Application of miniaturized near-infrared spectroscopy for quality control of extemporaneous orodispersible films

Foo, Wen Chin; Widjaja, Effendi; Khong, Yuet Mei; Gokhale, Rajeev; Chan, Sui Yung

doi:10.1016/j.jpba.2017.11.068

Cited by 15 publications

(5 citation statements)

References 17 publications

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“…There has been tremendous interest in miniaturizing spectrometers to enable a broader range of applications 1 . There are two classes of compact spectrometers: waveguide-coupled 2–10 and free-space coupled 11–21 . The waveguide-coupled spectrometers have limited applications, because they require delicate couplers and do not offer spatial information.…”

Section: Introductionmentioning

confidence: 99%

Single-shot on-chip spectral sensors based on photonic crystal slabs

et al. 2019

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Miniaturized spectrometers have significant potential for portable applications such as consumer electronics, health care, and manufacturing. These applications demand low cost and high spectral resolution, and are best enabled by single-shot free-space-coupled spectrometers that also have sufficient spatial resolution. Here, we demonstrate an on-chip spectrometer that can satisfy all of these requirements. Our device uses arrays of photodetectors, each of which has a unique responsivity with rich spectral features. These responsivities are created by complex optical interference in photonic-crystal slabs positioned immediately on top of the photodetector pixels. The spectrometer is completely complementary metal–oxide–semiconductor (CMOS) compatible and can be mass produced at low cost.

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Section: Introductionmentioning

confidence: 99%

Single-shot on-chip spectral sensors based on photonic crystal slabs

et al. 2019

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“…In addition to those already discussed in the Introduction, further examples can be found. For instance, the study conducted by Foo et al [ 46 ], who applied NIR as a quality control tool for the identification and quantification of drug content in extemporaneous orodispersible films (ODFs) to lower the cost and complexity of routine analysis performed using HPLC. Calibration models were developed for the identification of ODFs containing five different drugs and for the quantification of ondansetron (OND).…”

Section: Discussionmentioning

confidence: 99%

Coupling of NIR Spectroscopy and Chemometrics for the Quantification of Dexamethasone in Pharmaceutical Formulations

et al. 2023

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Counterfeit or substandard drugs are pharmaceutical formulations in which the active pharmaceutical ingredients (APIs) have been replaced or ingredients do not comply with the drug leaflet. With the outbreak of the COVID-19 pandemic, fraud associated with the preparation of substandard or counterfeit drugs is expected to grow, undermining health systems already weakened by the state of emergency. Analytical chemistry plays a key role in tackling this problem, and in implementing strategies that permit the recognition of uncompliant drugs. In light of this, the present work represents a feasibility study for the development of a NIR-based tool for the quantification of dexamethasone in mixtures of excipients (starch and lactose). Two different regression strategies were tested. The first, based on the coupling of NIR spectra and Partial Least Squares (PLS) provided good results (root mean square error in prediction (RMSEP) of 720 mg/kg), but the most accurate was the second, a strategy exploiting sequential preprocessing through orthogonalization (SPORT), which led (on the external set of mixtures) to an R2pred of 0.9044, and an RMSEP of 450 mg/kg. Eventually, Variable Importance in Projection (VIP) was applied to interpret the obtained results and determine which spectral regions contribute most to the SPORT model.

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“…Low-temperature curing by IR lamps or UV/Vis light is the most commonly used mechanism in 3D inkjet printing processes. They can be quickly set up during 3D inkjet printer setup [84].…”

Section: Three-dimensional Inkjet Printingmentioning

confidence: 99%

“…A high printing temperature and an organic solvent are required to produce the ink containing these materials; these conditions limit their applications for drug delivery. Three-dimensional inkjet printing requires inks with low viscosity (10-20 mPa s) and surface tension (28-42 mNm −1 ) for appropriate droplet generation [84,114]. Therefore, the nature and type of inks that can be employed are minimal, thereby diminishing the number of active materials that could be printed [114,115].…”

Section: Polymers For 3d Printing Technologiesmentioning

confidence: 99%

“…On the other hand, compatibility with lithographic processes is requested for the hydrogel inks suitable for light-based 3DP [123]. Xu et al [127] investigated 3D-printed OFs Three-dimensional inkjet printing requires inks with low viscosity (10-20 mPa s) and surface tension (28-42 mNm −1 ) for appropriate droplet generation [84,114]. Therefore, the nature and type of inks that can be employed are minimal, thereby diminishing the number of active materials that could be printed [114,115].…”

Section: Polymers For 3d Printing Technologiesmentioning

confidence: 99%

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Three-Dimensional Printing Technologies in Oral Films Manufacturing—A Minireview

Ozon,

Sarbu,

Popovici

et al. 2023

Processes

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The interest in buccal drug delivery is under consideration due to some distinct properties compared to the traditional pharmaceutical formulations for oral administration: significantly higher bioavailability, a faster absorption rate of the drug, and substantial compliance for special needs patients. Oral films are obtained through various technologies, from conventional tools to 3D and 4D printing approaches. This minireview aims to describe the current additive manufacturing technologies in oral film fabrication, display their advantages and limitations, and discuss various formulation strategies. It also provides advanced data regarding synthetic and natural polymers used in 3D printing technologies for oral films. Moreover, it shows the most recent studies with 3D-printed orodispersible films and mucoadhesive buccal films manufactured through previously analyzed methods. Finally, conclusions and future perspectives are also briefly summarized.

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Application of miniaturized near-infrared spectroscopy for quality control of extemporaneous orodispersible films

Cited by 15 publications

References 17 publications

Single-shot on-chip spectral sensors based on photonic crystal slabs

Single-shot on-chip spectral sensors based on photonic crystal slabs

Coupling of NIR Spectroscopy and Chemometrics for the Quantification of Dexamethasone in Pharmaceutical Formulations

Three-Dimensional Printing Technologies in Oral Films Manufacturing—A Minireview

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