Application of Multi-Layered Temperature-Responsive Polymer Brushes Coating on Titanium Surface to Inhibit Biofilm Associated Infection in Orthopedic Surgery

Choi, Soo-Kyung; Lee, Hyeon Jun; Hong, Ran; Jo, Byung-Wook; Jo, Suenghwan

doi:10.3390/polym15010163

Cited by 4 publications

(3 citation statements)

References 41 publications

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“…Second, the late infection model was not reproducible for unknown reasons and requires further investigation. A late or chronic infection model is difficult to create, and only a few exist [22,23]. One hypothesis is that the host's immune system may have decreased the bacterial bioburden, resulting in biofilm eradication, but such a hypothesis requires validation through a more precisely constructed study.…”

Section: Discussionmentioning

confidence: 99%

Clinically representative rodent model for biomedical device-associated infection

Lee

Choi

2023

Med Biol Sci Eng

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Bacterial biofilms in the body commonly occur following the implantation of a biomedical device. A mature biofilm results in an extracellular matrix covering the aggregated bacteria and provides protection against antibiotics or the native immune system, rendering diagnosis and treatment difficult. Experiments to eradicate or prevent biofilm formation have been widely performed, with many showing potential for application in vivo. To test the safety and in vivo efficacy of these novel methods, a reliable preclinical animal model is necessary. Here we developed a simple animal model that can be used to recreate medical device-associated infections in vivo. Reproducible Staphylococcus aureus bacterial biofilms were formed on a titanium implant and confirmed by the counting of colony-forming units after sonication and in vivo bioluminescence measurements. We tested our strategy for developing both acute and late-onset infections and confirmed that the model successfully demonstrated bacterial biofilm formation on titanium surfaces, representing acute infection. We believe that this model will be a good option for validating the efficacy and safety of antibacterial strategies for orthopedic surgery.

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Section: Discussionmentioning

confidence: 99%

Clinically representative rodent model for biomedical device-associated infection

Lee

Choi

2023

Med Biol Sci Eng

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“…Choi et al used copolymers made up of 2-hydroxyethyl methacrylate and diethylene glycol methyl ether methacrylate to prepare a multi-layered temperature-responsive polymer brush (MLTRPB) coating on a Ti surface, which triggered a significant release of antibiotics from the coating at 38°C–40 °C, the local temperature that may be reached during infection. The coating showed good antimicrobial efficacy in both in vitro and in vivo experiments ( Choi et al, 2022 ). In addition, certain specific enzymes released by bacteria during infection can also act as triggers.…”

Section: Antimicrobial Coatingsmentioning

confidence: 99%

Overview of strategies to improve the antibacterial property of dental implants

Zhai,

Tian,

Shi

et al. 2023

Front. Bioeng. Biotechnol.

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The increasing number of peri-implant diseases and the unsatisfactory results of conventional treatment are causing great concern to patients and medical staff. The effective removal of plaque which is one of the key causes of peri-implant disease from the surface of implants has become one of the main problems to be solved urgently in the field of peri-implant disease prevention and treatment. In recent years, with the advancement of materials science and pharmacology, a lot of research has been conducted to enhance the implant antimicrobial properties, including the addition of antimicrobial coatings on the implant surface, the adjustment of implant surface topography, and the development of new implant materials, and significant progress has been made in various aspects. Antimicrobial materials have shown promising applications in the prevention of peri-implant diseases, but meanwhile, there are some shortcomings, which leads to the lack of clinical widespread use of antimicrobial materials. This paper summarizes the research on antimicrobial materials applied to implants in recent years and presents an outlook on the future development.

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“…MLTRPB substantially decreased the bacterial bioburden on the implant, correlating with the number of layers again. Using a four-layer MLTRPB resulted in a three-log reduction in bacterial biofilms, which they considered significant in clinical practice [ 66 ].…”

Section: Current Advances In the Use Of Smart Polymers For Combating ...mentioning

confidence: 99%

Advances in Material Modification with Smart Functional Polymers for Combating Biofilms in Biomedical Applications

Mejía-Manzano,

Vázquez-Villegas,

Prado-Cervantes

et al. 2023

Polymers

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Biofilms as living microorganism communities are found anywhere, and for the healthcare sector, these constitute a threat and allied mechanism for health-associated or nosocomial infections. This review states the basis of biofilms and their formation. It focuses on their relevance for the biomedical sector, generalities, and the major advances in modified or new synthesized materials to prevent or control biofilm formation in biomedicine. Biofilm is conceptualized as an aggregate of cells highly communicated in an extracellular matrix, which the formation obeys to molecular and genetic basis. The biofilm offers protection to microorganisms from unfavorable environmental conditions. The most frequent genera of microorganisms forming biofilms and reported in infections are Staphylococcus spp., Escherichia spp., and Candida spp. in implants, heart valves, catheters, medical devices, and prostheses. During the last decade, biofilms have been most commonly related to health-associated infections and deaths in Europe, the United States, and Mexico. Smart, functional polymers are materials capable of responding to diverse stimuli. These represent a strategy to fight against biofilms through the modification or synthesis of new materials. Polypropylene and poly-N-isopropyl acrylamide were used enough in the literature analysis performed. Even smart polymers serve as delivery systems for other substances, such as antibiotics, for biofilm control.

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Application of Multi-Layered Temperature-Responsive Polymer Brushes Coating on Titanium Surface to Inhibit Biofilm Associated Infection in Orthopedic Surgery

Cited by 4 publications

References 41 publications

Clinically representative rodent model for biomedical device-associated infection

Clinically representative rodent model for biomedical device-associated infection

Overview of strategies to improve the antibacterial property of dental implants

Advances in Material Modification with Smart Functional Polymers for Combating Biofilms in Biomedical Applications

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