Application of magnetic arrangement of microbeads for CMOS biosensor array sensitivity

Ushijima, Eizo; Fujimoto, Satoshi; Niitsu, Kiichi; Nakazato, Kazuhiko

doi:10.1109/biocas.2017.8325048

Cited by 2 publications

(3 citation statements)

References 3 publications

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Section: Resultsmentioning

confidence: 99%

“…The third was increasing the magnetic susceptibility difference between a substance and the surrounding medium . In addition, utilizing magnetophoresis, , which is the controlled manipulation of microparticles in space and time through the insertion of the flow path mechanism, it is possible to reduce the size variation of microparticles, disperse the microparticles with low concentrations in the surrounding medium, and remove excess microparticles distributed in any area other than the holes. It is expected that potential application fields will be expanded by increasing the arrangement accuracy.…”

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Arranging Diamagnetic Particles in a Modulated Magnetic Field Originating in Microelectromechanical Systems Compatible with an Integrated Circuit upon Halbach Array Magnet

Ushijima

Fujimoto²,

Nakazato

2020

ACS Omega

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In this study, we attempted to expand the applicability of the mechanism for arranging diamagnetic particles in a modulated magnetic field. A Halbach array magnet was prototyped as a portable device for generating a high magnetic field. Despite the magnet being palm-size with dimensions of 50 × 50 × 20 mm, the magnetic field is 1.31 T at 1 mm from the surface. Additionally, an Si substrate on which an Fe thin film is formed and patterned to be compatible with the integrated circuit (IC)—utilizing the microelectromechanical systems process technology—is prototyped as a tool to generate a modulated magnetic field. Regarding the deposition condition of the Fe thin film, holes with diameters of 30 μm are arranged in an array at intervals of 60 μm, and the thickness is approximately 0.5 μm. Finally, a particle magnetic-adsorption experiment was conducted using the prototypes. The diamagnetic particles (diameter: 25 μm) dispersed in the paramagnetic surrounding medium were observed to be arranged in the hole portions. This result indicates that the microparticles are absorbed in their arbitrary positions by the modulated magnetic field. In the end, we succeeded in achieving the portability and implementation on IC for the particle arrangement magnetic mechanism.

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Section: Resultsmentioning

confidence: 99%