Application of postmortem MRI for identification of medulla oblongata contusion as a cause of death: a case report

Yang, Liyao; Liu, Haiyan; Zhao, Xin; Li, Hongyang; Zhou, Dandan; Wang, Bo; Li, Zhao; Wang, Lijun; Gao, Yanbin; Zhu, Haichao; Zhang, Yong; Zhang, Huimao; Chen, Zhiming

doi:10.1007/s00414-022-02909-8

Cited by 2 publications

(1 citation statement)

References 41 publications

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“…47 At this stage, the mechanism of damage had been altered, and although the medulla oblongata tissue could be considered an elastic solid, potential damage could still occur. 25 That is the reason that highfrequency impacts such as whiplash injuries 50 could still harm the medulla oblongata tissue. In contrast, at lower frequencies (<0.00001 Hz), the viscoelastic response of the medulla oblongata tissue was almost negligible, indicating an almost purely elastic response.…”

Section: Effect Of Pulsed Electric Fields On Time-dependent Behaviorsmentioning

confidence: 99%

Evaluating the Effects of Pulsed Electrical Stimulation on the Mechanical Behavior and Microstructure of Medulla Oblongata Tissues

Li,

Zong,

Zhao

et al. 2024

ACS Biomater. Sci. Eng.

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The development of remote surgery hinges on comprehending the mechanical properties of the tissue at the surgical site. Understanding the mechanical behavior of the medulla oblongata tissue is instrumental for precisely determining the remote surgery implementation site. Additionally, exploring this tissue’s response under electric fields can inform the creation of electrical stimulation therapy regimens. This could potentially reduce the extent of medulla oblongata tissue damage from mechanical compression. Various types of pulsed electric fields were integrated into a custom-built indentation device for this study. Experimental findings suggested that applying pulsed electric fields amplified the shear modulus of the medulla oblongata tissue. In the electric field, the elasticity and viscosity of the tissue increased. The most significant influence was noted from the low-frequency pulsed electric field, while the burst pulsed electric field had a minimal impact. At the microstructural scale, the application of an electric field led to the concentration of myelin in areas distant from the surface layer in the medulla oblongata, and the orderly structure of proteoglycans became disordered. The alterations observed in the myelin and proteoglycans under an electric field were considered to be the fundamental causes of the changes in the mechanical behavior of the medulla oblongata tissue. Moreover, cell polarization and extracellular matrix cavitation were observed, with transmission electron microscopy results pointing to laminar separation within the myelin at the ultrastructure scale. This study thoroughly explored the impact of electric field application on the mechanical behavior and microstructure of the medulla oblongata tissue, delving into the underlying mechanisms. This investigation delved into the changes and mechanisms in the mechanical behavior and microstructure of medulla oblongata tissue under the influence of electric fields. Furthermore, this study could serve as a reference for the development of electrical stimulation regimens in the central nervous system. The acquired mechanical behavior data could provide valuable baseline information to aid in the evolution of remote surgery techniques involving the medulla oblongata tissue.

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Section: Effect Of Pulsed Electric Fields On Time-dependent Behaviorsmentioning

confidence: 99%

Evaluating the Effects of Pulsed Electrical Stimulation on the Mechanical Behavior and Microstructure of Medulla Oblongata Tissues

Li,

Zong,

Zhao

et al. 2024

ACS Biomater. Sci. Eng.

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Stumpfe Gewalt in der forensischen Radiologie

Zech,

Ruder

2024

Radiologie

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Zusammenfassung Hintergrund Darstellung der wesentlichen forensisch-radiologischen Untersuchungsmodalitäten und Befunde bei stumpfer Gewalt bei lebenden und verstorbenen Erwachsenen. Methoden Herausarbeitung der wesentlichen Punkte anhand eigener praktischer Erfahrung der Autoren sowie einschlägiger Fachliteratur. Ergebnisse und Schlussfolgerung Verletzungsbedingte Folgen stumpfer Gewalt sind in der forensisch-radiologischen Diagnostik häufig zu beobachten, vor allem im Rahmen von Unfällen und Suiziden, seltener bei Tötungsdelikten. Die Methode der Wahl zur radiologischen Darstellung von stumpfer Gewalt bei Verstorbenen ist die native postmortale Computertomographie (PMCT). Grundsätzlich unterscheiden sich Folgen stumpfer Gewalt radiologisch in der PMCT nicht wesentlich vom Lebenden. Die postmortale Magnetresonanztomographie (PMMR) ist im kürzeren postmortalen Intervall sehr gut zur Darstellung von stumpfen Weichteilverletzungen geeignet. Bei Lebenden mit Folgen stumpfer Gewalt erfolgt die Indikation zur Bildgebung primär aus klinisch-diagnostischen Gründen. Häufige Indikationen sind häusliche Gewalt, Gewalt an älteren Personen sowie Auseinandersetzungen im öffentlichen Raum. Die Wahl der radiologischen Untersuchungsmethode ist abhängig von klinischer Anamnese und Symptomatik, wobei die radiologischen Untersuchungen einer forensischen Begutachtung unterzogen werden können.

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Application of postmortem MRI for identification of medulla oblongata contusion as a cause of death: a case report

Cited by 2 publications

References 41 publications

Evaluating the Effects of Pulsed Electrical Stimulation on the Mechanical Behavior and Microstructure of Medulla Oblongata Tissues

Evaluating the Effects of Pulsed Electrical Stimulation on the Mechanical Behavior and Microstructure of Medulla Oblongata Tissues

Stumpfe Gewalt in der forensischen Radiologie

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