Application of Nanotechnology for Cancer Treatment

Verma, Monika; Sheoran, Promila; Chaudhury, Ashok

doi:10.1007/978-981-10-4702-2_10

Cited by 11 publications

(8 citation statements)

References 56 publications

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“…These properties enable NPs to facilitate drug delivery and small compounds into cancer cells, and improve the intra-tumor drug concentration with negligible effects on healthy tissues [58]. NPs are ideal for intravenous drug administration because they can localize very selectively in cancerous cells via an enhanced permeability and retention effect (EPR) [59]. The EPR phenomenon is related to the dysfunctional lymphatic networks within the tumorous site, which allows drugs encapsulated in NPs to easily pass through leaky tumor vasculature [59].…”

Section: Nanotechnologymentioning

confidence: 99%

Nanoparticle-Based Drug Delivery Systems for Photodynamic Therapy of Metastatic Melanoma: A Review

Nkune

Abrahamse

2021

IJMS

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Metastatic melanoma (MM) is a skin malignancy arising from melanocytes, the incidence of which has been rising in recent years. It poses therapeutic challenges due to its resistance to chemotherapeutic drugs and radiation therapy. Photodynamic therapy (PDT) is an alternative non-invasive modality that requires a photosensitizer (PS), specific wavelength of light, and molecular oxygen. Several studies using conventional PSs have highlighted the need for improved PSs for PDT applications to achieve desired therapeutic outcomes. The incorporation of nanoparticles (NPs) and targeting moieties in PDT have appeared as a promising strategy to circumvent various drawbacks associated with non-specific toxicity, poor water solubility, and low bioavailability of the PSs at targeted tissues. Currently, most studies investigating new developments rely on two-dimensional (2-D) monocultures, which fail to accurately mimic tissue complexity. Therefore, three-dimensional (3-D) cell cultures are ideal models to resemble tumor tissue in terms of architectural and functional properties. This review examines various PS drugs, as well as passive and active targeted PS nanoparticle-mediated platforms for PDT treatment of MM on 2-D and 3-D models. The overall findings of this review concluded that very few PDT studies have been conducted within 3-D models using active PS nanoparticle-mediated platforms, and so require further investigation.

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Section: Nanotechnologymentioning

confidence: 99%

Nanoparticle-Based Drug Delivery Systems for Photodynamic Therapy of Metastatic Melanoma: A Review

Nkune

Abrahamse

2021

IJMS

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“…Mechanical methods: methods of grinding materials mechanically in mills of various types; type of mechanical grinding is mechanosynthesis, or mechanical alloying; intensive plastic deformation (torsion under pressure, angular pressing, rolling, forging) -essence of methods is multichannel intense plastic shear deformation of processed materials [15]; 2. Physical methods: methods of evaporation (condensation), or gas-phase synthesis of obtaining metals nanopowders; by an electric explosion of a metal wire from which it is planned to obtain a nanopowder; ion-plasma methods are used to obtain non-porous nanocrystalline materials (amorphous alloys and nanocrystalline materials); method of controlled recrystallization from a solid amorphous state; high-frequency induction heating [8], [ 15].…”

Section: Obtaining Nanomaterials As a Basis For Formation Of Principles For Making Appropriate Decisionsmentioning

confidence: 99%

“…Methods that result in thin films include [8], [ Thus, existence of all these methods is due to diversity of composition and nanomaterials properties, which must be taken into account when forming basic principles for obtaining nanomaterials in order to avoid spontaneous degradation. Fundamentally new properties of nanomaterials are provided at micro (but not macro) level.…”

Section: Obtaining Nanomaterials As a Basis For Formation Of Principles For Making Appropriate Decisionsmentioning

confidence: 99%

“…Optical properties -change in electromagnetic spectra of radiation and absorption; scattering; ability to "black body" implement. Stage 6 -assessment of NM for biocompatibility, biodegradability, toxicity [8], [11], [16].…”

Section: Basic Principles Of Decision Making Upon Receipt Of New Nanomaterialsmentioning

confidence: 99%

“…Nanotechnology applications can be used for electrical transformers. Nanofluids, nano-isolation, nanostructured insulators are used [8].…”

Section: Introductionmentioning

confidence: 99%

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Basic Principles of Decision Making upon Receipt of New Nanomaterial

Lyashenko¹,

Mustafa²,

Sotnik³

et al. 2019

IJATCSE

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Review of nanomaterials existing classifications and their preparation methods is carried out. As a result, basic principles of decision-making when obtaining new nanomaterial are determined, which take into account stability, as well as properties when molding products from nanomaterials and directly reproducible properties of materials themselves with check for biocompatibility, biodegradability, and toxicity. It is proposed in decision-making process to pay attention to analysis: nanomaterial behavior in soil (mobility, stability); nanomaterials behavior in water; airborne behavior and photoactivity. It is proposed to classify nanomaterials in terms of their structural components: nanoparticles, carbon nanostructures, thin films. Proposed decision-making algorithm for obtaining new nanomaterial takes into account its safety for human health and environment throughout entire life cycle.

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