Application of Mass Spectrometry in Pancreatic Cancer Translational Research

Abstract

Pancreatic cancer (PC) is one of the most common malignant tumors in the digestive tract worldwide, with increased morbidity and mortality. In recent years, with the development of surgery, chemotherapy, radiotherapy, targeted therapy, and immunotherapy, and the change of the medical thinking model, remarkable progress has been made in researching comprehensive diagnosis and treatment of PC. However, the present situation of diagnostic and treatment of PC is still unsatisfactory. There is an urgent need for academia to fully integrate the basic research and clinical data from PC to form a research model conducive to clinical translation and promote the proper treatment of PC. This paper summarized the translation progress of mass spectrometry (MS) in the pathogenesis, diagnosis, prognosis, and PC treatment to promote the basic research results of PC into clinical diagnosis and treatment.

Screening of Exosome-Derived Proteins and Their Potential as Biomarkers in Diagnostic and Prognostic for Pancreatic Cancer

“…These proteins are linked to abundant immune infiltrates, immune responses, and senescence, and serve as prognostic markers for various types of cancer [ 35 , 36 , 37 ], including pancreatic diseases [ 38 , 39 ]. In pancreatic cancer, the accumulation of CFB is associated with immune evasion, making it a potential target for immunotherapy [ 40 ]. On the other hand, C3 and C5 have been suggested as targets for immunotherapy and as follow-up markers in pan-cancer scenarios [ 38 ].…”

Proline metabolism reprogramming of trained macrophages induced by early respiratory infection combined with allergen sensitization contributes to development of allergic asthma in childhood of mice

“…The metabolic profiles of amino acids in asthmatic children were significantly different from those of normal children ( 55 ). Trained immune cells have many similar metabolic characteristics to cancer cells, for example, they are both energy-intensive cells, and have metabolic disorders, including amino acid and glucose metabolism disorders ( 56 – 58 ). The disorder of proline biosynthesis promotes the occurrence of various cancers, and proline is the “limiting amino acid” of cancer cells ( 29 , 59 ).…”

Pancreatic Cystic Lesions: A Focused Review on Cyst Clinicopathological Features and Advanced Diagnostics

“…Mass spectrometry is a useful tool that measures the mass-to-charge ratio of ions and allows for the identification of the molecular weight, structure, and chemical formula of pure substances [115,116]. Additionally, mass spectrometry has been a helpful noninvasive tool that can assist in the early diagnosis of cancer by identifying both the presence of cancer and its progression over time [117,118].…”