Application of low dose radiation and low concentration contrast media in enhanced CT scans in children with congenital heart disease

Liu, Zhimin; Song, Lei; Yu, Tao; Gao, Jun; Zhang, Zuo‐Feng; Jiang, Ling; Liu, Yong; Peng, Yun

doi:10.1111/ijcp.12857

Cited by 7 publications

(6 citation statements)

References 11 publications

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“…The patients in this group were treated with Philips' latest HP Sonos-5500 color Doppler ultrasound system, using S3, S4, and 3V2c phased array ultrasound probes with an ultrasound frequency of 2.5-3.5 KHz. 16 The patient was placed in the usual supine or left position, then we used the left ventricular long axis section, apical four-cavity heart, five cavity heart to finish scanning. 17,18 The internal and external structures of the heart were observed in two dimensions, and then the internal and external flow of the heart was displayed in the color doppler energy (CDE).…”

Section: Cardiac Ultrasonographymentioning

confidence: 99%

Comparison of echocardiography and 64‐slice spiral computed tomography in the diagnosis of congenital heart disease in children

Mei

Nie

Yang

et al. 2018

J of Cellular Biochemistry

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The diagnosis of congenital heart disease in children has been an issue in the medical community. Timely diagnosis and treatment can provide a greater guarantee for children's healthy growth. In recent years, there have been more and more studies on the diagnosis of congenital heart disease in children. This paper compares the advantages and disadvantages of echocardiography and 64-slice spiral computed tomography (CT) in the diagnosis of congenital heart disease in children. In clinical trials, we also tested 64 patients with spiral computed tomography (SCT) and transthoracic echocardiography (TTE) detection of patients and then confirmed the accuracy of the diagnosis by the surgical methods. The two methods of detection, the rate of missed diagnosis, and the rate of misdiagnosis were counted. Through the test results and pathological diagnosis results, the diagnostic accuracy of the two methods were all above 90%, each with its own advantages and disadvantages. The sensitivity of echocardiographic in detecting intracardiac structure abnormalities was relatively high, but when the diagnosis of extracardiac structural abnormalities less than 64-slice spiral CT method, misdiagnosis of TTE was mainly due to extracardiac vascular malformations. Therefore, it is recommended to combine the two methods to improve the diagnosis of congenital heart disease in children.

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Section: Cardiac Ultrasonographymentioning

confidence: 99%

Comparison of echocardiography and 64‐slice spiral computed tomography in the diagnosis of congenital heart disease in children

Mei

Nie

Yang

et al. 2018

J of Cellular Biochemistry

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“…This suggests that the CdTe detector offered a better imaging contrast, which could be pivotal in contrast agent discrimination and could potentially allow lower concentrations of contrast agents to be used. Lower concentration contrast agents reduce the risk of contrast induced nephropathy and nephrogenic systemic fibrosis which are rare conditions associated with contrast imaging agents [15]. Additionally, SAIR seemed to offer better geometric accuracy for the 1% vials than K-edge subtraction for the CdTe data.…”

Section: Discussionmentioning

confidence: 99%

“…The benefits of two energy channels in material decomposition CT are beginning to become clear as dual-energy CT testing grows, however the increased benefits that could be obtained from multi-energy CT are only beginning to be seen and are perhaps under-studied [14]. Multi-contrast imaging has the potential to reduce the need for multiple CT scans by allowing for various disease markers to be checked in one scan, ultimately saving time, reducing patients' total radiation dose [15], and offering more value per scan.…”

Section: Jinst 17 P01004mentioning

confidence: 99%

Multi-contrast CT imaging using a high energy resolution CdTe detector and a CZT photon-counting detector

et al. 2022

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Computed tomography (CT) imaging with high energy resolution detectors shows great promise in material decomposition and multi-contrast imaging. Multi-contrast imaging was studied by imaging a phantom with iodine (I), gadolinium (Gd), and gold (Au) solutions, and mixtures of the three using a cadmium telluride (CdTe) spectrometer with an energy resolution of 1% as well as with a cadmium zinc telluride (CZT) detector with an energy resolution of 13%. The phantom was imaged at 120 kVp and 1.1 mA with 7 mm of aluminum filtration. For the CdTe data collection, the phantom was imaged using a 0.2 mm diameter x-ray beam with 96 ten-second data acquisitions across the phantom at 45 rotation angles. For the CZT detector, we had 720 projections using a cone beam, and the six detector energy thresholds were set to 23, 33, 50, 64, 81, and 120 keV so that three thresholds corresponded to the K-edges of the contrast agents. Contrast agent isolation methods were then examined. K-edge subtraction and novel spectrometric algebraic image reconstruction (SAIR) were used for the CdTe data. K-edge subtraction alone was used for the CZT data. Linearity plots produced similar R 2 values and slopes for all three reconstruction methods. Comparing CdTe methods, SAIR offered less noise than CdTe K-edge subtraction and better geometric accuracy at low contrast concentrations. CdTe contrast agent images of I, Gd, and Au offered less noise and greater contrast than the CZT images, highlighting the benefits of high energy resolution CdTe detectors for possible use in pre-clinical or clinical CT imaging.

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“…Radiological imaging is an extremely valuable diagnostic tool used in pediatrics. Pediatric radiographic chest examinations are commonly used as an accompaniment in congenital heart disease (CHD) related surgical correction procedures, potentially exposing the patients to high levels of radiation [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…Due to the satisfactory results and low costs, the chest radiography scan is accepted worldwide as an accurate diagnostic method [ 2 ]. However, since the developing cells of young patients are particularly radiosensitive, pediatric radiographic examinations need to be performed with greater attention and precision.…”

Section: Introductionmentioning

confidence: 99%

Choice of tube extremity for emission of the lowest radiation dose in pediatric patients

Rodrigues

Medeiros

Rodrigues

et al. 2018

IJC Heart & Vasculature

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AimsTo compare the dosage of radiation the thyroid and gonad glands receive in pediatric patients undergoing chest X-rays, in distinct positions, towards the goal of developing of an X-ray tube positioning protocol.MethodsA randomized controlled clinical trial was carried out in the Pediatric Intensive Care Unit (PICU) at the Institute of Cardiology/University Foundation of Cardiology of Rio Grande do Sul, Brazil from June 2014 to September 2016. Patients were divided into two groups. One group was positioned with the thyroid gland facing the anode end of an X-ray tube, and in the other group the thyroid gland faced the cathode end. Radiographs were evaluated by five observers, following criteria recommended by the Commission of the European Communities (CEC).ResultsForty-eight pediatric patients, with a mean age of 2.0 ± 1.3 years, participated in this study. Based on the evaluation of 48 images, it was determined that the thyroid and gonad glands facing the cathode were exposed to 13.3 ± 3.1 μGy and 13.5 ± 4.1 μGy of radiation, respectively (p = 0.008). Additionally, the thyroid and gonad glands facing the anode were exposed to 11.7 ± 3.1 μGy and 12.7 ± 3.1 μGy of radiation, respectively (p = 0.007). The mean input dose in the center of the chest was 20.8 ± 9.6 μGy in both positions.DiscussionThe proximity of the thyroid gland to the cathode end of the X-ray tube appears to be related to the dosage of ionizing radiation. Adverse effects associated with exposure to ionizing radiation could be minimized by positioning the thyroid gland to the anodic end of the X-ray tube.ConclusionPatients should be placed facing the anode end of the X-ray tube when taking thoracic X-rays, in order to reduce radiation exposure to the thyroid and gonad glands.ClinicalTrials.gov Identifier: NCT02925936.

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Application of low dose radiation and low concentration contrast media in enhanced CT scans in children with congenital heart disease

Abstract: Enhanced CT scan images with low dose radiation and low concentration contrast media can meet the diagnostic requirements for examining children with congenital heart disease while reducing the potential risk of radiation damage and contrast-induced nephropathy.

Cited by 7 publications

References 11 publications

Comparison of echocardiography and 64‐slice spiral computed tomography in the diagnosis of congenital heart disease in children

Comparison of echocardiography and 64‐slice spiral computed tomography in the diagnosis of congenital heart disease in children

Multi-contrast CT imaging using a high energy resolution CdTe detector and a CZT photon-counting detector

Choice of tube extremity for emission of the lowest radiation dose in pediatric patients

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