Application of Novel Quantitative Proteomic Technologies to Identify New Serological Biomarkers in Autoimmune Diseases

Lee, So‐Young; Serada, Satoshi; Fujimoto, Minoru; Naka, Tetsuji

doi:10.5772/20726

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Biomarker Discovery In Autoimmune Diseases1

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2012

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“…Diverse proteomic technologies have contributed to the discovery of biomarkers in autoimmune diseases, such as: ( i ) 2-DE and MS for auto-antigen discovery; ( ii ) autoantigen microarrays to typify autoantibody responses; ( iii ) antibody array technologies to profile cytokines and other biomolecules; ( iv ) reverse-phase protein arrays to analyze phosphoproteins; ( v ) flow cytometric analysis of phosphoproteins [ 57 , 60 ].…”

Section: Biomarker Discovery In Autoimmune Diseasesmentioning

confidence: 99%

Biomarker Discovery by Novel Sensors Based on Nanoproteomics Approaches

Dasilva

Díez

Matarraz

et al. 2012

Sensors

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During the last years, proteomics has facilitated biomarker discovery by coupling high-throughput techniques with novel nanosensors. In the present review, we focus on the study of label-based and label-free detection systems, as well as nanotechnology approaches, indicating their advantages and applications in biomarker discovery. In addition, several disease biomarkers are shown in order to display the clinical importance of the improvement of sensitivity and selectivity by using nanoproteomics approaches as novel sensors.

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Section: Biomarker Discovery In Autoimmune Diseasesmentioning

confidence: 99%