Application of Oxidative Coupling Reaction using Brucine and Sodium Periodate as Chromogenic Reagent for the Assay of Perindopril Erbumine in Formulations
Abstract:The drug Perindopril Erbumine (PE), an ACE inhibitor, and can be used to treat the patients with hypertension and cardiac failure problems. A sensitive, inexpensive, and precise analytical technique has been developed for the estimation of Perindopril in bulk and formulations. The procedure involves the development of color by forming an oxidative coupling reaction between drug (PE) and Brucine/IO4 -). The formed colored species were measured at max=520 nm. The developed method showed linearity within the con… Show more
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