“…4 A detailed literature survey for AB revealed that several analytical methods are reported for the determination of amlodipine with atorvastatine by HPLC, 5 amlodipine with atenolol by HPLC 6 and by HPTLC, 7 amlodipine with metaprolol by HPLC 8 and amlodipine alone by HPLC, 9 HPTLC, 10 LC-MS 11 and GC. 12 Similarly, a literature survey for BH revealed that few techniques have been reported for the determination of BH alone by HPLC, 13 HPTLC, 14 CE, 15 GC-MS, 16 LC-MS, 17 spectrophotometric detection 18 and by voltammetrically 19 from pharmaceutical dosage form. Only two methods have been reported for the simultaneous determination of AB and BH; one describes the RP-HPLC procedure 20 and the other describes HPTLC procedure, 21 but both these methods are time-consuming.…”