Application of nanotechnology to herbal antioxidants as improved phytomedicine: An expanding horizon

Mishra, Yachana; Amin, Hawraz Ibrahim M.; Mishra, V.; Vyas, Manish; Prabhakar, Pranav Kumar; Gupta, Monika; Kanday, Rajeev; Sudhakar, Kalvatala; Saini, Sumant; Hromić‐Jahjefendić, Altijana; Aljabali, Alaa A. A.; El‐Tanani, Mohamed; Serrano‐Aroca, Ángel; Bakshi, Hamid A.; Tambuwala, Murtaza M.

doi:10.1016/j.biopha.2022.113413

Cited by 25 publications

(16 citation statements)

References 108 publications

(110 reference statements)

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“…The DPPH radical scavenging and ORAC assays are common tests applied to assess the antioxidant action of nano-based formulations [ 43 ]. The radical neutralizing potential is based on the electron-donating property of radical DDPH coming from substances that present several hydroxyl groups in aromatic rings, such as flavonoids.…”

Section: Resultsmentioning

confidence: 99%

“…The radical neutralizing potential is based on the electron-donating property of radical DDPH coming from substances that present several hydroxyl groups in aromatic rings, such as flavonoids. The active substances that are able to donate hydrogen are considered free radical scavengers [ 43 , 44 ]. Meanwhile, ORAC method estimates the property of antioxidants to protect molecule susceptible to a free radical attack [ 43 ].…”

Section: Resultsmentioning

confidence: 99%

“…The active substances that are able to donate hydrogen are considered free radical scavengers [ 43 , 44 ]. Meanwhile, ORAC method estimates the property of antioxidants to protect molecule susceptible to a free radical attack [ 43 ]. Spectrophotometric tests can hinder results interpretation because of nanoparticles spectral interference.…”

Section: Resultsmentioning

confidence: 99%

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Nanoencapsulation of Vaccinium ashei Leaf Extract in Eudragit® RS100-Based Nanoparticles Increases Its In Vitro Antioxidant and In Vivo Antidepressant-like Actions

et al. 2023

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Depression is a major psychiatric disorder in Brazil and worldwide. Vaccinium ashei (V. ashei) leaves are cultivation by-products with high bioactive compound levels. Here, a hydroalcoholic extract of V. ashei leaves (HEV) was associated with Eudragit® RS100-based nanoparticles (NPHEV) to evaluate the in vitro antioxidant and in vivo antidepressant-like effects. Interfacial deposition of the preformed polymer method was used for NPHEV production. The formulations were evaluated regarding physicochemical characteristics, antioxidant activity (DPPH radical scavenging and oxygen radical absorbance capacity), and antidepressant-like action (1–25 mg/kg, single intragastric administration) assessed in forced swimming and tail suspension tests in male Balb-C mice. The NPHEV presented sizes in the nanometric range (144–206 nm), positive zeta potential values (8–15 mV), polydispersity index below 0.2, and pH in the acid range. The phenolic compound content was near the theoretical values, although the rutin presented higher encapsulation efficiency (~95%) than the chlorogenic acid (~60%). The nanoencapsulation improved the HEV antioxidant effect and antidepressant-like action by reducing the immobility time in both behavioral tests. Hence, Eudragit® RS100 nanoparticles containing HEV were successfully obtained and are a promising alternative to manage depression.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Nanoencapsulation of Vaccinium ashei Leaf Extract in Eudragit® RS100-Based Nanoparticles Increases Its In Vitro Antioxidant and In Vivo Antidepressant-like Actions

et al. 2023

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“…Further, resveratrol does not only work as a direct antioxidant system, but also indirectly acts as an endogenous antioxidant system inducer, which may contribute to cellular defense. Additionally, these polyphenolic components' antioxidant properties may be due to their functions as gene regulators [1,8]. It was discovered that the inhibition of ROS generation was achieved by down regulating the expression of NADPH oxidase.…”

Section: Nano-resveratrolmentioning

confidence: 99%

“…Since ancient times, herbal remedies or dietary components have been extensively utilized all over the world and acknowledged by physicians and patients for their superior therapeutic impact over allopathic medicines. The reason for such usage is the minimal side effects compared to chemical therapeutic agents used in modern medicinal systems [1,2]. Drug delivery methods can accomplish herbal or spice treatments.…”

Section: Introductionmentioning

confidence: 99%

Nanodelivery of Dietary Polyphenols for Therapeutic Applications

Rudrapal¹,

Mishra

Rani

et al. 2022

Molecules

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Advancement in nanotechnology has unleashed the therapeutic potentials of dietary polyphenols by enhancing bioavailability, improving biological half-life, and allowing site-specific drug delivery. In this review, through citation of relevant literature reports, we discuss the application of nano-pharmaceutical formulations, such as solid lipid nanoparticles, nano-emulsions, nano-crystals, nano-polymersomes, liposomes, ethosomes, phytosomes, and invasomes for dietary polyphenols. Following this, we highlight important studies concerning different combinations of nano formulations with dietary polyphenols (also known as nanophytopolyphenols). We also provide nano-formulation paradigms for enhancing the physicochemical properties of dietary polyphenols. Finally, we highlight the latest patents that were granted on nano-formulations of dietary polyphenols. Based on our review, we observe that nanosized delivery of herbal constituents, spices, and dietary supplements have the ability to improve biological processes and address issues connected with herbal treatments.

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