Application of magnetite ferrofluids for hyperthermia

Hiergeist, R.; Andrä, W.; Buske, N.; Hergt, R.; Hilger, Ingrid; Richter, U.; Kaiser, Werner A.

doi:10.1016/s0304-8853(99)00145-6

Cited by 359 publications

(215 citation statements)

References 5 publications

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“…18),21), 22) In the case of magnetite fine particle, heat generation mechanism changed at ca. 20 nm in particle diameterin from superparamagnetism to ferrimagnetism.…”

Section: Mechanism Of the Heat Generationmentioning

confidence: 99%

Depression of particle growth with calcination at low temperature and their heat generation property in AC magnetic field for the nano-sized magnetic Y3Fe5O12–nSmFeO3 powders prepared by bead-milling

Nishimori

Akiyama

Naohara

et al. 2014

J. Ceram. Soc. Japan

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Nano-sized Y 3 Fe 5 O 12 nSmFeO 3 mixed powder (ca. 20 nm in particle size) was prepared by bead-milling using 0.05 mmº beads for 10 h. For the SmFeO 3 -free sample (n = 0), the heat generation ability in an AC magnetic field (370 kHz, 1.77 kA·m ¹1 ) was 0.34 W·g ¹1 for the bead-milled sample, and it was increased by a calcination at low temperature. The maximum ability of 0.46 W·g ¹1 in an AC magnetic field (370 kHz, 1.77 kA·m ¹1) was obtained for the Y 3 Fe 5 O 12 (n = 0) sample (36.8 nm in particle size) calcined at 700°C. The heat generation mechanism changed from superparamagnetic to ferrimagnetic due to particle growth at 700°C for the n = 0 sample, because the heat generation ability (W·g ¹1) depended on the cube of the magnetic field. A mixed SmFeO 3 phase acted as an impurity for depression of the particle growth for the Y 3 Fe 5 O 12 particles. The heat generation ability was slightly improved by the addition of SmFeO 3 and the maximum value was 0.48 W·g ¹1 in an AC magnetic field (370 kHz, 1.77 kA·m ¹1 ) for n = 0.2 and 0.4 samples. The maximum heat generation ability was decreased for the excessive SmFeO 3 mixed sample (n = 0.6). The calcination temperature for the formation of the ferrimagnetic material was increased by the SmFeO 3 addition due to the depression of particle growth.

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“…18),21), 22) In the case of magnetite fine particle, heat generation mechanism changed at ca. 20 nm in particle diameterin from superparamagnetism to ferrimagnetism.…”

Section: Mechanism Of the Heat Generationmentioning

confidence: 99%

Depression of particle growth with calcination at low temperature and their heat generation property in AC magnetic field for the nano-sized magnetic Y3Fe5O12–nSmFeO3 powders prepared by bead-milling

Nishimori

Akiyama

Naohara

et al. 2014

J. Ceram. Soc. Japan

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“…Due to its unique characteristics, MRFs behave as smart or functional fluids and have been more and more used in a variety of fields such as mechanical engineering, aerospace, precision processing engineering and control engineering [1][2][3]. The most important properties of MRFs are mechanical property and stability performance, but many influence factors would affect the properties such as applied magnetic-field, magnetic particles' properties, added nano-particles, etc.…”

Section: Introductionmentioning

confidence: 99%

Study on the Saturation Properties of Silicone Oil-Based Magnetorheological Fluids in Mechanical Engineering

Wang¹,

Liu²,

Wang³

et al. 2015

TOMEJ

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Abstract:In this paper some saturation properties of silicone oil-based magnetorheological fluids in mechanical engineering were researched and discussed by theoretical analysis and experiments. Firstly, experiment materials and preparation process of silicone oil-based magnetorheological fluids were presented. Secondly, magnetic-field saturation, particles saturation and added nano-particles saturation were elaborated. Finally, the influence of these properties on magnetorheological fluids properties were discussed to provide references for parameter design of magnetorheological fluids preparation and mechanical engineering.

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“…The production of heat can be generated through magnetic hysteretic and relaxation losses (Néel relaxation) as well as through physical rotation (Brownian relaxation) under the influence of an AMF. 4,5 SPION-induced hyperthermia within tumors has been achieved previously but has relied on direct injection of milligram concentrations of iron into superficial tumors, [6][7][8][9][10][11] which limits the approach to only the accessible superficial tumors, such as melanomas. Although functionalization of SPIONs with antibodies, [12][13][14][15] antibody fragments, 16,17 or peptides [18][19][20][21] has been used to enhance the accumulation of SPIONs in tumors, there have been problems with pharmacokinetics, immunogenicity, and toxicity.…”

Section: Introductionmentioning

confidence: 99%

Hyperthermia treatment of tumors by mesenchymal stem cell-delivered superparamagnetic iron oxide nanoparticles

Kalber

Ordidge

Southern³

et al. 2016

IJN

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Magnetic hyperthermia – a potential cancer treatment in which superparamagnetic iron oxide nanoparticles (SPIONs) are made to resonantly respond to an alternating magnetic field (AMF) and thereby produce heat – is of significant current interest. We have previously shown that mesenchymal stem cells (MSCs) can be labeled with SPIONs with no effect on cell proliferation or survival and that within an hour of systemic administration, they migrate to and integrate into tumors in vivo. Here, we report on some longer term (up to 3 weeks) post-integration characteristics of magnetically labeled human MSCs in an immunocompromized mouse model. We initially assessed how the size and coating of SPIONs dictated the loading capacity and cellular heating of MSCs. Ferucarbotran ® was the best of those tested, having the best like-for-like heating capability and being the only one to retain that capability after cell internalization. A mouse model was created by subcutaneous flank injection of a combination of 0.5 million Ferucarbotran-loaded MSCs and 1.0 million OVCAR-3 ovarian tumor cells. After 2 weeks, the tumors reached ~100 µL in volume and then entered a rapid growth phase over the third week to reach ~300 µL. In the control mice that received no AMF treatment, magnetic resonance imaging (MRI) data showed that the labeled MSCs were both incorporated into and retained within the tumors over the entire 3-week period. In the AMF-treated mice, heat increases of ~4°C were observed during the first application, after which MRI indicated a loss of negative contrast, suggesting that the MSCs had died and been cleared from the tumor. This post-AMF removal of cells was confirmed by histological examination and also by a reduced level of subsequent magnetic heating effect. Despite this evidence for an AMF-elicited response in the SPION-loaded MSCs, and in contrast to previous reports on tumor remission in immunocompetent mouse models, in this case, no significant differences were measured regarding the overall tumor size or growth characteristics. We discuss the implications of these results on the clinical delivery of hyperthermia therapy to tumors and on the possibility that a preferred therapeutic route may involve AMF as an adjuvant to an autologous immune response.

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Application of magnetite ferrofluids for hyperthermia

Cited by 359 publications

References 5 publications

Depression of particle growth with calcination at low temperature and their heat generation property in AC magnetic field for the nano-sized magnetic Y<sub>3</sub>Fe<sub>5</sub>O<sub>12</sub>–<i>n</i>SmFeO<sub>3</sub> powders prepared by bead-milling

Depression of particle growth with calcination at low temperature and their heat generation property in AC magnetic field for the nano-sized magnetic Y<sub>3</sub>Fe<sub>5</sub>O<sub>12</sub>–<i>n</i>SmFeO<sub>3</sub> powders prepared by bead-milling

Study on the Saturation Properties of Silicone Oil-Based Magnetorheological Fluids in Mechanical Engineering

Hyperthermia treatment of tumors by mesenchymal stem cell-delivered superparamagnetic iron oxide nanoparticles

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