Application of Polymeric Nano-Materials in Management of Inflammatory Bowel Disease

Abstract

Inflammatory Bowel Disease (IBD) is an umbrella term used to describe disorders that involve Crohn’s disease (CD), ulcerative colitis (UC) and pouchitis. The disease occurrence is more prevalent in the working group population which not only hampers the well being of an individual but also has negative economical impact on society. The current drug regime used therapy is very costly owing to the chronic nature of the disease leading to several side effects. The condition gets more aggravated due to the lower concentration of drug at the desired site. Therefore, in the present scenario, a therapy is needed which can maximize efficacy, adhere to quality of life, minimize toxicity and doses, be helpful in maintaining and stimulating physical growth of mucosa with minimum disease complications. In this aspect, nanotechnology intervention is one promising field as it can act as a carrier to reduce toxicity, doses and frequency which in turn help in faster recovery. Moreover, nanomedicine and nanodiagnostic techniques will further open a new window for treatment in understanding pathogenesis along with better diagnosis which is poorly understood till now. Therefore the present review is more focused on recent advancements in IBD in the application of nanotechnology.

Therapeutic effect of biosynthetic gold nanoparticles on multidrug-resistant Escherichia coli and Salmonella species isolated from ruminants

“…Most of the β-lactam resistance in Salmonella is provided by horizontally acquired β-lactamases. However, many other bacteria have intrinsic ampC, bla TEM , bla CTX-M , bla IMP , bla VIM , bla KPC , bla SHV , and bla OXA [10]. MDR strains such as Salmonella spp.…”

Current Strategies and Potential Prospects of Nanomedicine-Mediated Therapy in Inflammatory Bowel Disease

“…80 A controlled-release system, in such cases, provides an ideal strategy to maintain the frequency and concentration of drug release. 73,[81][82][83] For instance, high-water content hydrogel, a copolymer with a cross-linked network, has high biocompatibility with its physical similarity to biological tissues. 84 Hydrogels are proven effective in loading hydrophilic drugs and protecting them from being desaturated or aggregated.…”

Nanotechnology in Colorectal Cancer for Precision Diagnosis and Therapy

“…Nanotechnology has opened up a new way to the development of novel and efficiently organized nanomaterials with the capability of enhanced performance in screening, detection, and treatment of CRC cancer along with other types of tumors (Gulbake et al, 2016;Bray et al, 2019). The role of nanotechnology interventions to CRC includes the nanomaterialbased screening of tumors, customization of targeted drug delivery systems, and advanced treatment modalities (Upendra et al, 2016;Minakshi et al, 2017;Minakshi et al, 2018;Minakshi et al, 2020). Currently, nanotechnologies have found worldwide consideration due to their capability to improve existing standards and methods for the screening, diagnosis, and treatment of CRC.…”