Application of nutrigenomics in small ruminants: Lactation, growth, and beyond

Osorio, J. S.; Vailati-Riboni, Mario; Palladino, Alejandro; Luo, Jun; Loor, Juan J.

doi:10.1016/j.smallrumres.2017.06.021

Cited by 21 publications

(22 citation statements)

References 184 publications

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“…On the other hand, several genes that are involved in the regulation of lipid metabolism and the signalling pathways that regulate expression of those genes have been identified in humans and animals in recent years . However, further studies would allow a better understanding of the regulation of ruminant lipid metabolism at a molecular level …”

Section: Resultsmentioning

confidence: 99%

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Quick changes of milk fatty acids after inclusion or suppression of linseed oil in the diet of goats

et al. 2018

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Section: Resultsmentioning

confidence: 99%

“…[35][36][37] However, further studies would allow a better understanding of the regulation of ruminant lipid metabolism at a molecular level. 38…”

Section: Polyunsaturated Fatty Acidsmentioning

confidence: 99%

Quick changes of milk fatty acids after inclusion or suppression of linseed oil in the diet of goats

et al. 2018

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“…The latter can form homodimers and be activated in the presence of the retinoid 9-cis-retinoic acid and consequently activating specific target genes [23]. From the two isoforms (i.e., α and β) of RXR, the RXRα has been the most evaluated in ruminants, primarily because it can form heterodimers with most LdNR including PPAR, LXR, and VDR [24]. Although the latter confers RXRα a tremendous biological significance, there are limited data in ruminants on the potential nutrigenomic effects of vitamin A and derivative retinoids such as 9-cis-retinoic acid through RXRα.…”

Section: Mediators Of Nutrient-gene Interactions In Ruminantsmentioning

confidence: 99%

“…From this superfamily, a short list of TFs has been identified as ligand-dependent nuclear receptors (LdNR), which can bind and be activated by macro-and micronutrients [55]. Recently, the main LdNR with a potential role in nutrigenomics with an emphasis in large [62] and small [24] ruminants has been reviewed. Among the LdNR associated with macronutrients such as fatty acids are the peroxisome proliferator-activated receptors (PPAR), liver X receptors (LXR), and hepatic nuclear factor 4 (HNF4) [63].…”

Section: Transcription Factors With Nutrigenomic Potential In Dairy Cmentioning

confidence: 99%

Gene Regulation in Ruminants: A Nutritional Perspective

Osorio¹,

Moisá²

2019

Gene Expression and Control

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This chapter will focus on cellular regulatory programs implemented by the ruminant physiology in order to respond to external stimuli such as nutrition as well as important physiological events such as parturition. The increasing adoption of "omics" technologies and bioinformatics in nutrition and physiology in ruminant research have allowed us to delineate a clearer picture on what regulates major biological process at a molecular level such as milk synthesis and meat quality and fatty acid composition as well as pathological conditions such as ketosis, mastitis, and heat stress. The assembly of such plethora of information in a blend among nutritional research, molecular biology, and novel tools to study the response of the genome to nutrition has led to emerging disciplines such as nutritional genomics or "nutrigenomics."

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“…Cattle, goat, and sheep have been widely used for years as models to study ruminal fermentation and the mechanisms whereby tissues use nutrients for milk synthesis, growth, and reproduction. 1 For the dairy cow, feeding in the dry period strongly influences the metabolic process, feed intake after calving, fertility, as well as milk production and composition. The transition from late gestation to early lactation also represents a challenge for high-yielding dairy cows.…”

Section: Introductionmentioning

confidence: 99%

Transcriptomic Impacts of Rumen Epithelium Induced by Butyrate Infusion in Dairy Cattle in Dry Period

Baldwin

Jia

et al. 2018

Gene�Regul Syst Bio

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The purpose of this study was to evaluate the effects of butyrate infusion on rumen epithelial transcriptome. Next-generation sequencing (NGS) and bioinformatics are used to accelerate our understanding of regulation in rumen epithelial transcriptome of cattle in the dry period induced by butyrate infusion at the level of the whole transcriptome. Butyrate, as an essential element of nutrients, is a histone deacetylase (HDAC) inhibitor that can alter histone acetylation and methylation, and plays a prominent role in regulating genomic activities influencing rumen nutrition utilization and function. Ruminal infusion of butyrate was following 0-hour sampling (baseline controls) and continued for 168 hours at a rate of 5.0 L/day of a 2.5 M solution as a continuous infusion. Following the 168-hour infusion, the infusion was stopped, and cows were maintained on the basal lactation ration for an additional 168 hours for sampling. Rumen epithelial samples were serially collected via biopsy through rumen fistulae at 0-, 24-, 72-, and 168-hour (D1, D3, D7) and 168-hour post-infusion (D14). In comparison with pre-infusion at 0 hours, a total of 3513 genes were identified to be impacted in the rumen epithelium by butyrate infusion at least once at different sampling time points at a stringent cutoff of false discovery rate (FDR) < 0.01. The maximal effect of butyrate was observed at day 7. Among these impacted genes, 117 genes were responsive consistently from day 1 to day 14, and another 42 genes were lasting through day 7. Temporal effects induced by butyrate infusion indicate that the transcriptomic alterations are very dynamic. Gene ontology (GO) enrichment analysis revealed that in the early stage of rumen butyrate infusion (on day 1 and day 3 of butyrate infusion), the transcriptomic effects in the rumen epithelium were involved with mitotic cell cycle process, cell cycle process, and regulation of cell cycle. Bioinformatic analysis of cellular functions, canonical pathways, and upstream regulator of impacted genes underlie the potential mechanisms of butyrate-induced gene expression regulation in rumen epithelium. The introduction of transcriptomic and bioinformatic technologies to study nutrigenomics in the farm animal presented a new prospect to study multiple levels of biological information to better apprehend the whole animal response to nutrition, physiological state, and their interactions. The nutrigenomics approach may eventually lead to more precise management of utilization of feed resources in a more effective approach.

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Application of nutrigenomics in small ruminants: Lactation, growth, and beyond

Cited by 21 publications

References 184 publications

Quick changes of milk fatty acids after inclusion or suppression of linseed oil in the diet of goats

Quick changes of milk fatty acids after inclusion or suppression of linseed oil in the diet of goats

Gene Regulation in Ruminants: A Nutritional Perspective

Transcriptomic Impacts of Rumen Epithelium Induced by Butyrate Infusion in Dairy Cattle in Dry Period

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