Application of Nanomicelles in Enhancing Bioavailability and Biological Efficacy of Bioactive Nutrients

Li, Lei; Zeng, Yun; Chen, Minyi; Liu, Gang

doi:10.3390/polym14163278

Cited by 16 publications

(5 citation statements)

References 143 publications

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“…Within the expansive ambit of nanotechnology, nanomicelles have carved out a niche for themselves, specifically in the arena of targeted drug delivery. These nanoconstructs, measuring mere nanometers, have emerged as innovative vehicles, primarily owing to their propensity to enhance the solubility and, by extension, the bioavailability of therapeutic agents [ 105 , 106 , 107 ]. These self-assembled structures, formed from amphiphilic molecules, offer a sanctuary to hydrophobic drugs within their core, shielding them from premature degradation.…”

Section: Resultsmentioning

confidence: 99%

Nano-Based Drug Delivery Systems: Potential Developments in the Therapy of Metastatic Osteosarcoma—A Narrative Review

Luo,

Sun,

Tan

et al. 2023

Pharmaceutics

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Osteosarcoma, a predominant malignant bone tumor, poses significant challenges due to its high metastatic and recurrent nature. Although various therapeutic strategies are currently in use, they often inadequately target osteosarcoma metastasis. This review focuses on the potential of nanoscale drug delivery systems to bridge this clinical gap. It begins with an overview of the molecular mechanisms underlying metastatic osteosarcoma, highlighting the limitations of existing treatments. The review then transitions to an in-depth examination of nanoscale drug delivery technologies, emphasizing their potential to enhance drug bioavailability and reduce systemic toxicity. Central to this review is a discussion of recent advancements in utilizing nanotechnology for the potential intervention of metastatic osteosarcoma, with a critical analysis of several preclinical studies. This review aims to provide insights into the potential applications of nanotechnology in metastatic osteosarcoma therapy, setting the stage for future clinical breakthroughs and innovative cancer treatments.

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Section: Resultsmentioning

confidence: 99%

Nano-Based Drug Delivery Systems: Potential Developments in the Therapy of Metastatic Osteosarcoma—A Narrative Review

Luo,

Sun,

Tan

et al. 2023

Pharmaceutics

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“…The properties of nanomicelles, as a versatile tool, are beneficial in biological applications. The size and shape of micelles are reliant upon the molecular structure of surfactant and the prevailing characteristics of the solution, including pH, temperature, ionic strength, and surfactant concentration [ 77 ].…”

Section: Potential Role Of Nanotechnology In Delivery Of Dmardsmentioning

confidence: 99%

Integrating Nanotechnological Advancements of Disease-Modifying Anti-Rheumatic Drugs into Rheumatoid Arthritis Management

Singh,

Tiwary,

Sharma

et al. 2024

Pharmaceuticals

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Disease-modifying anti-rheumatic drugs (DMARDs) is a class of anti-rheumatic medicines that are frequently prescribed to patients suffering from rheumatoid arthritis (RA). Methotrexate, sulfasalazine, hydroxychloroquine, and azathioprine are examples of non-biologic DMARDs that are being used for alleviating pain and preventing disease progression. Biologic DMARDs (bDMARDs) like infliximab, rituximab, etanercept, adalimumab, tocilizumab, certolizumab pegol, and abatacept have greater effectiveness with fewer adverse effects in comparison to non-biologic DMARDs. This review article delineates the classification of DMARDs and their characteristic attributes. The poor aqueous solubility or permeability causes the limited oral bioavailability of synthetic DMARDs, while the high molecular weights along with the bulky structures of bDMARDs have posed few obstacles in their drug delivery and need to be addressed through the development of nanoformulations like cubosomes, nanospheres, nanoemulsions, solid lipid nanoparticles, nanomicelles, liposome, niosomes, and nanostructured lipid carrier. The main focus of this review article is to highlight the potential role of nanotechnology in the drug delivery of DMARDs for increasing solubility, dissolution, and bioavailability for the improved management of RA. This article also focusses on the different aspects of nanoparticles like their applications in biologics, biocompatibility, body clearance, scalability, drug loading, and stability issues.

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“…Compared with traditional drug delivery modes, nanomaterials as transport carriers for targeted therapy have great superiority. For example, polymeric nanomicelles have the advantages of high structural stability, massive loading of hydrophobic drugs, more effective targeted transport ability and stimulation sensitivity [ 45 ]. In one study, pH-sensitive nanomicelles loaded with drugs were evaluated for the treatment of GN.…”

Section: Application Of Nanomaterials In Gn Treatmentmentioning

confidence: 99%

Application of nanotechnology in the treatment of glomerulonephritis: current status and future perspectives

Zhan,

Zhang,

Chen

et al. 2024

J Nanobiotechnol

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Glomerulonephritis (GN) is the most common cause of end-stage renal failure worldwide; in most cases, it cannot be cured and can only delay the progression of the disease. At present, the main treatment methods include symptomatic therapy, immunosuppressive therapy, and renal replacement therapy. However, effective treatment of GN is hindered by issues such as steroid resistance, serious side effects, low bioavailability, and lack of precise targeting. With the widespread application of nanoparticles in medical treatment, novel methods have emerged for the treatment of kidney diseases. Targeted transportation of drugs, nucleic acids, and other substances to kidney tissues and even kidney cells through nanodrug delivery systems can reduce the systemic effects and adverse reactions of drugs and improve treatment effectiveness. The high specificity of nanoparticles enables them to bind to ion channels and block or enhance channel gating, thus improving inflammation. This review briefly introduces the characteristics of GN, describes the treatment status of GN, systematically summarizes the research achievements of nanoparticles in the treatment of primary GN, diabetic nephropathy and lupus nephritis, analyzes recent therapeutic developments, and outlines promising research directions, such as gas signaling molecule nanodrug delivery systems and ultrasmall nanoparticles. The current application of nanoparticles in GN is summarized to provide a reference for better treatment of GN in the future. Graphical Abstract

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Application of Nanomicelles in Enhancing Bioavailability and Biological Efficacy of Bioactive Nutrients

Cited by 16 publications

References 143 publications

Nano-Based Drug Delivery Systems: Potential Developments in the Therapy of Metastatic Osteosarcoma—A Narrative Review

Nano-Based Drug Delivery Systems: Potential Developments in the Therapy of Metastatic Osteosarcoma—A Narrative Review

Integrating Nanotechnological Advancements of Disease-Modifying Anti-Rheumatic Drugs into Rheumatoid Arthritis Management

Application of nanotechnology in the treatment of glomerulonephritis: current status and future perspectives

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