabolomics

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Application of Proteomics in Diagnosis of ADHD, Schizophrenia, Major Depression, and Suicidal Behavior

Cited by 11 publications

References 97 publications

Application of fatty acid and lipid measurements in neuropsychiatry

Application of fatty acid and lipid measurements in neuropsychiatry

Sulfur Metabolism and Sulfur-Containing Amino Acids Derivatives Â– II: Autism Spectrum Disorders, Schizophrenia and Fibromyalgia

New Insights into the Pathogenesis and Pharmacogenomics of Attention Deficit Hyperactivity Disorder

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