Flank wear occurs on the relief face of the tool and the life of a tool used in a machining process depends upon the amount of flank wear; so predicting of flank wear is an important requirement for higher productivity and product quality. In the present work, the effects of feed, depth of cut and cutting speed on flank wear of tungsten carbide and polycrystalline diamond (PCD) inserts in CNC turning of 7075 AL alloy with 10 wt% SiC composite are studied; also artificial neural network (ANN) and co-active neuro fuzzy inference system (CANFIS) are used to predict the flank wear of tungsten carbide and PCD inserts. The feed, depth of cut and cutting speed are selected as the input variables and artificial neural network and co-active neuro fuzzy inference system model are designed with two output variables. The comparison between the results of the presented models shows that the artificial neural network with the average relative prediction error of 1.03% for flank wear values of tungsten carbide inserts and 1.7% for flank wear values of PCD inserts is more accurate and can be utilized effectively for the prediction of flank wear in CNC turning of 7075 AL alloy SiC composite. It is also found that the tungsten carbide insert flank wear can be predicted with less error than PCD flank wear insert using ANN. With Regard to the effect of the cutting parameters on the flank wear, it is found that the increase of the feed, depth of cut and cutting speed increases the flank wear. Also the feed and depth of cut are the most effective parameters on the flank wear and the cutting speed has lesser effect.