Application of PLASMIC score in prediction of ADAMTS13 deficiency in a pediatric case of acquired thrombotic thrombocytopenic purpura

Gupta, Gaurav; Hendrickson, Jeanne E.; Tormey, Christopher A.

doi:10.1002/jca.21767

Cited by 5 publications

(2 citation statements)

References 9 publications

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“…The PLASMIC score discriminates between PTT and other TMA, such as atypical uremic syndrome, reliably assesses the likelihood of a severe deficit of ADAMTS13 activity in patients with TMA and could help improve the accuracy of clinical assessment and be beneficial when ADAMTS13 testing is unavailable 12,13 . Gupta et al reported that the PLASMIC score could also be a good predictor to identify pediatric patients with an ADAMTS13 activity less than 10% 14 .…”

Section: Discussionmentioning

confidence: 99%

Thrombotic thrombocytopenic purpura associated with COVID-19 in a critically ill child: a Peruvian case report

Domínguez-Rojas¹,

Campano²,

Tasayco³

et al. 2022

BMHIM

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Background: Acquired thrombotic thrombocytopenic purpura (TTP) is a rare disease. In middle and low-income countries, specific resources are required for its diagnosis due to the lack of diagnostic tests and the variable response to plasma exchange, especially in the context of the new SARS-CoV-2 pandemic. Case report: We report the case of a 9-year-old male Hispanic patient with SARS-CoV-2 infection, atypical presentation, and multisystem involvement, thrombotic microangiopathy with dermal manifestations, hematologic, renal, and neurologic involvement. The patient was followed up after SARS-CoV-2 infection, the PLASMIC score was applied, and a genetic study was performed. Ventilation and hemodynamic support, corticotherapy, immunoglobulins, plasma exchange, renal replacement therapy, and monoclonal antibodies were given without favorable response. Conclusions: TTP associated with SARS-CoV-2 in the pediatric population is rare. However, resources for the diagnosis, support, and management of patients with TTP are required to avoid fatal outcomes.

show abstract

Section: Discussionmentioning

confidence: 99%

Thrombotic thrombocytopenic purpura associated with COVID-19 in a critically ill child: a Peruvian case report

Domínguez-Rojas¹,

Campano²,

Tasayco³

et al. 2022

BMHIM

View full text Add to dashboard Cite

show abstract

“…The PLASMIC Score discriminated between PTT and other MAT, such as atypical uremic syndrome, reliably assesses the likelihood of a severe de cit of ADAMTS13 activity in patients with MAT and could help improve the accuracy of clinical assessment and be bene cial when ADAMTS13 testing is not available (11,12). Gupta et al report that PLASMIC score could also be a good predictor in children to identify patients with an ADAMTS13 activity less than 10% (13).…”

Section: Discussionmentioning

confidence: 99%

Thrombotic thrombocytopenic purpura associated with COVID-19 in a critically ill child: A Peruvian case report

Domínguez-Rojas

Campano

Tasayco

et al. 2021

Preprint

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Background Acquired thrombotic thrombocytopenic purpura (TTP) is a rare disease. This pathology requires necessary resources for its diagnosis, especially in the context of the pandemic by the new SARS-CoV-2 coronavirus due to the lack of diagnostic tests and the variable response to plasma exchange in middle and low-income countries. Case report: We report a case of a 9-year-old Hispanic boy with SARS-CoV-2 (IgG) infection, with atypical presentation and multisystemic involvement, thrombotic microangiopathy, dermal manifestations, hematologic, kidney, and neurologic involvement. Post SARS-CoV-2 infection evolution, application of the PLASMIC score, and genetic study were performed. Ventilatory and hemodynamic support, corticotherapy, immunoglobulins, plasma exchange, renal replacement therapy, and monoclonal antibodies were given without favorable response. Conclusions TTP associated with SARS-CoV-2 is infrequent in the pediatric population. Necessary resources are needed to make the diagnosis and maintain the necessary support and management to avoid fatal outcomes.

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Thrombotic Thrombocytopenic Purpura, Atypical Hemolytic Uremic Syndrome, and Spectrum of Thrombotic Microangiopathy

Khursigara

Benoit

Patriquin

et al. 2022

Pediatric Nephrology

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Application of PLASMIC score in prediction of ADAMTS13 deficiency in a pediatric case of acquired thrombotic thrombocytopenic purpura

Cited by 5 publications

References 9 publications

Thrombotic thrombocytopenic purpura associated with COVID-19 in a critically ill child: a Peruvian case report

Thrombotic thrombocytopenic purpura associated with COVID-19 in a critically ill child: a Peruvian case report

Thrombotic thrombocytopenic purpura associated with COVID-19 in a critically ill child: A Peruvian case report

Thrombotic Thrombocytopenic Purpura, Atypical Hemolytic Uremic Syndrome, and Spectrum of Thrombotic Microangiopathy

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