Application of magnetic nanoparticles in nucleic acid detection

Tang, Cheng; He, Ziyu; Li, Hongmei; Xu, Yuyue; Huang, Hao; Yang, Gaojian; Xiao, Ziqi; Li, Song; Liu, Hongna; Deng, Yan; Zhu, Chen; Hui, Chi Wai; He, Nongyue

doi:10.1186/s12951-020-00613-6

Cited by 186 publications

(81 citation statements)

References 266 publications

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“…To counteract the cationic charge, scientists used serum albumin in preincubated NPs, including shape and size, toxic effects, quantity, and charge density, which should be considered while designing nanomedicine. For example, MRI imaging, cancer diagnostics, precise cell and subcellular treatment, and the detection of genetic mutations NPs have enormous promise, with suitable surface changes in biomedical and therapeutic applications such as nanoparticle surface modification [ 80 ].…”

Section: Synthetic/herbal Nanocrystal Used In Drug Delivery Systemmentioning

confidence: 99%

Molecular Pathogenesis of Colorectal Cancer with an Emphasis on Recent Advances in Biomarkers, as Well as Nanotechnology-Based Diagnostic and Therapeutic Approaches

et al. 2022

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Colorectal cancer (CRC) is a serious disease that affects millions of people throughout the world, despite considerable advances in therapy. The formation of colorectal adenomas and invasive adenocarcinomas is the consequence of a succession of genetic and epigenetic changes in the normal colonic epithelium. Genetic and epigenetic processes associated with the onset, development, and metastasis of sporadic CRC have been studied in depth, resulting in identifying biomarkers that might be used to predict behaviour and prognosis beyond staging and influence therapeutic options. A novel biomarker, or a group of biomarkers, must be discovered in order to build an accurate and clinically useful test that may be used as an alternative to conventional methods for the early detection of CRC and to identify prospective new therapeutic intervention targets. To minimise the mortality burden of colorectal cancer, new screening methods with higher accuracy and nano-based diagnostic precision are needed. Cytotoxic medication has negative side effects and is restricted by medication resistance. One of the most promising cancer treatment techniques is the use of nano-based carrier system as a medication delivery mechanism. To deliver cytotoxic medicines, targeted nanoparticles might take advantage of differently expressed molecules on the surface of cancer cells. The use of different compounds as ligands on the surface of nanoparticles to interact with cancer cells, enabling the efficient delivery of antitumor medicines. Formulations based on nanoparticles might aid in early cancer diagnosis and help to overcome the limitations of traditional treatments, including low water solubility, nonspecific biodistribution, and restricted bioavailability. This article addresses about the molecular pathogenesis of CRC and highlights about biomarkers. It also provides conceptual knowledge of nanotechnology-based diagnostic techniques and therapeutic approaches for malignant colorectal cancer.

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Section: Synthetic/herbal Nanocrystal Used In Drug Delivery Systemmentioning

confidence: 99%

Molecular Pathogenesis of Colorectal Cancer with an Emphasis on Recent Advances in Biomarkers, as Well as Nanotechnology-Based Diagnostic and Therapeutic Approaches

et al. 2022

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“…Magnetic NPs can be easily separated from the media using an external magnetic field during the sample preparation, also called preenrichment [176]. In recent years, magnetic NPs have gained promising attention as solid-phase adsorbents of various biomacromolecules; this method is superior over conventional procedures due to shorter processing times, decreased chemical consumption, and simpler procedure via automation [177]. For this purpose, Zhao and coworkers developed poly(amino ester) with carboxyl group-(PC-) coated magnetic NPs (pcMNPs) for the extraction of SARS-CoV-2 RNA, resulting in the sensitive detection of COVID-19 via RT-PCR [178].…”

Section: Nanotechnology In Rt-pcr-based Detection Ofmentioning

confidence: 99%

Recent Advances on Nanotechnology-Based Strategies for Prevention, Diagnosis, and Treatment of Coronavirus Infections

Alimardani

Abolmaali

Tamaddon

2021

Journal of Nanomaterials

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is exponentially spreading across the world, leading to an outbreak of serious viral pneumonia. Antiviral therapies using chloroquine, hydroxychloroquine, and favipiravir have been approved by several countries to increase the quality of life of SARS-CoV-2-infected patients. Currently, several companies are intensively working on the production of coronavirus (CoV) vaccines, resulting in some specific vaccines that have been approved for CoV infections in humans. Nevertheless, efficient and specific prevention, treatment, and diagnosis are urgently required to combat the biological diversity and rapid mutation in CoV infections. Recently, significant attention has devoted to nanoformulation or nanoparticles (NPs) due to their specific features like high surface-to-volume ratio, drug encapsulation abilities, and specific optical properties to remove the complications of applied conventional therapeutic and diagnosis options. In this regard, NPs are increasingly used as new anti-CoV agents, vaccine carriers or adjuvants, and nanoscale biorecognition elements. The present review article provides a comprehensive discussion on the recent updates regarding the prevention, diagnosis, and treatment of different CoV infections with an emphasis on the application of NPs in vaccination, treatment, and diagnosis of CoV infections.

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“…Biosensors based on concurrent DNA-DNA hybridization for the simultaneous detection of various bacterial strains of the same species have unparallel importance in selecting accurate drug therapy [1,2]. DNA biosensors have become the leading diagnostic technology for detecting and discriminating genotypes of various bacterial and viral strains [3,4]. The sensitivity of the DNA biosensors depends on two factors: (i) the signal to background ratio (SBR) and (ii) the specific to non-specific hybridization ratio, which is also called the single nucleotide polymorphism (SNP) discrimination ratio.…”

Section: Introductionmentioning

confidence: 99%

A Novel Method That Allows SNP Discrimination with 160:1 Ratio for Biosensors Based on DNA-DNA Hybridization

Nimse

Song²,

Warkad³

et al. 2021

Biosensors

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Highly sensitive (high SBR) and highly specific (high SNP discrimination ratio) DNA hybridization is essential for a biosensor with clinical application. Herein, we propose a method that allows detecting multiple pathogens on a single platform with the SNP discrimination ratios over 160:1 in the dynamic range of 101 to 104 copies per test. The newly developed SWAT method allows achieving highly sensitive and highly specific DNA hybridizations. The detection and discrimination of the MTB and NTM strain in the clinical samples with the SBR and SNP discrimination ratios higher than 160:1 indicate the high clinical applicability of the SWAT.

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Application of magnetic nanoparticles in nucleic acid detection

Cited by 186 publications

References 266 publications

Molecular Pathogenesis of Colorectal Cancer with an Emphasis on Recent Advances in Biomarkers, as Well as Nanotechnology-Based Diagnostic and Therapeutic Approaches

Molecular Pathogenesis of Colorectal Cancer with an Emphasis on Recent Advances in Biomarkers, as Well as Nanotechnology-Based Diagnostic and Therapeutic Approaches

Recent Advances on Nanotechnology-Based Strategies for Prevention, Diagnosis, and Treatment of Coronavirus Infections

A Novel Method That Allows SNP Discrimination with 160:1 Ratio for Biosensors Based on DNA-DNA Hybridization

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