Application of over-sampling nano-sensitive optical coherence tomography for monitoring corneal internal structural changes in corneal cross-linking

Zhou, Yi; Alexandrov, Sergey; Nolan, Andrew; Dey, Rajib; Das, Nandan; Neuhaus, Kai; Leahy, Martin J.

doi:10.1117/12.2547317

Cited by 1 publication

(1 citation statement)

References 11 publications

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“…The depth resolution of an OCT system is defined by the source coherence length, with typical values of 6–15 µm in air, and the lateral resolution by probe beam size diameter. Nano-sensitive OCT is a modern design that provides extra sensitivity to nanometer-scale structural changes or measurements [ 12 , 13 , 14 , 15 , 16 , 17 ]. Though depicting cellular or sub-cellular level structures remains a challenge, the imaging resolution of OCT is still at least 20 times finer than other in vivo 3D imaging techniques, such as ultrasound.…”

Section: Conventional Octmentioning

confidence: 99%

Molecular Contrast Optical Coherence Tomography and Its Applications in Medicine

Wang

Gao

et al. 2022

IJMS

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The growing need to understand the molecular mechanisms of diseases has prompted the revolution in molecular imaging techniques along with nanomedicine development. Conventional optical coherence tomography (OCT) is a low-cost in vivo imaging modality that provides unique high spatial and temporal resolution anatomic images but little molecular information. However, given the widespread adoption of OCT in research and clinical practice, its robust molecular imaging extensions are strongly desired to combine with anatomical images. A range of relevant approaches has been reported already. In this article, we review the recent advances of molecular contrast OCT imaging techniques, the corresponding contrast agents, especially the nanoparticle-based ones, and their applications. We also summarize the properties, design criteria, merit, and demerit of those contrast agents. In the end, the prospects and challenges for further research and development in this field are outlined.

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