Application of metagenomic next-generation sequencing for rapid molecular identification in spinal infection diagnosis
Hui Lv,
Sheng Liao,
Zhenzhen Shi
et al.
Abstract:ObjectiveThis study aimed to determine the sensitivity and specificity of metagenomic next−generation sequencing (mNGS) for detecting pathogens in spinal infections and to identify the differences in the diagnostic performance between mNGS and targeted next−generation sequencing (tNGS).MethodsA total of 76 consecutive patients with suspected spinal infections who underwent mNGS, culture, and histopathological examinations were retrospectively studied. The final diagnosis of the patient was determined by combin… Show more
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