The
malfunctioning in the release of acetylcholine (ACh+),
leading to consequential damages in the neural system, has become
an impulsion for the development of numerous progressive transport
and detection gadgets. However, several challenges, such as laterality
and complexity of transport devices, low precision of amperometric
detection systems, and sumptuous, multistaged enzymatic quantification
methods, have not yet been overcome. Herein, ionomers, because of
their selective ion transporting nature, are chosen as suitable candidates
for being implemented into both targeted ACh+ delivery
and sensing systems. Based on these two approaches, for the very first
time in the literature, the disulfonated poly(arylene ether sulfone)
membrane is concurrently (i) used in the mimicry of transduction of
the electrical-to-ionic signal in a neural network as “Acetylcholine
Pen” (ACh+ Pen) and (ii) operated as a highly sensitive,
conductivity-based ACh+ quantifier. Our dual device, being
able to operate under an actual action potential of 55 mVbias, shows a strong potential of future applicability in real-time ionic
delivery-and-sensing systems.