Application of microneedles combined with dendritic cell-targeted nanovaccine delivery system in percutaneous immunotherapy for triple-negative breast cancer

Weng, Jiaqi; Yang, Jin Hyuk; Wang, Weiwei; Wen, Jiaoli; Fang, Min; Zheng, Gensuo; Xie, Jun; Zheng, Xi; Yan, Qinying; Li, Feng

doi:10.1088/1361-6528/ace97b

Cited by 6 publications

(2 citation statements)

References 56 publications

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“…The excellent biocompatibility of Gantrez S-97, CS, and HA has been proved according to our previous studies, , and no significant cytotoxicity of MgO@PDA nanoparticles was found in all tested groups (Figure g,h). When treated with NIR irradiation, the viability of HUVECs and HSF cells did not decrease significantly, indicating that the temperatures around 48 °C did not cause severe damage to cells.…”

Section: Resultssupporting

confidence: 73%

MgO@polydopamine Nanoparticle-Loaded Photothermal Microneedle Patches Combined with Chitosan Gel Dressings for the Treatment of Infectious Wounds

Zheng,

Xie,

Yao

et al. 2024

ACS Appl. Mater. Interfaces

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As for wound drug delivery, microneedles (MNs) have attracted wide attention. However, while effective at increasing the depth of drug delivery, traditional MNs often have limited drug loads and have difficulty penetrating scabs on wounds. Herein, we develop a drug delivery system combining MgO@ polydopamine (MgO@PDA) nanoparticle-loaded photothermal MN patches and chitosan (CS) gel to inhibit the formation of scabs and deliver sufficient drugs into deep tissue. When inserted into the wound, the MN system can keep the wound bed moist and weakly acidic to inhibit the formation of scabs and accelerate wound closure. The released MgO@PDA nanoparticles from both the tips and the backing layer, which immensely increase the drug load, continuously release Mg 2+ in the moist, weakly acidic wound bed, promoting tissue migration and the formation of microvessels. MgO@PDA nanoparticles show excellent antibacterial activity under near-infrared irradiation synergized with the CS gel, and the PDA coating can also overcome the adverse effects of oxidative stress. Through in vitro and in vivo experiments, the MN system showed remarkable antibacterial, antioxidant, anti-inflammatory, and pro-angiogenic effects, indicating its potential in the treatment of infectious wounds.

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Section: Resultssupporting

confidence: 73%

MgO@polydopamine Nanoparticle-Loaded Photothermal Microneedle Patches Combined with Chitosan Gel Dressings for the Treatment of Infectious Wounds

Zheng,

Xie,

Yao

et al. 2024

ACS Appl. Mater. Interfaces

Self Cite

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“…It possesses several advantageous characteristics, including low cost, ease of manufacturing, biological origin, high biocompatibility and biodegradability [175]. These properties have facilitated the development of chitosan as a vaccine carrier in the past decade [176][177][178][179]. Chitosan has proven to be suitable for mucosal vaccine delivery and to be able to improve mucosal immune response [180].…”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

The quest for nanoparticle-powered vaccines in cancer immunotherapy

Sun,

Zhao,

et al. 2024

J Nanobiotechnol

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Despite recent advancements in cancer treatment, this disease still poses a serious threat to public health. Vaccines play an important role in preventing illness by preparing the body's adaptive and innate immune responses to combat diseases. As our understanding of malignancies and their connection to the immune system improves, there has been a growing interest in priming the immune system to fight malignancies more effectively and comprehensively. One promising approach involves utilizing nanoparticle systems for antigen delivery, which has been shown to potentiate immune responses as vaccines and/or adjuvants. In this review, we comprehensively summarized the immunological mechanisms of cancer vaccines while focusing specifically on the recent applications of various types of nanoparticles in the field of cancer immunotherapy. By exploring these recent breakthroughs, we hope to identify significant challenges and obstacles in making nanoparticle-based vaccines and adjuvants feasible for clinical application. This review serves to assess recent breakthroughs in nanoparticle-based cancer vaccinations and shed light on their prospects and potential barriers. By doing so, we aim to inspire future immunotherapies for cancer that harness the potential of nanotechnology to deliver more effective and targeted treatments. Graphical abstract

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Exploring the interplay between triple‐negative breast cancer stem cells and tumor microenvironment for effective therapeutic strategies

Zou,

Luo,

Wang

et al. 2024

Journal Cellular Physiology

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Triple‐negative breast cancer (TNBC) is a highly aggressive and metastatic malignancy with poor treatment outcomes. The interaction between the tumor microenvironment (TME) and breast cancer stem cells (BCSCs) plays an important role in the development of TNBC. Owing to their ability of self‐renewal and multidirectional differentiation, BCSCs maintain tumor growth, drive metastatic colonization, and facilitate the development of drug resistance. TME is the main factor regulating the phenotype and metastasis of BCSCs. Immune cells, cancer‐related fibroblasts (CAFs), cytokines, mesenchymal cells, endothelial cells, and extracellular matrix within the TME form a complex communication network, exert highly selective pressure on the tumor, and provide a conducive environment for the formation of BCSC niches. Tumor growth and metastasis can be controlled by targeting the TME to eliminate BCSC niches or targeting BCSCs to modify the TME. These approaches may improve the treatment outcomes and possess great application potential in clinical settings. In this review, we summarized the relationship between BCSCs and the progression and drug resistance of TNBC, especially focusing on the interaction between BCSCs and TME. In addition, we discussed therapeutic strategies that target the TME to inhibit or eliminate BCSCs, providing valuable insights into the clinical treatment of TNBC.

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Application of microneedles combined with dendritic cell-targeted nanovaccine delivery system in percutaneous immunotherapy for triple-negative breast cancer

Cited by 6 publications

References 56 publications

MgO@polydopamine Nanoparticle-Loaded Photothermal Microneedle Patches Combined with Chitosan Gel Dressings for the Treatment of Infectious Wounds

MgO@polydopamine Nanoparticle-Loaded Photothermal Microneedle Patches Combined with Chitosan Gel Dressings for the Treatment of Infectious Wounds

The quest for nanoparticle-powered vaccines in cancer immunotherapy

Exploring the interplay between triple‐negative breast cancer stem cells and tumor microenvironment for effective therapeutic strategies

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