Application of Novel Drugs for Corneal Cell Regeneration

Han, Sang Beom; Liu, Yu-Chi; Mohamed-Noriega, Karim

doi:10.1155/2018/1215868

Cited by 10 publications

(8 citation statements)

References 106 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rho-kinase (ROCK) inhibitor is a serine/threonine protein kinase that participates in regulating cell signaling pathway. Recently ROCK has been introduced as an innovative therapeutic agent for corneal endothelial dystrophy (Han et al, 2018). The compilation of these approaches can be a promising method for visual rehabilitation in patients suffering from corneal dystrophies.…”

Section: Conclusion and Future Outlookmentioning

confidence: 99%

Corneal Repair and Regeneration: Current Concepts and Future Directions

Mobaraki

Abbasi

Vandchali

et al. 2019

Front. Bioeng. Biotechnol.

117

109

View full text Add to dashboard Cite

The cornea is a unique tissue and the most powerful focusing element of the eye, known as a window to the eye. Infectious or non-infectious diseases might cause severe visual impairments that need medical intervention to restore patients' vision. The most prominent characteristics of the cornea are its mechanical strength and transparency, which are indeed the most important criteria considerations when reconstructing the injured cornea. Corneal strength comes from about 200 collagen lamellae which criss-cross the cornea in different directions and comprise nearly 90% of the thickness of the cornea. Regarding corneal transparency, the specific characteristics of the cornea include its immune and angiogenic privilege besides its limbus zone. On the other hand, angiogenic privilege involves several active cascades in which anti-angiogenic factors are produced to compensate for the enhanced production of proangiogenic factors after wound healing. Limbus of the cornea forms a border between the corneal and conjunctival epithelium, and its limbal stem cells (LSCs) are essential in maintenance and repair of the adult cornea through its support of corneal epithelial tissue repair and regeneration. As a result, the main factors which threaten the corneal clarity are inflammatory reactions, neovascularization, and limbal deficiency. In fact, the influx of inflammatory cells causes scar formation and destruction of the limbus zone. Current studies about wound healing treatment focus on corneal characteristics such as the immune response, angiogenesis, and cell signaling. In this review, studied topics related to wound healing and new approaches in cornea regeneration, which are mostly related to the criteria mentioned above, will be discussed.

show abstract

Section: Conclusion and Future Outlookmentioning

confidence: 99%

Corneal Repair and Regeneration: Current Concepts and Future Directions

Mobaraki

Abbasi

Vandchali

et al. 2019

Front. Bioeng. Biotechnol.

117

109

View full text Add to dashboard Cite

show abstract

“…NGF eye drops have become a promising therapeutic modality for the treatment of NK. Clinically, it promotes corneal epithelial healing, improves tear function and stimulates corneal nerves regeneration [111]. Several studies have established the safety and efficacy of NGF eye drops in the management of NK [112][113][114].…”

Section: Nerve Growth Factor (Ngf) Eye Dropsmentioning

confidence: 99%

Diabetic Corneal Neuropathy

Mansoor¹,

Tan

Lin

et al. 2020

JCM

Self Cite

View full text Add to dashboard Cite

Diabetic keratopathy (DK) is a common, but underdiagnosed, ocular complication of diabetes mellitus (DM) that has a significant economic burden. It is characterised by progressive damage of corneal nerves, due to DM-induced chronic hyperglycaemia and its associated metabolic changes. With advances in corneal nerve imaging and quantitative analytic tools, studies have shown that the severity of diabetic corneal neuropathy correlates with the status of diabetic peripheral neuropathy. The corneal nerve plexus is, therefore, considered as an important surrogate marker of diabetic peripheral neuropathy and helps in the evaluation of interventional efficacy in the management of DM. The clinical manifestations of DK depend on the disease severity and vary from decreased corneal sensitivity to sight-threatening corneal infections and neurotrophic ulcers. The severity of diabetic corneal neuropathy and resultant DK determines its management plan, and a step-wise approach is generally suggested. Future work would focus on the exploration of biomarkers for diabetic corneal neuropathy, the development of new treatment for corneal nerve protection, and the improvement in the clinical assessment, as well as current imaging technique and analysis, to help clinicians detect diabetic corneal neuropathy earlier and monitor the sub-clinical progression more reliably.

show abstract

“…Even in absence of adverse events, their application remains limited to the treatment of dry eye-related symptoms. Promising new strategies have been suggested for a wider approach to the anterior segment pathologies, addressing, for example, neurotrophic keratitis, persistent epithelial defects, diabetic keratopathy, and diabetic neuropathy, such as the use of topical insulin, naltrexone, ARIs, substance P, and different growth factors [160,169,170,174,200]. Poly-ε-lysine [190] Antifungals CL Silicone hydrogel (N/A) [191,194] Poly-ε-lysine [193] HEMA-PC [194] HEMA-MAA [194] HEMA-MAA-PVP [189,194] Sil-DMA-HEMA-PVP [194] Quaternized chitosan + graphene oxide [192] Antivirals CL HEMA-MAA [195,196] Collagen photosensitizer Riboflavin CL HEMA-PVP [197,199,201] Sil-DMA [201] PVP-MMA [201] Opioid antagonist Naltrexone CL HEMA [87] [44,45] Naltrexone (NTX) is an opioid antagonist, whose systemic or topical administration proved to block the negative effect of opioid growth factors, which are excessively present in diabetic patients, on cell proliferation and tissue growth.…”

Section: Corneal Diseasesmentioning

confidence: 99%

Section: Lenses For Ocular Diseasesmentioning

confidence: 99%

Therapeutic Ophthalmic Lenses: A Review

2020

View full text Add to dashboard Cite

An increasing incidence of eye diseases has been registered in the last decades in developed countries due to the ageing of population, changes in lifestyle, environmental factors, and the presence of concomitant medical conditions. The increase of public awareness on ocular conditions leads to an early diagnosis and treatment, as well as an increased demand for more effective and minimally invasive solutions for the treatment of both the anterior and posterior segments of the eye. Despite being the most common route of ophthalmic drug administration, eye drops are associated with compliance issues, drug wastage by lacrimation, and low bioavailability due to the ocular barriers. In order to overcome these problems, the design of drug-eluting ophthalmic lenses constitutes a non-invasive and patient-friendly approach for the sustained drug delivery to the eye. Several examples of therapeutic contact lenses and intraocular lenses have been developed, by means of different strategies of drug loading, leading to promising results. This review aims to report the recent advances in the development of therapeutic ophthalmic lenses for the treatment and/or prophylaxis of eye pathologies (i.e., glaucoma, cataract, corneal diseases, or posterior segment diseases) and it gives an overview of the future perspectives and challenges in the field.

show abstract

Application of Novel Drugs for Corneal Cell Regeneration

Cited by 10 publications

References 106 publications

Corneal Repair and Regeneration: Current Concepts and Future Directions

Corneal Repair and Regeneration: Current Concepts and Future Directions

Diabetic Corneal Neuropathy

Therapeutic Ophthalmic Lenses: A Review

Contact Info

Product

Resources

About