Application of polyionic magnetic nanoparticles as a catalyst for the synthesis of carbonitriles with both indole and triazole moieties via a cooperative geminal-vinylogous anomeric-based oxidation

Chemistry of 3-cyanoacetyl indoles: synthesis, reactions and applications: a recent update

“…In 2022, Baghery and his group developed three-component reaction of aromatic aldehydes with 3-(1 H -indol-3-yl)-3-oxopropanenitrile (1a) and 1 H -1,2,4-triazol-5-amine under the solvent-free condition at 70 °C in the presence of polyionic magnetic nanoparticles with pyrazine bridge [Fe 3 O 4 @SiO 2 @(CH 2 ) 3 ] 2 -pyrazinium-[TCM] 2 as a catalyst for the synthesis of 7-aryl-5-(1 H -indol-3-yl)-[1,2,4]triazolo[1,5- a ]pyrimidine-6-carbonitriles 122 in 89–95% yields via a cooperative anomeric-based oxidation ( Scheme 47 ). 81 …”

Synthesis of pyrimidine-6-carbonitriles, pyrimidin-5-ones, and tetrahydroquinoline-3-carbonitriles by new superb oxovanadium(V)-[5,10,15,20-tetrakis(pyridinium)-porphyrinato]-tetra(tricyanomethanide) catalyst via anomeric based oxidation

“…To continue our investigations in this field [65][66][67][68][69][70] , herein, we synthesized numerous pyrimidine-6-carbonitrile, pyrimidin-5-one, and tetrahydroquinoline-3-carbonitrile compounds via a cooperative geminal-vinylogous anomeric based oxidation under solvent-free conditions at 100 °C (Fig. 2) by using oxovanadium(V)-[5,10,15,20tetrakis(pyridinium)-porphyrinato]-tetra(tricyanomethanide) [(VO)TPP][(TCM) 4 ] as a versatile catalyst (Fig.…”

Synthesis, Anti-mycobacterial activity, Molecular Docking and ADME analysis of spiroquinoxaline-1,2,4-oxadiazoles via [3+2] cycloaddition reaction under ultrasound irradiation

“…The utilization of mechanical and thermal energy for chemical reactions is enabled by the acoustic cavitation produced by ultrasonication without signi cantly modifying the reaction medium. The energy created by the cavity effect accelerates processes and reduces reaction time at room temperature by increasing solubility, mass transfer, and diffusivity [25][26][27]. There is no literature on the synthesis of spiroquinoxaline-1,2,4oxadiazoles utilizing ultrasonic irradiation that we are aware of now.…”