Application of microfluidic chip technology in pharmaceutical analysis: A review

Cui, Ping; Wang, Sicen

doi:10.1016/j.jpha.2018.12.001

Cited by 245 publications

(129 citation statements)

References 120 publications

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“…Combining Equations (6), (7), (12), and (13) with appropriate boundary conditions, sound fields and acoustic streaming fields produced by multiple vibration sources can be solved numerically using the commercial finite element software, COMSOL Multiphysics (version 5.4). The computational process consists of the following three steps.…”

Section: Theory and Simulationmentioning

confidence: 99%

“…In the second step, computed vibration velocity and sound pressure of the sound field were used to calculate the mass source term −∇•ρ 1 u 1 of Equation (12) and the volume force term…”

Section: Theory and Simulationmentioning

confidence: 99%

“…Contactless manipulation of micro-/nano-scale particles and biosamples in a microfluidic chamber is of great importance [1][2][3] due to the increasing requirement to carry out elementary operations like trapping [4,5], rotation [6,7], separation [8], and concentration [9], which are an essential technique for biological researches and exhibit numerous commercial applications in the bioengineering and pharmaceutical industries [10][11][12]. Various microfluidic manipulation methods for capturing [13,14], transporting [15], rotating [16], and separating [17] of micro-/nano-scale objects have been provided and verified in laboratories worldwide.…”

Section: Introductionmentioning

confidence: 99%

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Diversity of 2D Acoustofluidic Fields in an Ultrasonic Cavity Generated by Multiple Vibration Sources

et al. 2019

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Two-dimensional acoustofluidic fields in an ultrasonic chamber actuated by segmented ring-shaped vibration sources with different excitation phases are simulated by COMSOL Multiphysics. Diverse acoustic streaming patterns, including aggregation and rotational modes, can be feasibly generated by the excitation of several sessile ultrasonic sources which only vibrate along radial direction. Numerical simulation of particle trajectory driven by acoustic radiation force and streaming-induced drag force also demonstrates that micro-scale particles suspended in the acoustofluidic chamber can be trapped in the velocity potential well of fluid flow or can rotate around the cavity center with the circumferential acoustic streaming field. Preliminary investigation of simple Russian doll- or Matryoshka-type configurations (double-layer vibration sources) provide a novel method of multifarious structure design in future researches on the combination of phononic crystals and acoustic streaming fields. The implementation of multiple segmented ring-shaped vibration sources offers flexibility for the control of acoustic streaming fields in microfluidic devices for various applications. We believe that this kind of acoustofluidic design is expected to be a promising tool for the investigation of rapid microfluidic mixing on a chip and contactless rotational manipulation of biosamples, such as cells or nematodes.

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Section: Theory and Simulationmentioning

confidence: 99%

Section: Theory and Simulationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Diversity of 2D Acoustofluidic Fields in an Ultrasonic Cavity Generated by Multiple Vibration Sources

et al. 2019

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“…They also serve to perform various microfluidic related operations such as the sampling, filtration, dilution, reaction, mixing, and biosensing [4, 5]. Because of such diverse applications, they are readily used as an integral component of the Micro Total Analysis Systems (μTAS) [6], Lab-on-a-Chip and Point of Care (POC) testing systems [7] that caters to various applications such as drug delivery and pharmaceutical applications [8]. Measurement of flow and pressure is central to the design of micro pumps for such applications.…”

Section: Introductionmentioning

confidence: 99%

A novel two-indenter based micro-pump for lab-on-a-chip application: modeling and characterizing flows for a non-Newtonian fluid

Avvari

2020

Preprint

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Inspired by the feeding mechanisms of a nematode, a novel two-indenter (2I) micropump is analyzed theoretically for transport and mixing of a non-Newtonian fluid for the purpose of lab-on-a-chip applications. Considering that the viscous forces dominate the flows in microscopic regime, the concept lubrication theory was adopted to device the two-dimensional flow model of the problem. By approximating the movements of the indenter as a sinusoidal function, the details of the flow were investigated for variations in -frequency of contraction of the first value keeping the second valve at higher occlusion, and occlusion. The study indicates that occlusive nature of the second valve leads to the large pressure barrier which prevents the fluid to enter into the neighboring compartment. Transport occurs as the lumen opens to develop a suction pressure. Pressure barrier is found to be highest for dilatants followed by Newtonian and pseudo-plastics. Shear stress dependency on frequency the contraction of the first value is highest for lower values of flow behavior index. In conclusion, the study provides details connecting the flows resulting from the indentation of the front-end indenter to the frequency of indentation, geometry and rheology of the fluid, thus facilitating optimal design of the micropumps.

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“…Microfluidics provides an excellent tool to develop the aforementioned artificial cell environment [22][23][24] . Currently, such environments have been applied to several artificial organs such as the lung, liver, kidney, and gut 25,26 .…”

mentioning

confidence: 99%

Efficient Drug Screening and Nephrotoxicity Assessment on Co-culture Microfluidic Kidney Chip

Yin

Zhang

et al. 2020

Sci Rep

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The function and susceptibility of various drugs are tested with renal proximal tubular epithelial cells; yet, replicating the morphology and kidneys function using the currently available in vitro models remains difficult. To overcome this difficulty, in the study presented in this paper, a device and a threelayer microfluidic chip were developed, which provides a simulated environment for kidney organs. This device includes two parts: (1) microfluidic drug concentration gradient generator and (2) a flowtemperature controlled platform for culturing of kidney cells. In chip study, renal proximal tubular epithelial cells (RPTECs) and peritubular capillary endothelial cells (PCECs) were screened with the drugs to assess the drug-induced nephrotoxicity. Unlike cells cultured in petri dishes, cells cultured in the microfluidic device exhibited higher performance in terms of both cell growth and drug nephrotoxicity evaluation. It is worth mentioning that a significant decrease in cisplatin-induced nephrotoxicity was found because of the intervention of cimetidine in the microfluidic device. In conclusion, the different in the cell performance between the microfluidic device and the petri dishes demonstrates the physiological relevance of the nephrotoxicity screening technology along with the microfluidic device developed in this study. Furthermore, this technology can also facilitate the development of reliable kidney drugs and serve as a useful and efficient test-bed for further investigation of the drug nephrotoxicity evaluation.

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Application of microfluidic chip technology in pharmaceutical analysis: A review

Cited by 245 publications

References 120 publications

Diversity of 2D Acoustofluidic Fields in an Ultrasonic Cavity Generated by Multiple Vibration Sources

Diversity of 2D Acoustofluidic Fields in an Ultrasonic Cavity Generated by Multiple Vibration Sources

A novel two-indenter based micro-pump for lab-on-a-chip application: modeling and characterizing flows for a non-Newtonian fluid

Efficient Drug Screening and Nephrotoxicity Assessment on Co-culture Microfluidic Kidney Chip

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