Application of protein/polysaccharide aerogels in drug delivery system: A review

Zhu, Yujun; Li, Hailun; Peng, Can; Ma, Jingrui; Huang, Shuqiang; Wang, Ruijie; Wu, Bingmin; Xiong, Qingping; Peng, Daiyin; Huang, Song; Chen, Jing

doi:10.1016/j.ijbiomac.2023.125727

Cited by 15 publications

(7 citation statements)

References 115 publications

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“…Achieving this specificity often involves surface modifications and the incorporation of targeting ligands, adding complexity to the design and synthesis processes. [ 160,161 ] While some level of stability is necessary to prevent premature drug release, excessive stability of some types of biopolymer aerogels may hinder the timely and controlled delivery of therapeutic agents. [ 162 ] Moreover, achieving an optimal level of biodegradability is crucial to avoid long‐term accumulation of aerogel in the body, which could lead to adverse effects.…”

Section: Issues and Challenges Of Biopolymer‐based Aerogels In Antica...mentioning

confidence: 99%

Revolutionizing Cancer Treatment: Biopolymer‐Based Aerogels as Smart Platforms for Targeted Drug Delivery

Alkhalidi,

Alahmadi,

Rizg

et al. 2024

Macromol. Rapid Commun.

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Cancer stands as a leading cause of global mortality, with chemotherapy being a pivotal treatment approach, either alone or in conjunction with other therapies. The primary goal these therapies is to inhibit the growth of cancer cells specifically, while minimizing harm to healthy dividing cells. Conventional treatments have been hampered by their side effects, often causing severe discomfort to patients. Researchers have been exploring innovative approaches to target cancer cells selectively. In this context, biopolymer‐based aerogels emerge as innovative platforms, showcasing unique properties that respond intelligently to diverse stimuli, including temperature, pH variations, magnetic fields, and redox potential. This responsiveness enables precise control over the release of anticancer drugs, enhancing therapeutic outcomes. The significance of these aerogels lies in their ability to offer targeted drug delivery with increased efficacy, biocompatibility, and a high drug payload. In this comprehensive review, we discuss the role of biopolymer‐based aerogels as an emerging functionalized platforms in anticancer drug delivery. The review addresses the unique properties of biopolymer‐based aerogels showing their smart behavior in responding to different stimuli including temperature, pH, magnetic and redox potential to control anticancer drug release. Finally, the review discusses the application of different biopolymer‐based aerogel in delivering different anticancer drugs and also discusses the potential of these platforms in gene delivery applications. This article is protected by copyright. All rights reserved

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Section: Issues and Challenges Of Biopolymer‐based Aerogels In Antica...mentioning

confidence: 99%

Revolutionizing Cancer Treatment: Biopolymer‐Based Aerogels as Smart Platforms for Targeted Drug Delivery

Alkhalidi,

Alahmadi,

Rizg

et al. 2024

Macromol. Rapid Commun.

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“…Optimizing every stage of production, from the extraction of raw materials to aerogel formation, is crucial. The introduction of novel processing techniques, such as continuous manufacturing processes, can minimize production costs [154][155][156][157][158]. Exploring the use of waste streams from other industries as feedstock for bio-based aerogels improves cost efficiency and is in line with the principles of the circular economy [157][158][159][160][161].…”

Section: Scalability and Cost-effectivenessmentioning

confidence: 99%

Hybrid Materials of Bio-Based Aerogels for Sustainable Packaging Solutions

Vrabič-Brodnjak

2023

Gels

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This review explores the field of hybrid materials in the context of bio-based aerogels for the development of sustainable packaging solutions. Increasing global concern over environmental degradation and the growing demand for environmentally friendly alternatives to conventional packaging materials have led to a growing interest in the synthesis and application of bio-based aerogels. These aerogels, which are derived from renewable resources such as biopolymers and biomass, have unique properties such as a lightweight structure, excellent thermal insulation, and biodegradability. The manuscript addresses the innovative integration of bio-based aerogels with various other materials such as nanoparticles, polymers, and additives to improve their mechanical, barrier, and functional properties for packaging applications. It critically analyzes recent advances in hybridization strategies and highlights their impact on the overall performance and sustainability of packaging materials. In addition, the article identifies the key challenges and future prospects associated with the development and commercialization of hybrid bio-based aerogel packaging materials. The synthesis of this knowledge is intended to contribute to ongoing efforts to create environmentally friendly alternatives that address the current problems associated with conventional packaging while promoting a deeper understanding of the potential of hybrid materials for sustainable packaging solutions.

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“…This capability enables researchers to adjust the composition of hydrogels, tailoring them to provide the desired responses under specific environmental conditions. Alongside carbohydrates, proteins are largely employed in the formulation of hydrogels, owing to their easily tailored characteristics for various applications such as controlled drug transport and release systems, materials with absorbent and antimicrobial properties in pharmacy, medicine, the food industry, and environmental protection [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…Freeze-drying is recognized for its ability to increase the porosity of the hydrogel, preserving the hydrogel's integrity and shape while preventing microbial growth due to water removal [23]. Lyophilization, or freeze-drying, involves a process for extracting moisture from a product at temperatures lower than typical freezing points by causing the ice to undergo sublimation and leading to the formation of cryogels lyophilized hydrogels [4]. These can be incorporated into various food items, such as desserts, ice creams, creams, and sausages as flavor carrier oleogels and then gradually release the components [5,24].…”

Section: Introductionmentioning

confidence: 99%

“…In contrast to conventional methods like warm air drying or ambient temperature drying, freeze-drying completely prevents the potential for natural microbial growth during the drying of organic materials [25], ensuring product stability. On the other hand, there is minimal shrinkage or deformation during the process, which also helps to enhance the absorbent properties [26] due to the large specific surface and high porosity [4]. Manzocco et al reported pore sizes on the order of micrometers for whey aerogels prepared using the supercritical drying (<1 µm) and freeze-drying (2-5 µm) methods [24], demonstrating that the drying process can influence the properties of whey-based hydrogels.…”

Section: Introductionmentioning

confidence: 99%

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The Influence of Lyophilization Pretreatment and Whey Content on Whey and Gelatin-Based Hydrogels

Lopes,

Fechete,

Minteuan

et al. 2024

Gels

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Whey and gelatin, natural polymers within the protein category, find widespread use in hydrogel formulations applied across the food, medical, and pharmaceutical industries. This study presents new characteristics of hydrogels based on whey, gelatin, and copper sulfate as a consequence of the additional steps in the preparation method, specifically refrigeration and freezing storage followed by lyophilization. The water state in hydrogels prior to lyophilization impacts the morphological appearance, with refrigerated hydrogels exhibiting a more regular and dense pore distribution, as shown by the Scanning Electron Microscopy (SEM) images. This observation aligns with the higher mobility of polymer chains indicated by T2 distributions in 1H nuclear magnetic resonance (RMN) relaxometry measurements. Changes in the intensity and amide-specific wavenumbers of the FTIR spectra of whey and gelatin proteins are evident in the Fourier Transformed Infrared (FTIR) spectra of crosslinked and frozen hydrogels before lyophilization. Moreover, the reinforcing effect in the hydrogel matrix, noted in mechanical tests, is attributed to increased polymer chain content and copper sulfate crosslinking.

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Application of protein/polysaccharide aerogels in drug delivery system: A review

Cited by 15 publications

References 115 publications

Revolutionizing Cancer Treatment: Biopolymer‐Based Aerogels as Smart Platforms for Targeted Drug Delivery

Revolutionizing Cancer Treatment: Biopolymer‐Based Aerogels as Smart Platforms for Targeted Drug Delivery

Hybrid Materials of Bio-Based Aerogels for Sustainable Packaging Solutions

The Influence of Lyophilization Pretreatment and Whey Content on Whey and Gelatin-Based Hydrogels

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