Application of magnetic nanoparticles in biomedicine

Pershina, Alexandra G.; Sazonov, A. E.; Milto, I. V.

doi:10.20538/1682-0363-2008-2-70-78

Cited by 24 publications

(1 citation statement)

References 75 publications

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“…For example, Au nanoparticles may be functionalized with high-density lipoproteins [ 21 ] or bisphosphonates [ 22 ], while HfO 2 nanoparticles can be modified with nitrilotriacetic acid to improve their affinity for calcium, which has made it possible to visualize microcracks in bones [ 4 ]. Nanoparticles also have some disadvantages, i.e., their tendency to aggregate, as well as their insolubility in water [ 23 ]. However, this can be prevented by modifying their surfaces with hydrophilic polymers, for example, with polyethylene glycol [ 24 ], or by using an inorganic matrix based on SiO 2 [ 25 , 26 , 27 ] or carbon nanotubes [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

New Composite Contrast Agents Based on Ln and Graphene Matrix for Multi-Energy Computed Tomography

et al. 2022

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The subject of the current research study is aimed at the development of novel types of contrast agents (CAs) for multi-energy computed tomography (CT) based on Ln–graphene composites, which include Ln (Ln = La, Nd, and Gd) nanoparticles with a size of 2–3 nm, acting as key contrasting elements, and graphene nanoflakes (GNFs) acting as the matrix. The synthesis and surface modifications of the GNFs and the properties of the new CAs are presented herein. The samples have had their characteristics determined using X-ray photoelectron spectroscopy, X-Ray diffraction, transmission electron microscopy, thermogravimetric analysis, and Raman spectroscopy. Multi-energy CT images of the La-, Nd-, and Gd-based CAs demonstrating their visualization and discriminative properties, as well as the possibility of a quantitative analysis, are presented.

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