Application of nanoparticle tracking analysis for characterising the fate of engineered nanoparticles in sediment-water systems

Luo, Peng; Roca, Alejandro G.; Tiede, Karen; Privett, Katie; Jiang, Jiachao; Pinkstone, John; Ma, Guibin; Veinot, Jonathan G. C.; Boxall, A.

doi:10.1016/j.jes.2016.07.019

Cited by 30 publications

(13 citation statements)

References 52 publications

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“…Methods that combine techniques, such as coupling ICP-MS with size separation techniques, to measure the metal content taking into account particle size of the sample, have advanced significantly. [89,90] Methods such as scanning mobility particle sizing (SMPS), hydrodynamic chromatography-ICP-MS (HDC-ICP-MS), field flow fractionation-ICP-MS (FFF-ICP-MS), single particle ICP-MS (SP-ICP-MS) are each being used to determine environmental concentrations of nanomaterials. As particles are distributed at low concentrations in an environmental sample, combining extraction, enrichment of the target, separation, and then detection provides a method to improve detection.…”

Section: Unknowns Impact Determining Fate and Distribution In The Envmentioning

confidence: 99%

“…As particles are distributed at low concentrations in an environmental sample, combining extraction, enrichment of the target, separation, and then detection provides a method to improve detection. [89,90] Problems arise as the chemicals added in the enrichment process may change the surface chemistry and therefore impact sorting. Devices for online and in situ analysis are still in the process of development and evaluation.…”

Section: Unknowns Impact Determining Fate and Distribution In The Envmentioning

confidence: 99%

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The Known and Unknown about the Environmental Safety of Nanomaterials in Commerce

Klaper

2020

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The widespread nanomaterial use in commercial products has fed significant concern over environmental health and safety ramifications. Initially, little was known as to how these highly reactive particulates interacted with biological systems. Nanomaterials have introduced complexities not normally considered in traditional safety assessments of chemicals and therefore have generated uncertainty in the reliability of standard tests of safety. Advances in understanding the potential impacts of nanomaterials have occurred since their introduction, particularly for those used in the greatest quantities in commerce. The impact of characteristics such as charge, size, surface functionalization, chemical composition, and certain transformations on the potential effect of nanomaterials in the environment continue to move the field forward. However, generalizations of risk based on any one factor across nanomaterials is not possible. Estimating risk also remains difficult due to the introduction of materials that are new and more complex, minimal information on the specific molecular interactions of nanomaterials and organisms, and the need for more tools for measuring the dynamics of nanomaterial state and fate in complex matrices. Finally, exposure estimates are difficult due to difficulty of environmental monitoring which may be exacerbated by lack of information on nanomaterials in products and new uses in the marketplace.

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Section: Unknowns Impact Determining Fate and Distribution In The Envmentioning

confidence: 99%

Section: Unknowns Impact Determining Fate and Distribution In The Envmentioning

confidence: 99%

The Known and Unknown about the Environmental Safety of Nanomaterials in Commerce

Klaper

2020

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“…Nanoparticle tracking analysis (NTA) is a fairly new technique for the measurement of colloidal and nano-sized suspensions, which was first commercialized in 2006 by NanoSight Ltd, Salisbury, UK [29]. It has been used for the study of different kinds of samples, ranging from atmospheric [30], to food [31] and to biological samples [32]. The analysis principles and instrument set-up have been extensively discussed in the literature [33].…”

Section: Uv-vis Spectroscopy Mass Spectrometry and Nanoparticle Tracmentioning

confidence: 99%

On the Aqueous Solution Behavior of C-Substituted 3,1,2-Ruthenadicarbadodecaboranes

et al. 2019

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3,1,2-Ruthenadicarbadodecaborane complexes bearing the [C2B9H11]2− (dicarbollide) ligand are robust scaffolds, with exceptional thermal and chemical stability. Our previous work has shown that these complexes possess promising anti-tumor activities in vitro, and tend to form aggregates (or self-assemblies) in aqueous solutions. Here, we report on the synthesis and characterization of four ruthenium(II) complexes of the type [3-(η6-arene)-1,2-R2-3,1,2-RuC2B9H9], bearing either non-polar (R = Me (2–4)) or polar (R = CO2Me (7)) substituents at the cluster carbon atoms. The behavior in aqueous solution of complexes 2, 7 and the parent unsubstituted [3-(η6-p-cymene)-3,1,2-RuC2B9H11] (8) was investigated via UV-Vis spectroscopy, mass spectrometry and nanoparticle tracking analysis (NTA). All complexes showed spontaneous formation of self-assemblies (108–109 particles mL−1), at low micromolar concentration, with high polydispersity. For perspective applications in medicine, there is thus a strong need for further characterization of the spontaneous self-assembly behavior in aqueous solutions for the class of neutral metallacarboranes, with the ultimate scope of finding the optimal conditions for exploiting this self-assembling behavior for improved biological performance.

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Section: Monitoring Of Crystallisation Pathways Using Ntamentioning

confidence: 99%

“…Rayleigh approximation has been previously used by Luo et al (2016) to explain the light scattering behaviour of gold NPs (Joubert et al, 2011;Luo et al, 2016). Due to the larger size of the ITR, KETO and POS NPs studied in this case, the same approach could not be adopted (Joubert et al, 2011;Luo et al, 2016). Therefore it seemed logical to apply Mie theory (Gallego-Urrea et al, 2011) to determine if NTA could be used to explain changes in NPs, occurring primarily due to solid state transformations and not a change in particle size.…”

Section: Monitoring Of Crystallisation Pathways Using Ntamentioning

confidence: 99%

Comparison of particle size methodology and assessment of nanoparticle tracking analysis (NTA) as a tool for live monitoring of crystallisation pathways

McComiskey

Tajber

2018

European Journal of Pharmaceutics and Biopharmaceutics

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Sample complexity and polydispersity presents challenges surrounding particle size measurements for nanoparticles (NPs). To ensure the delivery of high quality products to the marketplace it is imperative that this task is performed with the greatest accuracy and certainty. For this reason, particle sizing via more than one technique is critical to the success of the formulation process. Dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA) are techniques that size particles based on their Brownian motion in liquid medium. However, each technique has advantages and disadvantages associated with its application. This study was designed with the intent of comparing these techniques in a critical manner. NPs were formed using three Biopharmaceutics Classification System class II compounds: itraconazole, ketoconazole and posaconazole, using an anti-solvent addition, bottom up method. The impact of polyethylene glycol, polyethylene glycol methyl ether and polyethylene glycol dimethyl ether with a molecular weight 2000 Da, as stabilizers, was assessed using these two particle sizing techniques. Mie light scattering theory was successfully used to explain the relationship between material composition and particle scattering power. A change in material refractive index, associated with an amorphous to crystalline solid state transformation, was predominantly responsible for the observed change in the light scattering power of posaconazole nano-dispersions. The innovative application of NTA for the live tracking of these physical processes was explored for the first time. This novel finding can serve to deepen our understanding of the dynamic crystallisation pathway undertaken by a nanoparticle.

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Application of nanoparticle tracking analysis for characterising the fate of engineered nanoparticles in sediment-water systems

Cited by 30 publications

References 52 publications

The Known and Unknown about the Environmental Safety of Nanomaterials in Commerce

The Known and Unknown about the Environmental Safety of Nanomaterials in Commerce

On the Aqueous Solution Behavior of C-Substituted 3,1,2-Ruthenadicarbadodecaboranes

Comparison of particle size methodology and assessment of nanoparticle tracking analysis (NTA) as a tool for live monitoring of crystallisation pathways

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