Application of Metal–Organic Frameworks (MOFs) in Environmental Biosystems

Zhang, Lu; Zheng, Qingwen; Zhang, Zheng; Li, Huidong; Liu, Xue; Sun, Jialei; Wang, Ruiwen

doi:10.3390/ijms24032145

Cited by 7 publications

(3 citation statements)

References 65 publications

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“…The combination of herbal extracts and MOFs represents a new approach against bacterial antibiotic resistance. Furthermore, MOFs can serve as substrate materials for various application scenarios, including nanoformulations, and masks ( Qiao et al., 2020 ; Duan et al., 2021 ; Zhang et al., 2023 ). This opens up new possibilities for the application forms of herbal extracts.…”

Section: Discussionmentioning

confidence: 99%

Utilization of the Shensheng-Piwen changed medicinal powder extracts combines metal-organic frameworks as an antibacterial agent

Jin,

Zhang,

et al. 2024

Front. Cell. Infect. Microbiol.

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IntroductionWidespread opportunistic pathogens pose a serious threat to global health, particularly in susceptible hospital populations. The escalating crisis of antibiotic resistance highlights the urgent need for novel antibacterial agents and alternative treatment approaches. Traditional Chinese Medicine (TCM) and its compounds have deep roots in the treatment of infectious diseases. It has a variety of active ingredients and multi-target properties, opening up new avenues for the discovery and development of antimicrobial drugs.MethodsThis study focuses on assessing the efficacy of the Shensheng-Piwen changed medicinal powder (SPC) extracts against opportunistic pathogen infections by broth microdilution and agar disc diffusion methods. Additionally, biofilm inhibition and eradication assays were performed to evaluate the antibiofilm effects of SPC extracts.ResultsMetabolite profiles were analyzed by LC-MS. Furthermore, the potential synergistic effect between SPC and Metal-Organic Framework (MOF) was investigated by bacterial growth curve analysis. The results indicated that the SPC extracts exhibited antibacterial activity against S. aureus, with a minimum inhibitory concentration (MIC) of 7.8 mg/mL (crude drug concentration). Notably, at 1/2 MIC, the SPC extracts significantly inhibited biofilm formation, with over 80% inhibition, which was critical in tackling chronic and hospital-acquired infections. Metabolomic analysis of S. aureus revealed that SPC extracts induced a notable reduction in the levels of various metabolites, including L-proline, L-asparagine. This suggested that the SPC extracts could interfere with the metabolism of S. aureus. Meanwhile, the growth curve experiment proved that SPC extracts and MOFs had a synergistic antibacterial effect.DiscussionIn conclusion, the present study highlights the potential of SPC extracts as a novel antibacterial agent against S. aureus infections, with promising biofilm inhibition properties. The observed synergistic effect between SPC extracts and MOFs further supports the exploration of this combination as an alternative treatment approach.

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Section: Discussionmentioning

confidence: 99%

Utilization of the Shensheng-Piwen changed medicinal powder extracts combines metal-organic frameworks as an antibacterial agent

Jin,

Zhang,

et al. 2024

Front. Cell. Infect. Microbiol.

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“…Metal–organic frameworks (MOFs) are a new class of coordination porous crystalline materials formed by self-assembling organic ligands with metal ions, which are characterized by high specific surface area, multiple active sites, diverse structures, tailorability, and easy functionalization. 6 However, due to the unstable structure, small specific surface area, and wide band gap of the initial MOFs, their application in the field of photocatalysis was limited. Therefore, researchers have tried to practice different methods to modify MOFs to improve their application value.…”

Section: Introductionmentioning

confidence: 99%

Highly Efficient Photocatalytic Degradation of Tetracycline by Modifying UiO-66 via Different Regulation Strategies

Jia,

Wang,

et al. 2023

ACS Omega

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Wastewater containing organic pollutants cause potential harm to the environment and human health. A series of zirconium-organic frameworks (UiO-66) and their composites were synthesized by solvothermal methods, including band gap adjustment, heterojunction construction, and metal ion doping. For the model pollutant tetracycline (TC), all of the prepared catalysts could achieve effective degradation of it. Therein, the degradation efficiency of tetracycline could reach 95% under the UV irradiation with the aid of the catalyst, in which the UiO-66-NDC was modified with P–C3N4. The free radical capture experiments demonstrated that the superoxide radical (•O2 –) was the main oxidizing species for the photodegradation of tetracycline. Hence, the improvement strategy of the catalyst would provide some enlightenment for the development of more efficient photocatalysts for the degradation of organic dyes in wastewater.

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“…Wang et al [ 13 ] reviewed the recent progress of MOFs and MOF-derived materials, as well as their function and influences on performance in environmental biosystems. In this review, the interaction between these biocomponents and MOFs (or MOF-derived materials) was also discussed, also helping to guide the rational design of MOF-related materials and facilitate a better understanding of their interaction with biocomponents.…”

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confidence: 99%