Application of NGS Technology in Understanding the Pathology of Autoimmune Diseases

Wajda, Anna; Sivitskaya, L. N.; Paradowska‐Gorycka, Agnieszka

doi:10.3390/jcm10153334

Cited by 3 publications

(1 citation statement)

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“…Next-generation sequencing technology has shown to be useful in pathogen recognition and may also have an important role in diagnosing autoimmune conditions [ 15 ]. Possible applications include microRNA (miRNA) expression patterns and HLA gene polymorphisms [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Polyarteritis Nodosa Following mRNA-1273 COVID-19 Vaccination: Case Study and Review of Immunological Mechanisms

Srichawla¹

2023

Cureus

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Numerous post-vaccine complications have been reported secondary to the COVID-19 vaccine. Many of these complications are believed to be due to a hyperactive immune system. A 59-year-old woman developed diffuse abdominal pain two days after receiving the mRNA-1273 COVID-19 vaccine (Moderna). A computerized tomography (CT) angiogram of the abdomen and pelvis revealed the presence of numerous vascular irregularities in the celiac axis, bilateral renal arteries, and inferior mesenteric artery consistent with polyarteritis nodosa (PAN), a medium-vessel vasculitis. The patient was managed with intravenous methylprednisolone 500 mg daily for three days and was then placed on oral methotrexate (MTX) 12.5 mg daily for immunosuppressive maintenance treatment. Until now, a limited number of cases of polyarteritis nodosa secondary to the COVID-19 vaccine have been reported. Major mechanisms of post-vaccine autoimmunity are molecular mimicry and autoantibody production. Although rare adverse events from COVID-19 vaccination are possible, there remains an immense benefit to vaccination in preventing COVID-19-related morbidity and mortality.

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Section: Discussionmentioning

confidence: 99%