Application of Low Reactive-Level Laser Therapy (Lllt) in the Functional Training of Cerebral Palsy Patients

Asagai, Yoshimi; Kanai, Hiroshi; Miura, Yukio; Ohshiro, Toshio

doi:10.5978/islsm.94-or-14

Cited by 20 publications

(10 citation statements)

References 2 publications

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“…The points of laser irradiation were those used to alleviate the muscle spasticity of cerebral palsy patients; the points were at the neck, 4 points along the thoracic and lumbar paraspinal musculature, the root of the tibial nerve, and over the gôkoku and inpô acupuncture points for a total of 16 points for both sides of the body. Each point was irradiated with the laser for 1 minute to give a total irradiation time of 16 minutes per session 7,8) . Urinalysis and blood sample analysis were performed prior to the laser irradiation and at 1, 2, 4, 10 and 24 months after laser irradiation and the following were examined: Type 1 collagen cross-linked N-telopeptide (NTx)/crea, Deoxy-Pyridinoline (DPd), DPd/crea, serum NTx, and urine NTx were measured as bone resorption markers while bone specific alkaline phosphatase (B-ALP), measured with an enzyme immuno-assay, and osteocalcin were used as markers for bone formation.…”

Section: Methodsmentioning

confidence: 99%

The effect of LLLT on bone metabolism in children with severe cerebral palsy (a secondary publication)

Asagai¹

2014

LASER THERAPY

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These results suggest that LLLT has a positive influence on bone metabolism in that it temporarily increases bone formation and suppresses bone resorption while also tending to improve secondary hyperparathyroidism caused by VitD deficiency. Enhanced bone resorption in the case with high NTx levels was noteworthy, together with marked changes in the case with high PTH levels due to VitD deficiency. These positive influences on bone metabolism merit attention as potential new indications of LLLT.

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Section: Methodsmentioning

confidence: 99%

The effect of LLLT on bone metabolism in children with severe cerebral palsy (a secondary publication)

Asagai¹

2014

LASER THERAPY

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“…Earlier studies suggested that infrared (IR) low level laser therapy (LLLT) can affect the activity of nervous tissues [1][2][3][4], improving recovery from nerve injuries in experimental rat models [5,6] and in clinical investigations [7][8][9]. However, the effect of this low-intensity laser irradiation on nerve function, growth, and repair is a contentious area of research because the studies are often poorly controlled and the results not fully reported [3,4].…”

Section: Introductionmentioning

confidence: 99%

Neurotransmitter release changes induced by low power 830 nm diode laser irradiation on the neuromuscular junctions of the mouse

et al. 2004

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The irradiated (12 J/cm2) muscles showed a significant reduction in quantal content (P = 0.01) and EPP amplitude (P = 0.04), but the latency, spontaneous transmitter release (MEPPs) and paired pulse facilitation did not change. No alterations were observed in NMJ irradiated with 4 J/cm2. We conclude that 830 nm diode laser irradiation (at a dose of 12 J/cm2) can affect the evoked neurotransmitter release in the mouse motor endplates.

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“…(1,2) One of the mechanisms of the efficacy of LLLT is thought to be through improvement of tissue blood perfusion, and we have reported thermographic changes showing an increase in skin temperature following LLLT in cerebral palsy cases. (3,4) Currently there are many reported methods in the LLLT field concerning parameters, such as the point of laser irradiation, output power, or power desnity, and irradiation time or energy density/dose.…”

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confidence: 92%

Assessment of Changes in Carotid Blood Flow Following LLLT of the Neck

Asagai

Sujaritpong²,

Tranvan³

et al. 2007

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We have reported previously on the efficacy of LLLT for the reduction of tonic muscle spasms in cerebral palsy patients and for the prevention of femoral head necrosis in pediatric patients. (1,2) One of the mechanisms of the efficacy of LLLT is thought to be through improvement of tissue blood perfusion, and we have reported thermographic changes showing an increase in skin temperature following LLLT in cerebral palsy cases. (3,4) Currently there are many reported methods in the LLLT field concerning parameters, such as the point of laser irradiation, output power, or power desnity, and irradiation time or energy density/dose. In order to objectively assess the difference in response of in vivo blood flow changes according to different laser parameters, we used non-invasive Doppler ultrasound color flow imaging and observed changes in the blood flow of the common carotid arteries following irradiation with different LLLT parameters, at the same time using the same diagnostic ultrasound system to measure diameter and cross-sectional area of the vessels. Subjects and MethodsTwelve spastic cerebral palsy patients, 7 males and 5 females, were enrolled in this study. The ages of the patients ranged from 15 to 18 years old with an average age of 16. The diagnostic ultrasound device used was the Prosound SSD-3500, (Aloka Co., Ltd., Tokyo, Japan) with a 29 mm wide superficial electronic linear probe attached (Fig. 1). Patients were placed in the supine position and long axis images of the bilateral common carotid arteries were obtained where the image of the vessel walls became parallel. Images of the systolic period were recorded and used for measurements. (Fig. 2) The laser used was a gallium aluminum arsenide (GaAlAs) diode laser, JQ305, (Minato Medical Science, Co., Ltd., Japan) giving output powers in continuous 127 There are several reports on improvement of blood flow following LLLT, and reports on actual vessel dilatation and blood flow enhancement has been observed in animal models. However there are no reports on changes in blood flow observed in human subjects using a non-invasive method for any duration of time. In this study, we used non-invasive Doppler color flow imaging to observe changes in the blood flow of the common carotid artery following laser irradiation to the lateral neck region. Laser output-and dose-dependent differences in the blood flow were observed, but there was also an increase in the diameter and cross-sectional area of vessels. Increased blood flow was noted in the common carotid artery of both the irradiated and unirradiated side, which lasted for over 1 hour after laser irradiation. The maximum increase in the crosssectional area, vessel diameter and the blood flow on the irradiated side were 69%, 31% and 63% respectively. On the unirradiated side the maximum increase of the cross-sectional area, vessel diameter and blood flow were 52%, 21% and 71% respectively. There were no changes observed in the maximum, minimum or average blood flow velocity of either the irradiated or unir...

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Application of Low Reactive-Level Laser Therapy (Lllt) in the Functional Training of Cerebral Palsy Patients

Cited by 20 publications

References 2 publications

The effect of LLLT on bone metabolism in children with severe cerebral palsy (a secondary publication)

The effect of LLLT on bone metabolism in children with severe cerebral palsy (a secondary publication)

Neurotransmitter release changes induced by low power 830 nm diode laser irradiation on the neuromuscular junctions of the mouse

Assessment of Changes in Carotid Blood Flow Following LLLT of the Neck

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