Application of oxygen vacancy defects in enhanced anti-cancer nanomedicine

Gao, Yuan; Liu, Shuangqing; Liu, Hui; Ge, Haiyan; Zhang, Meng; Zhao, Chunyu; Gong, Yufang; Zhang, Xinyu; Wang, Chao; Sun, Xiao; Wu, Zhengyan

doi:10.1007/s11426-023-1693-8

Cited by 6 publications

(2 citation statements)

References 150 publications

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“…At the same time, defects can induce new discrete bands below the conduction band (CB), thus promoting surface charge transfer and playing a catalytic role. [45] For example, in our previous work, [46] electrical conductivity and N 2 adsorption capacity. The O V -Bi 2 MoO 6 nanosheets obtained a good NH 3 yield of 24.38 μg•mg À 1 •h À 1 in À 0.3 V hydrochloric acid solution with a Faraday efficiency of 14.1 %.…”

Section: Introductionmentioning

confidence: 99%

Defect Engineering in Bi‐Based Photo/Electrocatalysts for Nitrogen Reduction to Ammonia

Lv,

Wang,

Wang

et al. 2024

Chemistry A European J

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Main group Bi‐based materials have gained popularity as N2 reduction reaction (NRR) photo/electrocatalysts due to their ability to inhibit competitive H2 evolution reactions (HER) and the unique N2 adsorption activities. The introduction of defects in Bi‐based catalysts represents a highly effective strategy for enhancing light absorption, promoting efficient separation of photogenerated carriers, optimizing the activity of free radicals, regulating electronic structure, and improving catalytic performance. In this review, we outline the various applications of state of the defect engineering in Bi‐based catalysts and elucidate the impact of vacancies on NRR performance. In particular, the types of defects, methods of defects tailoring, advanced characterization techniques, as well as the Bi‐based catalysts with abundant defects and their corresponding catalytic behavior in NRR were elucidated in detail. Finally, the main challenges and opportunities for future development of defective Bi‐based NRR catalysts are discussed, which provides a comprehensive theoretical guidance for this field.

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Section: Introductionmentioning

confidence: 99%

Defect Engineering in Bi‐Based Photo/Electrocatalysts for Nitrogen Reduction to Ammonia

Lv,

Wang,

Wang

et al. 2024

Chemistry A European J

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“…Increasing evidence showed the heterogeneity of the tumor microenvironment and its important role in promoting tumor occurrence and treatment resistance [ 21 ]. In addition, Single-cell transcriptomics reveals intricate intercellular communication networks within diverse cell types in the TME [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Integrative analyses of bulk and single-cell transcriptomics reveals the infiltration and crosstalk of cancer-associated fibroblasts as a novel predictor for prognosis and microenvironment remodeling in intrahepatic cholangiocarcinoma

Zhong,

Luo,

Liu

et al. 2024

J Transl Med

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Background Intrahepatic cholangiocarcinoma (ICC) is a highly malignant neoplasm and characterized by desmoplastic matrix. The heterogeneity and crosstalk of tumor microenvironment remain incompletely understood. Methods To address this gap, we performed Weighted Gene Co-expression Network Analysis (WGCNA) to identify and construct a cancer associated fibroblasts (CAFs) infiltration biomarker. We also depicted the intercellular communication network and important receptor-ligand complexes using the single-cell transcriptomics analysis of tumor and Adjacent normal tissue. Results Through the intersection of TCGA DEGs and WGCNA module genes, 784 differential genes related to CAFs infiltration were obtained. After a series of regression analyses, the CAFs score was generated by integrating the expressions of EVA1A, APBA2, LRRTM4, GOLGA8M, BPIFB2, and their corresponding coefficients. In the TCGA-CHOL, GSE89748, and 107,943 cohorts, the high CAFs score group showed unfavorable survival prognosis (p < 0.001, p = 0.0074, p = 0.028, respectively). Additionally, a series of drugs have been predicted to be more sensitive to the high-risk group (p < 0.05). Subsequent to dimension reduction and clustering, thirteen clusters were identified to construct the single-cell atlas. Cell-cell interaction analysis unveiled significant enhancement of signal transduction in tumor tissues, particularly from fibroblasts to malignant cells via diverse pathways. Moreover, SCENIC analysis indicated that HOXA5, WT1, and LHX2 are fibroblast specific motifs. Conclusions This study reveals the key role of fibroblasts - oncocytes interaction in the remodeling of the immunosuppressive microenvironment in intrahepatic cholangiocarcinoma. Subsequently, it may trigger cascade activation of downstream signaling pathways such as PI3K-AKT and Notch in tumor, thus initiating tumorigenesis. Targeted drugs aimed at disrupting fibroblasts-tumor cell interaction, along with associated enrichment pathways, show potential in mitigating the immunosuppressive microenvironment that facilitates tumor progression.

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Calcium ascorbate loaded ultrathin ferrous sulfide nanosheets thermo-sensitive hydrogels for near-infrared light activation of synergistic endometriosis therapy

Wang,

Tian,

Dai

et al. 2024

Chemical Engineering Journal

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Application of oxygen vacancy defects in enhanced anti-cancer nanomedicine

Cited by 6 publications

References 150 publications

Defect Engineering in Bi‐Based Photo/Electrocatalysts for Nitrogen Reduction to Ammonia

Defect Engineering in Bi‐Based Photo/Electrocatalysts for Nitrogen Reduction to Ammonia

Integrative analyses of bulk and single-cell transcriptomics reveals the infiltration and crosstalk of cancer-associated fibroblasts as a novel predictor for prognosis and microenvironment remodeling in intrahepatic cholangiocarcinoma

Calcium ascorbate loaded ultrathin ferrous sulfide nanosheets thermo-sensitive hydrogels for near-infrared light activation of synergistic endometriosis therapy

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