Application of P/VB staining to identify antemortem injury in a decomposed cadaver

Sun, Tianying; Pan, Meichen; Zhu, Weiwei; Liu, Huine; Yang, Chenguang; Dong, Hongmei

doi:10.1007/s12024-022-00533-x

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…Skin is a good biological sample in 2 of 21 cadavers, capable of detecting DNA typing with specific stains of nucleus chromatin (Lillie's staining) even in leathery and mummified skin samples [3]. Sun et al [4] utilized the P/VB-specific staining of collagen and muscle near the scalp in a decomposed cadaver, and confirmed the fatal antemortem wound of the decedent. However, the histological methods may not address various conditions in an advanced decomposed cadaver.…”

Section: Introductionmentioning

confidence: 99%

The Role of Protein Degradation in Estimation Postmortem Interval and Confirmation of Cause of Death in Forensic Pathology: A Literature Review

Huang,

Zhao,

Liu

et al. 2024

IJMS

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It is well known that proteins are important bio-macromolecules in human organisms, and numerous proteins are widely used in the clinical practice, whereas their application in forensic science is currently limited. This limitation is mainly attributed to the postmortem degradation of targeted proteins, which can significantly impact final conclusions. In the last decade, numerous methods have been established to detect the protein from a forensic perspective, and some of the postmortem proteins have been applied in forensic practice. To better understand the emerging issues and challenges in postmortem proteins, we have reviewed the current application of protein technologies at postmortem in forensic practice. Meanwhile, we discuss the application of proteins in identifying the cause of death, and postmortem interval (PMI). Finally, we highlight the interpretability and limitations of postmortem protein challenges. We believe that utilizing the multi-omics method can enhance the comprehensiveness of applying proteins in forensic practice.

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Section: Introductionmentioning

confidence: 99%

The Role of Protein Degradation in Estimation Postmortem Interval and Confirmation of Cause of Death in Forensic Pathology: A Literature Review

Huang,

Zhao,

Liu

et al. 2024

IJMS

Self Cite

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Conventional HE staining combined with two special staining methods to identify antemortem stab wound in case with highly decomposed mutilated corpses

Chen

Zhu

et al. 2023

Forensic Sci Med Pathol

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Use of various research methods in forensic practice to determine lifetime and age of injury: A review

Frolova,

Zabozlaev,

Klevno

2023

Russian Journal of Forensic Medicine

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The problem of the prescription of damage formation has been of interest to forensic physicians since the XIX century to the present. After analyzing the literature sources on the problem of the prescription of traumatic hemorrhages, it becomes clear that there is no single position, approach to the study of this issue, an unambiguous time frame that accurately determines the period from injury to the moment of death of the victim. Both in the nineteenth century and in the twenty-first, forensic doctors initially focused on the macroscopic picture of the injury followed by microscopic examination. When studying micropreparations, they are guided by: the cellular composition of hemorrhage, based on already known data, on their own experience and knowledge in this matter, on the brief circumstances of the incident (if any are indicated in the direction of forensic histological examination), on the age of the victim. Over the years, with the acquired experience and accumulated knowledge, researchers have determined approximate, developed approximate time frames for the formation of damage, now taking into account not only the above parameters, but also the condition of the victim during and after the injury. But scientists have not come to a consensus. Medicine, achievements, progress and perseverance of scientists strive forward, involving related sciences in the study of antiquity. As a result, such methods as: molecular genetic, biophysical, biochemical, immunohistochemical, etc., have found their application, allowing to study not only the cellular composition, but also enzymatic, hormonal changes in damaged tissues. Instrumental methods are being developed: ultrasound. When using both laboratory and instrumental methods, as well as their combination, this problem remains completely unresolved.

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Application of P/VB staining to identify antemortem injury in a decomposed cadaver

Cited by 3 publications

References 6 publications

The Role of Protein Degradation in Estimation Postmortem Interval and Confirmation of Cause of Death in Forensic Pathology: A Literature Review

The Role of Protein Degradation in Estimation Postmortem Interval and Confirmation of Cause of Death in Forensic Pathology: A Literature Review

Conventional HE staining combined with two special staining methods to identify antemortem stab wound in case with highly decomposed mutilated corpses

Use of various research methods in forensic practice to determine lifetime and age of injury: A review

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