Application of Microreactor Technology in Process Development

Abstract

The microreactor technology is an efficient tool for kilogramscale syntheses in continuous mode and is particularly effective for hazardous reactions that do not allow scale-up in conventional reactors. Applications to several classes of reactions including highly exothermic reactions, high-temperature reactions, reactions with unstable intermediates, and reactions involving hazardous reagents are described herein.

Toward Greener Nanosynthesis

“…Kilogram scale production of organic compounds has been demonstrated with benchtop microreactors. 114 The primary benefit of the microreactor approach for green nanosynthesis is the opportunity to gain greater control of process conditions (speed of mixing reagents and adding reagents at later stages of the reaction, residence time within the reaction zone, and speed of reaction quenching) and perhaps to monitor the reaction process in real time with integrated sensors. A recent review describes the merits of this approach for the production of compound semiconductor nanoparticles.…”

From form to function: Crystallization of active pharmaceutical ingredients

“…31,32 However, the application of this technology to crystallization has, thus far, been rather limited, with the vast majority of the publications in the area focused on generating nanoparticles of inorganic molecules. The small channel sizes (which give microreactors their unique capabilities) are highly prone to plugging, and create practical limitations on the size of the particles that can be produced.…”

The Claisen Rearrangement – Part 2: Impact Factor Analysis of the Claisen Rearrangement, in Batch and in Flow

“…Enhanced heat and mass transfer can essentially inhibit side and diminish follow-up reactions, respectively [72,75]. The substrate reaches the energy threshold of the reaction quickly after it flows into the heated part of the microchannel and quickly moves out from the part.…”