Application of Montmorillonite Clay and Mesoporous Carbon as Modifiers to Carbon Paste Electrode for Determination of Amoxicillin Drug

Abstract

Two types of mesoporous carbon (MC and MC − ) were prepared. MC was synthesized using the prepared SBA-15 as a hard template and sucrose as the carbon source. While, MC − has been fabricated using polyethylene-polypropylene glycol (F127) as a soft template and resorcinol as a carbon source. The prepared mesoporous carbon and commercial sodium montmorillonite clay (Na-MMT) were characterized using X-ray diffraction (XRD), N 2 adsorption isotherm (BET), scanning electron microscope (SEM) and transmission electron microscope (TEM). Carbon paste electrode modified with MC, MC − as well as Na-MMT were used as sensors for determination of amoxicillin drug using linear sweep and square wave adsorptive anodic stripping voltammetry (LS-and SW-AdASV) methods. The most developed peak current was observed at MC modified carbon paste electrode (MC/CPE) indicating its strongest adsorptive property which can be attributed to its highest surface area and lowest charge transfer resistance. MC/CPE was successfully applied for the determination of amoxicillin drug in its pharmaceutical formulation and in biological fluids. LOD values of 6.0 × 10 −9 and 1.5 × 10 −9 M bulk amoxicillin were obtained using LS-and SW-AdASV, respectively.

Recent progress in the development of porous carbon-based electrodes for sensing applications

“…Abdel-Galeil et al 92 prepared a CPE, for the determination of amoxicillin, modified with two types of mesoporous carbons (named by the authors as MC and MC − ), MC prepared using SBA-15 as a hard template and sucrose as a carbon source, and MC − synthesized using polyethylene-polypropylene glycol as a soft-template and resorcinol as a carbon source. The results indicated that the electrode modified with MC exhibited a higher peak current intensity associated with the acceleration of electron transfer process attributed to: (i) the greater conductivity and (ii) the adsorption of the analyte at the carbon surface due to its highest surface area (1421 m 2 g −1 ) compared with the MC − sample (156 m 2 g −1 ).…”

Synthesis of Tin/Tin Oxide (Sn-SnO2) Microparticles Scattered on Natural Phosphate and Its Utilization in Capturing Amoxicillin Antibiotic in Real Water Samples

“…61 The modification of electrode's surface with suitable modifiers, increases the sensitivity, precision, and selectivity. [62][63][64] Several materials have already been employed to modify the carbon paste electrode for the determination of amoxicillin, such as clinoptilolite zeolite (Cu(II)-NCL), 62 nickel-curcumin complex, 2 Montmorillonite Clay and Mesoporous Carbon, 65 [N,N-ethylenebis (salicylideneaminato)] oxovanadium(IV), 66 and ZnO/CNTs nanocomposite/catechol. 67 In this regard, we have been interested in using phosphate compounds as a modifier of carbon electrodes to detect various chemical compounds, 68,69 due to their ability to increase voltammetric signals allowing lower detection limits and higher sensitivity.…”