Application of neutron capture autoradiography to Boron Delivery seeking techniques for selective accumulation of boron compounds to tumor with intra-arterial administration of boron entrapped water-in-oil-in-water emulsion

Selective boron delivery by intra-arterial injection of BSH-WOW emulsion in hepatic cancer model for neutron capture therapy

“…The set of liver samples were simultaneously exposed in the JRR3 reactor of the Japan Atomic Energy Research Institute with an average thermal neutron fluence of 2.0 3 10 12 n cm 22 for imaging, [26][27][28][29][30] with the etching of NCAR images performed in NaOH solution. 31 In a-autoradiographic imaging, CR-39 detector plates were etched in a 7 N NaOH solution at 70°C for 2 h to reveal tracks. However, imaging results would include the recoiled proton tracks produced by the biogenically abundant nuclide, 14…”

Boron Studies in Interdisciplinary Fields Employing Nuclear Track Detectors (NTDs)

“…17. Alpha autoradiography image of a tumour section (left) adapted from Portu et al (2011) and on the right 10 B distributions in VX-2 tumour that shows selective uptake by intra-arterial injection, (adapted from Mikado (2009) The other so called internal boron-modality is related to boron content in many naturally occurring bio-samples. Just to mention one, the natural antibiotic such as boromycin, contains elemental boron.…”